Iron oxide nanoparticles aggravate hepatic steatosis and liver injury in nonalcoholic fatty liver disease through BMP-SMAD-mediated hepatic iron overload

2021 ◽  
pp. 1-18
Author(s):  
Meilin Zhu ◽  
Hanqing Chen ◽  
Shuang Zhou ◽  
Lingna Zheng ◽  
Xue Li ◽  
...  
Keyword(s):  
Liver Disease ◽  
Iron Oxide ◽  
Liver Injury ◽  
Iron Overload ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Oxide Nanoparticles ◽  
Hepatic Iron ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Iron Overload

scholarly journals The A736V TMPRSS6 Polymorphism Influences Hepatic Iron Overload in Nonalcoholic Fatty Liver Disease

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e48804 ◽  
Author(s):  
Luca Valenti ◽  
Raffaela Rametta ◽  
Paola Dongiovanni ◽  
Benedetta M. Motta ◽  
Elena Canavesi ◽  
...  
Keyword(s):  
Liver Disease ◽  
Iron Overload ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Hepatic Iron ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Iron Overload

Hepatic STAMP2 mediates recombinant FGF21‐induced improvement of hepatic iron overload in nonalcoholic fatty liver disease

2020 ◽  
Vol 34 (9) ◽  
pp. 12354-12366
Author(s):  
Hye Young Kim ◽  
Woo Young Kwon ◽  
Joon Beom Park ◽  
Mi Hwa Lee ◽  
Yoo Jin Oh ◽  
...  
Keyword(s):  
Liver Disease ◽  
Iron Overload ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Hepatic Iron ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Iron Overload

Hepatic iron overload analysis bymagnetic resonance imaging in a non-alcoholic fatty liver disease population

2017 ◽  
Vol 66 (1) ◽  
pp. S244-S245
Author(s):  
H.M.L. Filho ◽  
P. Fabrega ◽  
W. Chua-anusorn ◽  
C.P. Oliveira ◽  
F.J. Carrilho ◽  
...  
Keyword(s):  
Liver Disease ◽  
Iron Overload ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Hepatic Iron ◽  
Resonance Imaging ◽  
Alcoholic Fatty Liver ◽  
Hepatic Iron Overload ◽  
Alcoholic Fatty Liver Disease

scholarly journals Prevalence of Fatty Liver Disease and Hepatic Iron Overload in a Northeastern German Population by Using Quantitative MR Imaging

Radiology ◽  
2017 ◽  
Vol 284 (3) ◽  
pp. 706-716 ◽  
Author(s):  
Jens-Peter Kühn ◽  
Peter Meffert ◽  
Christian Heske ◽  
Marie-Luise Kromrey ◽  
Carsten O. Schmidt ◽  
...  
Keyword(s):  
Liver Disease ◽  
Mr Imaging ◽  
Iron Overload ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
German Population ◽  
Hepatic Iron ◽  
Quantitative Mr Imaging ◽  
Quantitative Mr ◽  
Hepatic Iron Overload

The Relationship of Serum Hemojuvelin and Hepcidin Levels with Iron Overload in Nonalcoholic Fatty Liver Disease

2015 ◽  
Vol 24 (3) ◽  
pp. 293-300 ◽  
Author(s):  
Salih Boga ◽  
Huseyin Alkim ◽  
Canan Alkim ◽  
Ali Riza Koksal ◽  
Mehmet Bayram ◽  
...  
Keyword(s):  
Liver Disease ◽  
Iron Overload ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Clinical Characteristics ◽  
Serum Levels ◽  
Fibrosis Stage ◽  
Enzyme Linked Immunosorbent Assay ◽  
Nonalcoholic Fatty Liver

Background & Aims: Mild iron overload is frequently reported in patients with nonalcoholic fatty liver disease (NAFLD). Hepcidin is the master iron-regulatory peptide and hemojuvelin (HJV) is the key regulator of iron-dependent secretion of hepcidin. The aims of this study were to evaluate serum HJV and hepcidin levels in patients with biopsy-proven NAFLD with and without hepatic iron overload, and to identify potential associations of HJV and hepcidin with the clinical characteristics of the patients enrolled. Methods: Serum levels of HJV and hepcidin were measured in 66 NAFLD patients with (n=12) and without (n=54) iron overload, and controls (n=35) by enzyme-linked immunosorbent assay. Hemojuvelin and hepcidin levels were assessed in relation to clinical characteristics and liver histologic evaluation of the participants. Results: Significantly lower serum HJV (281.1 [239.2-353.6] vs. 584.8 [440.3-661] ng/ml, p<0.001) and similar serum hepcidin levels (60.5±31.1 vs. 55.8±11.9 ng/ml, p=0.285) were found in NAFLD patients when compared to controls. İron-overloaded NAFLD patients had significantly lower HJV (249.9 [187.6-296.3] vs. 292.9 [243-435] ng/ml, p=0.032) and significantly higher hepcidin (78.4±35.5 vs. 56.5±28.9ng/ml, p=0.027) levels than NAFLD patients without iron overload. Fibrosis stage was significantly higher in iron overloaded NAFLD group (p<0.001). Ferritin levels correlated significantly both with HOMA-IR (r=0.368, p=0.002) and fibrosis stage (r=0.571, p<0.001). Conclusions: Our findings suggest that HJV levels are low in NAFLD and even lower in iron overloaded NAFLD, while hepcidin levels are higher in NAFLD with iron overload. The gradually decreased HJV and increased hepcidin concentrations in our patients most likely reflect the physiological response to iron accumulation in the liver.

358 - Statin Use and Liver Injury in Nonalcoholic Fatty Liver Disease: Results of a Paired Clinical and Gene Expression Profile Analysis

2018 ◽  
Vol 154 (6) ◽  
pp. S-1085-S-1086
Author(s):  
Andrew Bae ◽  
Ricardo Henao ◽  
Ayako Suzuki ◽  
Cynthia A. Moylan ◽  
Cynthia D. Guy ◽  
...  
Keyword(s):  
Gene Expression ◽  
Liver Disease ◽  
Liver Injury ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Profile Analysis ◽  
Nonalcoholic Fatty Liver ◽  
Expression Profile Analysis ◽  
Statin Use

The traditional Japanese formula keishibukuryogan reduces liver injury and inflammation in patients with nonalcoholic fatty liver disease

2010 ◽  
Vol 1190 (1) ◽  
pp. 151-158 ◽  
Author(s):  
Makoto Fujimoto ◽  
Koichi Tsuneyama ◽  
Hideki Kinoshita ◽  
Hirozo Goto ◽  
Yasuo Takano ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Injury ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver

T1009 Severity of Liver Injury and Cardiovascular Risk in Children with Nonalcoholic Fatty Liver Disease

2009 ◽  
Vol 136 (5) ◽  
pp. A-845
Author(s):  
Valerio Nobili ◽  
Naim Alkhouri ◽  
Anna Alisi ◽  
Melania Manco ◽  
Andrea Bartuli ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Liver Disease ◽  
Liver Injury ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver
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