Application of drug delivery systems for the controlled delivery of growth factors to treat nervous system injury

The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger.

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Nanomedicine Applications in Treatment of Primary Central Nervous System Lymphoma: Current State of the Art

Journal of Biomedical Nanotechnology ◽

10.1166/jbn.2021.3133 ◽

2021 ◽

Vol 17 (8) ◽

pp. 1459-1485

Author(s):

Mengyao Wang ◽

Ying Qu ◽

Danrong Hu ◽

Ting Niu ◽

Zhiyong Qian

Keyword(s):

Drug Delivery ◽

Central Nervous System ◽

Nervous System ◽

Drug Delivery Systems ◽

Central Nervous System Lymphoma ◽

Delivery Systems ◽

Brain Diseases ◽

Current Status ◽

Great Promise ◽

Antitumor Effects

Primary central nervous system lymphoma (PCNSL) is a rare but highly aggressive subtype of extra nodal non-Hodgkin lymphoma (NHL), which is confined in the central nervous system (CNS). Despite recent advancements in treatment options, the overall prognosis of PCNSL remains poor. Among many unfavorable factors affecting efficacy, inadequate drug delivery into the CNS is still the thorniest challenge. Blood-brain barrier (BBB) constitutes a significant impediment, restricting entry of most therapeutics to the brain. Nanotechnology has offered great promise for brain diseases, as various nano-based drug delivery systems (NDDSs) have been developed for delivery of theranostic agents in to the CNS. These drug delivery systems possess significant advantages, including good feasibility, reliable safety profile, excellent BBB penetration and potent antitumor effects. As for treatment of PCNSL, numerous well-developed BBB-crossing nano-based strategies can be applied with proper modifications and improvements. Some exquisitely designed NDDSs specific for PCNSL have shown great potential. In this review, we provide a summary on current status of diagnosis and treatment of PCNSL, followed by an overview of BBB-crossing strategies applied in management of PCNSL, both novel and wellestablished. Finally, challenges and future perspectives in this field are also discussed.

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Development and in vitro evaluation of chitosan-based transdermal drug delivery systems for the controlled delivery of propranolol hydrochloride

Biomaterials ◽

10.1016/0142-9612(95)98278-m ◽

1995 ◽

Vol 16 (2) ◽

pp. 145-148 ◽

Cited By ~ 88

Author(s):

D. Thacharodi ◽

K.Panduranga Rao

Keyword(s):

Drug Delivery ◽

Transdermal Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Controlled Delivery ◽

Propranolol Hydrochloride ◽

In Vitro Evaluation ◽

Transdermal Drug Delivery Systems

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Nanotechnology-based drug-delivery systems releasing growth factors to the CNS

Nanobiomaterials in Drug Delivery ◽

10.1016/b978-0-323-42866-8.00011-3 ◽

2016 ◽

pp. 371-402

Author(s):

Oihane Gartziandia ◽

Enara Herran ◽

Jose Luis Pedraz ◽

Manoli Igartua ◽

Rosa Maria Hernandez

Keyword(s):

Drug Delivery ◽

Growth Factors ◽

Drug Delivery Systems ◽

Delivery Systems

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Pharmacosomes: An approach to improve biopharmaceutical properties of drugs basic considerations in development

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00779 ◽

2021 ◽

pp. 4485-4490

Author(s):

Popat Kumbhar ◽

Tejaswini Shinde ◽

Tejaswini Jadhav ◽

Tejas Gavade ◽

Rushikesh Sorate ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Drug Stability ◽

Entrapment Efficiency ◽

Delivery Systems ◽

Controlled Delivery ◽

State Measurement ◽

High Entrapment Efficiency ◽

Biopharmaceutical Properties

Vesicular drug delivery systems including niososmes, liposomes, pharmacosomes, transferosomes, electrosomes, ethosomes, etc have been widely accepted for controlled delivery of the drug. Amongst, all these drug delivery systems pharmacosomes are gaining more attention of the researchers due to several benefits such as high entrapment efficiency, improved biopharmaceutical properties, and pharmacokinetic performance, no leakage or loss of drug, stability, etc. Pharmacosomes are amphiphilic phospholipid complexes of drugs having active hydrogen that bind to phospholipids and self-assembled into vesicles in an aqueous medium. Both hydrophilic and lipophilic drugs have been formulated into pharmacosomes that caused improved solubility and permeability of drugs. Pharmacosomes are prepared by using various techniques such as hand shaking method, ether injection, solvent evaporation method, supercritical fluid approach, etc and are characterized for prodrug confirmation, surface morphology, crystal state measurement, in vitro drug release, and stability, etc. Despite wide research and highly encouraging results in the preclinical studies, translation of these nanomedicines from laboratory to market has been very limited. The main aim of this review is to describe comprehensively the potential of pharmacosomes as a vesicular drug delivery system focusing mainly on their conventional and advanced methods of preparation, different characterization techniques, and their applications in the delivery of different types of drugs with improved biopharmaceutical properties and pharmacokinetic performance.

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Novel Central Nervous System Drug Delivery Systems

Chemical Biology & Drug Design ◽

10.1111/cbdd.12268 ◽

2014 ◽

Vol 83 (5) ◽

pp. 507-520 ◽

Cited By ~ 52

Author(s):

Jocelyn Stockwell ◽

Nabiha Abdi ◽

Xiaofan Lu ◽

Oshin Maheshwari ◽

Changiz Taghibiglou

Keyword(s):

Drug Delivery ◽

Central Nervous System ◽

Nervous System ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Central Nervous System Drug

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Evaluation of pilocarpine-loaded albumin particles as drug delivery systems for controlled delivery in the eye I. In vitro and in vivo characterisation

Journal of Controlled Release ◽

10.1016/0168-3659(94)90225-9 ◽

1994 ◽

Vol 32 (1) ◽

pp. 57-70 ◽

Cited By ~ 34

Author(s):

Annette Katharina Zimmer ◽

Horst Zerbe ◽

Jörg Kreuter

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Controlled Delivery

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Controlled Drug Delivery Systems

Drug Delivery ◽

10.1093/oso/9780195085891.003.0015 ◽

2001 ◽

Author(s):

W. Mark Saltzman

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Sustained Release ◽

Drug Delivery Systems ◽

Active Agent ◽

Polymeric Materials ◽

Spatial Localization ◽

Delivery Systems ◽

Controlled Delivery ◽

Drug Modification

In most forms of drug delivery, spatial localization and duration of drug concentration are constrained by organ physiology and metabolism. For example, drugs administered orally will distribute to tissues based on the principles of diffusion, permeation, and flow presented in Part II of this book. If the duration of therapy provided by a single administration is insufficient, the drug must be readministered. Localization of drug can be controlled by injection, but only within limited spatial constraints, and effectiveness after an injection is usually short-lived. Controlled-delivery systems offer an alternative approach to regulating both the duration and spatial localization of therapeutic agents. In controlled delivery, the active agent is combined with other (usually synthetic) components to produce a delivery system. Unlike drug modification, which results in new agents that are single molecules, or assemblies of a limited number of molecules, drug delivery systems are usually macroscopic. Like drug modification, controlled-delivery systems frequently involve combinations of active agents with inert polymeric materials. In this text, controlled-delivery systems are distinguished from “sustained-release” drug formulations. Sustained release is often achieved by mixing an active agent with excipients or binders that alter the agent’s rate of dissolution in the intestinal tract or adsorption from a local injection site. The distinction between sustained release (often achieved by drug formulation) and controlled delivery or controlled release is somewhat arbitrary. In our definition, controlled delivery systems must (1) include a component that can be engineered to regulate an essential characteristic (e.g., duration of release, rate of release, or targeting) and (2) have a duration of action longer than a day. Many polymeric materials are available for the development of drug delivery systems (see Appendix A). Non-degradable, hydrophobic polymers have been used the most extensively. Reservoir drug delivery devices, in which a liquid reservoir of drug is enclosed in a silicone elastomer tube, were first demonstrated to provide controlled release of small molecules several decades ago [1]. This discovery eventually led to clinically useful devices, including the Norplant® (Wyeth-Ayerst Laboratories) contraceptive delivery system, which provides reliable delivery of levonorgestrel for 5 years following subcutaneous implantation.

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