scholarly journals Intrauterine transfusion and non-invasive treatment options for hemolytic disease of the fetus and newborn – review on current management and outcome

2017 ◽  
Vol 10 (4) ◽  
pp. 337-344 ◽  
Author(s):  
Carolien Zwiers ◽  
Inge van Kamp ◽  
Dick Oepkes ◽  
Enrico Lopriore
Keyword(s):  
Treatment Options ◽  
Hemolytic Disease ◽  
Invasive Treatment ◽  
Current Management ◽  
Non Invasive ◽  
Intrauterine Transfusion

scholarly journals Updated Costs of Uterine Fibroid Treatments Including Focused Ultrasound Surgery

2018 ◽  
Author(s):  
Bijan J. Borah ◽  
Elizabeth A. Stewart
Keyword(s):  
Magnetic Resonance ◽  
Focused Ultrasound ◽  
Treatment Options ◽  
Uterine Fibroids ◽  
Reproductive Age ◽  
Invasive Treatment ◽  
Ultrasound Surgery ◽  
Non Invasive ◽  
Focused Ultrasound Surgery ◽  
Reproductive Age Women

Uterine leiomyomas (fibroids) affect 20–40% of reproductive age women and are the major indication for hysterectomy. Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) is a new, potentially disruptive, non-invasive and uterine-sparing treatment option that has been shown to yield similar or better clinical outcomes than other uterine-sparing interventions. However, the costs of MRgFUS and other minimally-invasive treatment options have not been studied using US practice data. This study attempts to fill this void. And since uterine fibroids are the first FDA-approved indication for MRgFUS treatment, this study may also have implications for other indications which are now investigational.

Reversal of Renal Insufficiency in an Aging Cat: A 5-year Multi-Crossover Case Study

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Robert Dennis ◽  
John Dennis
Keyword(s):  
Palliative Care ◽  
Renal Insufficiency ◽  
Treatment Options ◽  
Low Frequency ◽  
Standard Of Care ◽  
Omega 3 ◽  
Current Standard ◽  
Invasive Treatment ◽  
Non Invasive ◽  
Electro Magnetic

Renal failure is a leading cause of suffering and death in domestic cats, with approximately 1 in 3 cats affected.  Current standard-of-care treatment usually involves palliative care, diets restricted in protein and phosphorus, plenty of fluids, and sometimes vitamin D and Omega-3.  But even with early detection, which is difficult, treatment options are limited and often are not very effective.  Dietary restrictions and palliative care are often the best that can be offered, but the creatinine levels tend to inexorably creep upward toward eventual kidney failure and death.  We report the effectiveness of the use of a low-frequency, low-intensity, non-invasive treatment using Pulsed Electro-Magnetic Fields, specifically tuned to inductively generate micro-electric currents in deep tissues (ICES®-PEMF).  This report chronicles the return to normal and then reversion to renal insufficiency in a single cat, when ICES®-PEMF was applied, then withheld, then applied again, over three cycles of application and non-application, over a 5-year period. A return to normal creatinine levels, with a subsequent return to renal insufficiency as indicated by loss of control of creatinine, correlated precisely with the application and non-application of ICES®-PEMF.  The pattern observed during each cycle was as follows:  when applied 2 to 3 times weekly for 20-60 minutes each treatment, creatinine levels declined to normal range within 2-3 months.  During periods when treatment was discontinued, creatinine levels began to climb to high levels again.  We suggest the further study and potential use of ICES®-PEMF as an effective, inexpensive, safe, non-invasive treatment for feline kidney disease.

scholarly journals Modeling the effect of blunt impact on mitochondrial function in cartilage: implications for development of osteoarthritis

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e3468 ◽  
Author(s):  
Georgi I. Kapitanov ◽  
Bruce P. Ayati ◽  
James A. Martin
Keyword(s):  
Cell Viability ◽  
Mitochondrial Function ◽  
Treatment Options ◽  
Particle Swarm Algorithm ◽  
Invasive Treatment ◽  
Predictive Tool ◽  
Atp Production ◽  
Non Invasive ◽  
In Silico Studies ◽  
And Function

Objective Osteoarthritis (OA) is a disease characterized by degeneration of joint cartilage. It is associated with pain and disability and is the result of either age and activity related joint wear or an injury. Non-invasive treatment options are scarce and prevention and early intervention methods are practically non-existent. The modeling effort presented in this article is constructed based on an emerging biological hypothesis—post-impact oxidative stress leads to cartilage cell apoptosis and hence the degeneration observed with the disease. The objective is to quantitatively describe the loss of cell viability and function in cartilage after an injurious impact and identify the key parameters and variables that contribute to this phenomenon. Methods We constructed a system of differential equations that tracks cell viability, mitochondrial function, and concentrations of reactive oxygen species (ROS), adenosine triphosphate (ATP), and glycosaminoglycans (GAG). The system was solved using MATLAB and the equations’ parameters were fit to existing data using a particle swarm algorithm. Results The model fits well the available data for cell viability, ATP production, and GAG content. Local sensitivity analysis shows that the initial amount of ROS is the most important parameter. Discussion The model we constructed is a viable method for producing in silico studies and with a few modifications, and data calibration and validation, may be a powerful predictive tool in the search for a non-invasive treatment for post-traumatic osteoarthritis.

Non-Invasive Treatment of Adolescent Idiopathic Scoliosis: Systematic Literature Review by Using Citation Network Analysis

2020 ◽  
pp. 1-9
Author(s):  
Joanne Yip ◽  
Jason Pui-Yin Cheung ◽  
Joanne Yip ◽  
Kenneth Man-Chee Cheung ◽  
Kenny YatHong Kwan ◽  
...  
Keyword(s):  
Network Analysis ◽  
Literature Review ◽  
Treatment Options ◽  
Citation Network ◽  
Nonsurgical Treatment ◽  
Spinal Curvature ◽  
Invasive Treatment ◽  
Noninvasive Treatment ◽  
Non Invasive ◽  
Citation Network Analysis

There are many nonsurgical treatment options from adolescent idiopathic scoliosis (AIS) to control the progression of the spinal curvature. However, the existing studies are so diverse and diffuse that it is challenging to find potential trends for further studies without a more comprehensive review in place for reference purposes. Thus, the objective of this review article is to conduct a systematic literature review on the noninvasive treatment of AIS with a citation network analysis. The Web of Science (WoS) was searched using 9 reference keywords to collect published articles in English on nonsurgical treatment options for AIS from 1979 to 2019. Each eligible article focused on the nonsurgical options for treating AIS. In addition, the HistCite and the UCINet softwares were referred to for article distribution and citation network analysis. Only non-invasive treatment options of AIS were included. Studies that estimated the amount of spinal curvature, causes of or risk factors for AIS and any invasive treatments, such as surgery, were not focused on. The articles were independently extracted by 3 authors based on the predefined eligibility criteria. The title, authors, year of publication, country or region of publication, reference list, keywords and other bibliographic information from each article was extracted and analyzed purely based on the data with the HistCite and UCINet programs. At last, a total of 146 articles out of 1594 articles were selected for the literature review after the exclusion of 1357 irrelevant articles and 91 inappropriate studies, such as letters and proceedings papers. Of these 146 articles, the majority were empirical studies (74.0%). There was also a lack of meta-analyses in this research field. Based on the results of the citation network analysis, most of the top 10 articles with the highest local citation scores (LCSs) focused on bracing as a treatment. The popularity of bracing as a research topic was also supported by the citation network structure, as brace treatment was in the largest of the five research clusters; this cluster also included posture training through exercise, managing the corrective forces of braces, 3D analysis of braces and quality of life during brace treatment. However, most of these studies focused on rigid braces. A few studies on non-rigid braces and other types of nonsurgical treatment were available in the current literature, which might indicate potential research areas for future studies. To conclude, noninvasive treatment for AIS has been on the academic radar recently; but there are still research gaps, such as the lack of research on semi-rigid and flexible braces or posture training exercises with biofeedback systems. Further studies could explore these research directions.

Non-invasive versus invasive treatment options for challenging and progressive infundibulitis

2021 ◽  
Author(s):  
Jan P. Nieke ◽  
Maria I. Vargas ◽  
Patrick Meyer ◽  
Jörg D. Seebach ◽  
Peter Jandus
Keyword(s):  
Treatment Options ◽  
Invasive Treatment ◽  
Non Invasive

Effective Gait Modification Strategies for Offloading the Medial Compartment of the Knee

2008 ◽  
Author(s):  
Benjamin J. Fregly ◽  
Darryl D. D’Lima ◽  
Clifford W. Colwell
Keyword(s):  
Contact Force ◽  
Treatment Options ◽  
Medial Compartment ◽  
Invasive Treatment ◽  
Non Invasive ◽  
Trunk Sway ◽  
Total Knee ◽  
Highly Correlated ◽  
Gait Modification ◽  
Acid Test

Gait modification is a conservative, non-invasive treatment option for patients with medial compartment knee osteoarthritis. If proven effective for offloading the medial compartment, it may provide one of the few treatment options with disease modifying potential. Furthermore, it could fill an important therapeutic “hole” for patients in their 40’s and 50’s who no longer achieve sufficient pain relief through pharmacological means and yet are too young to receive a total knee replacement. A variety of gait modifications have been proposed for offloading the medial compartment, including toeing out [1], walking more slowly or with decreased stride length [2], walking with increased medial-lateral trunk sway [3], using lateral heel wedges [4], or walking with medialized knees [5]. These modifications have been proposed primarily based on their ability to reduce the external knee adduction torque. While this external measure is highly correlated with medial compartment contact force [6], the acid test is to demonstrate experimentally that a gait modification reduces medial contact force directly.

scholarly journals Laboratory Monitoring of Mother, Fetus, and Newborn in Hemolytic Disease of Fetus and Newborn

2021 ◽  
pp. 1-10
Author(s):  
Morten Hanefeld Dziegiel ◽  
Grethe Risum Krog ◽  
Anne Todsen Hansen ◽  
Marianne Olsen ◽  
Birgitte Lausen ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Peak Systolic Velocity ◽  
Screen Test ◽  
Current Approach ◽  
University Hospital ◽  
Laboratory Monitoring ◽  
Velocity Measurements ◽  
Hemolytic Disease ◽  
Non Invasive ◽  
Intrauterine Transfusion

<b><i>Background:</i></b> Laboratory monitoring of mother, fetus, and newborn in hemolytic disease of fetus and newborn (HDFN) aims to guide clinicians and the immunized women to focus on the most serious problems of alloimmunization and thus minimize the consequences of HDFN in general and of anti-D in particular. Here, we present the current approach of laboratory screening and testing for prevention and monitoring of HDFN at the Copenhagen University Hospital in Denmark. <b><i>Summary:</i></b> All pregnant women are typed and screened in the 1st trimester. This serves to identify the RhD-negative pregnant women who at gestational age (GA) of 25 weeks are offered a second screen test and a non-invasive fetal RhD prediction. At GA 29 weeks, and again after delivery, non-immunized RhD-negative women carrying an RhD-positive fetus are offered Rh immunoglobulin. If the 1st trimester screen reveals an alloantibody, antenatal investigation is initiated. This also includes RhD-positive women with alloantibodies. Specificity and titer are determined, the fetal phenotype is predicted by non-invasive genotyping based on cell-free DNA (RhD, K, Rhc, RhC, RhE, ABO), and serial monitoring of titer commences. Based on titers and specificity, monitoring with serial peak systolic velocity measurements in the fetal middle cerebral artery to detect anemia will take place. Intrauterine transfusion is given when fetal anemia is suspected. Monitoring of the newborn by titer and survival of fetal red blood cells by flow cytometry will help predict the length of the recovery of the newborn.

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