GAN-based clustering solution generation and fusion of diffusion

AbstractCaveolae are spherically shaped nanodomains of the plasma membrane, generated by cooperative assembly of caveolin and cavin proteins. Cavins are cytosolic peripheral membrane proteins with negatively charged intrinsically disordered regions that flank positively charged α-helical regions. Here, we show that the three disordered domains of Cavin1 are essential for caveola formation and dynamic trafficking of caveolae. Electrostatic interactions between disordered regions and α-helical regions promote liquid-liquid phase separation behaviour of Cavin1 in vitro, assembly of Cavin1 oligomers in solution, generation of membrane curvature, association with caveolin-1, and Cavin1 recruitment to caveolae in cells. Removal of the first disordered region causes irreversible gel formation in vitro and results in aberrant caveola trafficking through the endosomal system. We propose a model for caveola assembly whereby fuzzy electrostatic interactions between Cavin1 and caveolin-1 proteins, combined with membrane lipid interactions, are required to generate membrane curvature and a metastable caveola coat.

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An Elaborate Preprocessing Phase (p3) in Composition and Optimization of Business Process Models

Computation ◽

10.3390/computation9020016 ◽

2021 ◽

Vol 9 (2) ◽

pp. 16

Author(s):

George Tsakalidis ◽

Kostas Georgoulakos ◽

Dimitris Paganias ◽

Kostas Vergidis

Keyword(s):

Computational Complexity ◽

Business Process ◽

Synthetic Data ◽

Search Space ◽

Positive Influence ◽

Process Models ◽

Library Size ◽

Solution Generation ◽

Improved Performance ◽

Business Process Optimization

Business process optimization (BPO) has become an increasingly attractive subject in the wider area of business process intelligence and is considered as the problem of composing feasible business process designs with optimal attribute values, such as execution time and cost. Despite the fact that many approaches have produced promising results regarding the enhancement of attribute performance, little has been done to reduce the computational complexity due to the size of the problem. The proposed approach introduces an elaborate preprocessing phase as a component to an established optimization framework (bpoF) that applies evolutionary multi-objective optimization algorithms (EMOAs) to generate a series of diverse optimized business process designs based on specific process requirements. The preprocessing phase follows a systematic rule-based algorithmic procedure for reducing the library size of candidate tasks. The experimental results on synthetic data demonstrate a considerable reduction of the library size and a positive influence on the performance of EMOAs, which is expressed with the generation of an increasing number of nondominated solutions. An important feature of the proposed phase is that the preprocessing effects are explicitly measured before the EMOAs application; thus, the effects on the library reduction size are directly correlated with the improved performance of the EMOAs in terms of average time of execution and nondominated solution generation. The work presented in this paper intends to pave the way for addressing the abiding optimization challenges related to the computational complexity of the search space of the optimization problem by working on the problem specification at an earlier stage.

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Collaborative idea exchange and material tinkering influence families’ creative engineering practices and products during engineering programs in informal learning environments

Information and Learning Sciences ◽

10.1108/ils-02-2020-0031 ◽

2021 ◽

Vol ahead-of-print (ahead-of-print) ◽

Author(s):

Soo Hyeon Kim ◽

Heather Toomey Zimmerman

Keyword(s):

Design Research ◽

Naturalistic Inquiry ◽

Content Type ◽

Engineering Programs ◽

Solution Generation ◽

Quantitative Analyses ◽

Feasible Solutions ◽

Engineering Practices ◽

Parent Child

Purpose This paper aims to investigate how families’ sociomaterial experiences in engineering programs held in libraries and a museum influence their creative engineering practices and the creativity expressed in their products derived from their inquiry-driven engineering activities. Design/methodology/approach This research project takes a naturalistic inquiry using qualitative and quantitative analyses based on video records from activities of 31 parent–child pairs and on creativity assessment of products that used littleBits as prototyping tools. Findings Families engaged in two sociomaterial experiences related to engineering – collaborative idea exchange and ongoing generative tinkering with materials – which supported the emergence of novel ideas and feasible solutions during the informal engineering programs. Families in the high novelty score group experienced multiple instances of collaborative idea exchange and ongoing generative tinkering with materials, co-constructed through parent-child collaboration, that were expansive toward further idea and solution generation. Families in the low novelty score group experienced brief collaborative idea exchange and material tinkering with specific idea suggestions and high involvement from the parent. An in-depth case study of one family further illustrated that equal engagement by the parent and child as they tinkered with the technology supported families’ creative engineering practices. Originality/value This analysis adds to the information sciences and learning sciences literatures with an account that integrates methodologies from sociocultural and engineering design research to understand the relationship between families’ engagement in creative engineering practices and their products. Implications for practitioners include suggestions for designing spaces to support families’ collaborative idea exchange and ongoing generative tinkering to facilitate the development of creative engineering practices during short-term engineering programs.

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Modifying CBT to Meet the Challenge of Treating Emotion Dysregulation

The Oxford Handbook of Dialectical Behaviour Therapy ◽

10.1093/oxfordhb/9780198758723.013.6 ◽

2018 ◽

pp. 106-118

Author(s):

Jennifer H. R. Sayrs ◽

Marsha M. Linehan

Keyword(s):

Emotion Dysregulation ◽

World View ◽

Therapy Session ◽

Behaviour Therapy ◽

Dialectical Behaviour Therapy ◽

Essential Component ◽

Solution Generation ◽

Flexible Thinking

Dialectics are a cornerstone of dialectical behaviour therapy (DBT; Linehan, 1993), and are considered an essential component of treating emotion dysregulation. Incorporating dialectics may enhance therapeutic collaboration, increase flexible thinking, and maximize solution generation. This chapter briefly describes a dialectical world view, then lays out steps for incorporating dialectics into a therapy session, including adopting a dialectical world view, maintaining balance in treatment, working toward synthesis whenever polarization occurs, and utilizing dialectical strategies. Dialectical strategies are any strategies that involve looking for what is left out, synthesizing two poles, and allowing the synthesis to move the interaction forward to a new position. These strategies include magnifying the tension between opposites (such as devil’s advocate and extending strategies), entering the paradox (such as ‘and versus but’ and ‘making lemonade out of lemons’ strategies), and the use of metaphors. While these strategies were developed within DBT, other treatments utilize dialectical approaches, as well.

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How rewards fuel or fail innovation

Strategic HR Review ◽

10.1108/shr-11-2018-0091 ◽

2019 ◽

Vol 18 (1) ◽

pp. 8-12

Author(s):

Susan Kuczmarski ◽

Thomas Kuczmarski

Keyword(s):

Qualitative Interviews ◽

Innovation Process ◽

Field Research ◽

High Tech ◽

Collaborative Culture ◽

Content Type ◽

Team Members ◽

Self Confidence ◽

Solution Generation ◽

Self Worth

Purpose The purpose of our research is to explore how rewards serve to fuel a collaborative culture, energize and motivate team members and nurture innovation. Design/methodology/approach In total, 30 in-depth, qualitative interviews were conducted with executives – high-tech, low-tech and no-tech. Findings The following findings emerged from the field research: rewards can be both financial, such as bonuses and incentives, and non-financial, such as extra vacations or other gifts. Huge internal personal benefits accrue from setting up a reward structure, including increased pride, peer recognition, higher self-confidence, greater job satisfaction and enhanced self-accomplishment. When we recognize others, it can impact an individual's self-worth on a profound level. It is described as feedback that sinks into the core. Originality/value Three milestones have been outlined throughout the innovation process where opportunities for recognition can exist: upon recognizing insights for identifying a problem, after understanding and overcoming difficulties encountered during creative solution generation and when recognizing and activating the benefits accrued from pinpointing solutions to the problem.

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Ionic reactions of polymers in solution—Generation and characterization of ion radicals of polymers

International Journal of Radiation Applications and Instrumentation Part C Radiation Physics and Chemistry ◽

10.1016/1359-0197(90)90251-c ◽

1990 ◽

Vol 36 (2) ◽

pp. 243-247

Author(s):

Migaku Tanaka ◽

Masaaki Ogasawara ◽

Hiroshi Yoshida

Keyword(s):

Solution Generation ◽

Ionic Reactions

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Exploration of the Dynamics of Neuro-Cognition During TRIZ

10.1115/detc2021-70412 ◽

2021 ◽

Author(s):

Julie Milovanovic ◽

Mo Hu ◽

Tripp Shealy ◽

John Gero

Keyword(s):

Engineering Design ◽

Engineering Students ◽

Cognitive Differences ◽

Cognitive Activation ◽

Solution Generation ◽

Engineering Parameters ◽

Medial Pfc ◽

The Right ◽

Support Engineering ◽

Structured Approach

Abstract The Theory of Inventive Problem Solving (TRIZ) method and toolkit provides a well-structured approach to support engineering design with pre-defined steps: interpret and define the problem, search for standard engineering parameters, search for inventive principles to adapt, and generate final solutions. The research presented in this paper explores the neuro-cognitive differences of each of these steps. We measured the neuro-cognitive activation in the prefrontal cortex (PFC) of 30 engineering students. Neuro-cognitive activation was recorded while students completed an engineering design task. The results show a varying activation pattern. When interpreting and defining the problem, higher activation is found in the left PFC, generally associated with goal directed planning and making analytical. Neuro-cognitive activation shifts to the right PFC during the search process, a region usually involved in exploring the problem space. During solution generation more activation occurs in the medial PFC, a region generally related to making associations. The findings offer new insights and evidence explaining the dynamic neuro-cognitive activations when using TRIZ in engineering design.

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