Elevated admission serum calcium phosphate product as an independent risk factor for acute kidney injury in hospitalized patients

2019 ◽  
Vol 47 (2) ◽  
pp. 73-79 ◽  
Author(s):  
Charat Thongprayoon ◽  
Wisit Cheungpasitporn ◽  
Michael A. Mao ◽  
Andrew M. Harrison ◽  
Stephen B. Erickson
Keyword(s):  
Acute Kidney Injury ◽  
Risk Factor ◽  
Calcium Phosphate ◽  
Serum Calcium ◽  
Independent Risk Factor ◽  
Kidney Injury ◽  
Hospitalized Patients ◽  
Phosphate Product

scholarly journals HYPOALBUMINEMIA, AN INDEPENDENT RISK FACTOR FOR ACUTE KIDNEY INJURY IN HOSPITALIZED PATIENTS: A META-ANALYSIS

CHEST Journal ◽  
2020 ◽  
Vol 158 (4) ◽  
pp. A655
Author(s):  
Panupong Hansrivijit ◽  
Keerthi Yarlagadda ◽  
Wisit Cheungpasitporn ◽  
Charat Thongprayoon ◽  
Nasrollah Ghahramani
Keyword(s):  
Acute Kidney Injury ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Meta Analysis ◽  
Kidney Injury ◽  
Hospitalized Patients

scholarly journals Incidence and Predictors of Acute Kidney Injury Among Women With Severe Pre-eclampsia at Mbarara Regional Referral Hospital

2021 ◽  
Author(s):  
Mariam Hassan ◽  
Roland Mayanja ◽  
Wasswa G.M Ssalongo ◽  
Natumanya Robert ◽  
Lugobe Henry Mark ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Risk Factor ◽  
Serum Creatinine ◽  
Independent Risk Factor ◽  
Statistical Significance ◽  
Kidney Injury ◽  
Referral Hospital ◽  
Chronic Hypertension ◽  
Baseline Serum ◽  
Regional Referral Hospital

Abstract BackgroundThe presence of acute kidney injury (AKI) in pre-eclampsia complicates treatment including; increasing length of hospital stay and a need to access services like dialysis which are largely expensive in resource-limited settings. We aimed to determine incidence and predictors of acute kidney injury among women with severe pre-eclampsia at Mbarara Regional Referral Hospital in southwestern Uganda. MethodsWe carried out a hospital-based prospective cohort study from 16 November 2018 to 18 April 2019, among pregnant women with severe preeclampsia followed up in the hospital. We enrolled 70 mothers with severe pre-eclampsia and eclampsia; we excluded patients with a history of chronic renal disease, chronic hypertension, and gestational hypertension.Data on socio-demographics, laboratory parameters, health system, obstetric and medical factors were collected. Baseline serum creatinine, complete blood count, and CD4 T-cell count were all done at admission (0-hour). Second serum creatinine was done at 48-hours to determine the presence of AKI. AKI was defined as a rise in serum creatinine of 0.3mg/dl or more from the baseline. The proportion of women diagnosed with acute kidney injury among the total number of women with severe pre-eclampsia was reported as incidence proportion. Univariate and multivariate logistic regression was used to establish the association of acute kidney injury and severe pre-eclampsia.ResultsIncidence of acute kidney injury was high (41.4%) among women with severe pre-eclampsia. Antenatal care attendance was protective 0.36 (0.16, 0.80), p<0.013 at bivariate analysis but had no statistical significance at multivariate analysis. Eclampsia was an independent risk factor for acute kidney injury. (aRR 2.74 (1.06, 7.08), P<0. 037.ConclusionThe incidence of acute kidney injury in patients with preeclampsia is high. Eclampsia is an independent risk factor of acute kidney injury.

Specific diseases: renal disease

ESC CardioMed ◽  
2018 ◽  
pp. 2670-2673
Author(s):  
Susanna Price
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Acute Kidney Injury ◽  
Risk Factor ◽  
Kidney Disease ◽  
Renal Disease ◽  
Independent Risk Factor ◽  
Hospital Admissions ◽  
Kidney Injury ◽  
Potential Methods

Chronic kidney disease is a global health burden, with an estimated prevalence of 11–13%, with the majority of patients diagnosed as stage 3, and is an independent risk factor for cardiovascular disease. The incidence of acute kidney injury is increasing, and estimated to be present in one in five acute hospital admissions, and there is a bidirectional relationship between acute and chronic kidney disease. The relevance to the patient with cardiovascular disease relates to increased perioperative risk, as reduced kidney function is an independent risk factor for adverse postoperative cardiovascular outcomes including myocardial infarction, stroke, and progression of heart failure. Furthermore, patients undergoing cardiovascular investigations are at risk of developing acute kidney injury, in particular where iodinated contrast is administered. This chapter reviews the classification of renal disease and its impact on cardiovascular disease, as well as potential methods for reducing the development of contrast-induced acute kidney injury.

scholarly journals Immunopathology of Acute Kidney Injury in Severe Malaria

2021 ◽  
Vol 12 ◽  
Author(s):  
Orestis Katsoulis ◽  
Athina Georgiadou ◽  
Aubrey J. Cunnington
Keyword(s):  
Acute Kidney Injury ◽  
Risk Factor ◽  
Inflammatory Response ◽  
Severe Malaria ◽  
Independent Risk Factor ◽  
Microvascular Obstruction ◽  
Kidney Injury ◽  
Systemic Effects ◽  
Intravascular Hemolysis ◽  
Host Inflammatory Response

Acute kidney injury (AKI) is a common feature of severe malaria, and an independent risk factor for death. Previous research has suggested that an overactivation of the host inflammatory response is at least partly involved in mediating the kidney damage observed inP. falciparumpatients with AKI, however the exact pathophysiology of AKI in severe malaria remains unknown. The purpose of this mini-review is to describe how different aspects of malaria pathology, including parasite sequestration, microvascular obstruction and extensive intravascular hemolysis, may interact with each other and contribute to the development of AKI in severe malaria, by amplifying the damaging effects of the host inflammatory response. Here, we highlight the importance of considering how the systemic effects and multi-organ involvement of malaria are intertwined with the localized effects on the kidney.

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