Maternal influenza vaccination relates to receiving relevant information among pregnant women in Japan

Abstract Background Although the World Health Organization and health authorities in most countries recommend that pregnant women receive inactivated influenza virus vaccines, coverage remains low. This study aimed to investigate (1) the proportion of pregnant women who received an influenza vaccination and influencing factors and (2) the proportion of obstetrics and gynecology (OBGYN) doctors who routinely recommend influenza vaccination to pregnant women and influencing factors. Methods Two separate, anonymized questionnaires were developed for physicians and pregnant and postpartum women and were distributed to multicenters and clinics in South Korea. The proportions of women who received influenza vaccination during pregnancy and OBGYN doctors who routinely recommend the influenza vaccine to pregnant women were analyzed. Independent influencing factors for both maternal influenza vaccination and OBGYN doctors’ routine recommendations to pregnant women were analyzed using log-binomial regression analysis. Results The proportion of self-reported influenza vaccination during pregnancy among 522 women was 63.2%. Pregnancy-related independent factors influencing maternal influenza vaccination were “(ever) received information about influenza vaccination during pregnancy” (OR 8.9, 95% CI 4.17–19.01), “received vaccine information about from OBGYN doctors” (OR 11.44, 95% CI 5.46–24.00), “information obtained from other sources” (OR 4.38, 95% CI 2.01–9.55), and “second/third trimester” (OR 2.41, 95% CI 1.21–4.82).. Among 372 OBGYN doctors, 76.9% routinely recommended vaccination for pregnant women. Independent factors effecting routine recommendation were “working at a private clinic or hospital” (OR 5.33, 95% CI 2.44–11.65), “awareness of KCDC guidelines” (OR 3.11, 95% CI 1.11–8.73), and “awareness of the 2019 national free influenza vaccination program for pregnant women” (OR 4.88, 95% CI 2.34–10.17). OBGYN doctors most commonly chose ‘guidelines proposed by the government or public health (108, 46%) and academic committees (59, 25%), as a factor which expect to affect the future recommendation Conclusion This study showed that providing information about maternal influenza vaccination, especially by OBGYN doctors, is crucial for increasing vaccination coverage in pregnant women. Closer cooperation between the government and OBGYN academic societies to educate OBGYN doctors might enhance routine recommendations.

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2738. Influenza Vaccination During Pregnancy Among Mothers of Infants with Acute Respiratory Illness, United States, 2016–2018

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.2416 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S963-S964

Author(s):

Constance E Ogokeh ◽

Manish Patel ◽

Joana Y Lively ◽

Mary A Staat ◽

Geoffrey A Weinberg ◽

...

Keyword(s):

Influenza Vaccine ◽

Influenza Vaccination ◽

Pregnant Women ◽

Influenza Season ◽

Respiratory Illness ◽

Vaccine Safety ◽

Acute Respiratory Illness ◽

Surveillance Network ◽

Vaccination History ◽

Maternal Influenza

Abstract Background Influenza vaccination has been shown to reduce influenza risk in pregnant women and their infants who are not yet age-eligible for vaccine. Ascertainment of vaccination history is important for vaccine safety and effectiveness evaluations. Our goals were to (a) determine coverage, location, and timing of maternal influenza vaccination and (b) compare a subset of self-reported influenza vaccinations with documented vaccine records. Methods We enrolled children < 18 years. with acute respiratory illness in 7 pediatric hospitals and emergency departments in the New Vaccine Surveillance Network from December 1, 2016 to October 31, 2018. We interviewed all mothers of enrolled infants < 1 year, and obtained mother’s influenza vaccine information while pregnant. As an option, sites obtained maternal influenza vaccine records from reported sources (e.g., registries, provider records, pharmacies). Results Among 5,458 mothers, 2,944 (54%) self-reported receiving influenza vaccine during pregnancy (57% in 2016–2017; 51% in 2017–2018), varying from 49% to 74% by site. Among self-reported vaccinees, 17%, 36%, and 47% received vaccine during their first, second, and third trimester, respectively. Most women (76%) were vaccinated at their OB/GYN or midwife office, 7% at their primary care provider, 7% at their workplace, and 5% at a retail pharmacy. Among 1,338 infants < 6 months. during early influenza season (i.e., born from June to August) and thus ineligible for vaccination, only 46% of mothers reported receiving vaccine during pregnancy (42% reported not receiving it, 12% were unsure). Of 2,242 women for whom vaccine verification was attempted, 1,491 (67%) self-reported receiving influenza vaccine during pregnancy; of those, documentation of vaccine receipt was found for 901 (60%). Conclusion Influenza vaccination coverage among pregnant women was suboptimal, potentially increasing the risk of influenza in unvaccinated pregnant women. Infants born to unvaccinated women, particularly those born from June to August, may also be at higher risk since they are not age-eligible to receive vaccine before influenza season. The optimal approach to ascertainment of maternal vaccination history with accuracy and completeness merits further investigation. Disclosures All authors: No reported disclosures.

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Influenza Vaccination During Pregnancy And Influencing Factors In Korea: A Multicenter Questionnaires Study of Pregnant Women and Obstetrics and Gynecology Doctors.

10.21203/rs.3.rs-76094/v1 ◽

2020 ◽

Author(s):

Byung Soo Kang ◽

San Ha Lee ◽

Woo Jeng Kim ◽

Jeong Ha Wie ◽

In Yang Park ◽

...

Keyword(s):

Influenza Vaccine ◽

Influenza Vaccination ◽

Pregnant Women ◽

Influencing Factors ◽

Multivariate Logistic Regression Analysis ◽

Public Health Care ◽

Vaccination Program ◽

Obstetrics And Gynecology ◽

The Government ◽

Maternal Influenza

Abstract BackgroundOur objective was to investigate: (1) the proportion of influenza vaccination, attitudes, and barriers among pregnant women, (2) the proportion of obstetrics and gynecology (OBGYN) doctors who routinely recommend influenza vaccination in pregnant women, and (3) the influencing factors in Korea, during the flu season of 2019-2020, following the introduction of free influenza vaccination program for pregnant women.MethodsTwo separate anonymized questionnaires were developed for pregnant or postpartum women and physicians, and distributed to public or private healthcare centers and clinics, in South Korea. The proportions of women who received influenza vaccination during pregnancy and OBGYN doctors who routinely recommend influenza vaccine for pregnant women were analyzed. Independent influencing factors of influenza vaccination and OBGYN doctors’ routine recommendation for pregnant women were analyzed using multivariate logistic regression analysis, respectively.Result The self-reported proportion of influenza vaccination during pregnancy among 522 women was 63.2%. Independent factors influencing maternal influenza vaccination were ‘(ever) received information about influenza vaccination during pregnancy’, ‘information obtained from OBGYN doctors’, and ‘2nd/3rd trimester or postpartum period’ (OR 8.988, 95% CI 4.21–19.188, p < 0.001, OR 2.611, 95% CI 1.705-3.998, p < 0.001 and OR 3.082, 95% CI 1.508–6.297, p < 0.001, respectively).In 372 OBGYN doctors, the proportion of doctors with the routine recommendation of influenza vaccine for pregnant women was 76.9%. Independent factors affecting the routine recommendation were: 1) affiliation with private hospital or clinic (OR 4.508, 95% CI 2.225–9.133, p<0.001); 2) awareness of guidelines (OR 3.153, 95% CI 1.118–8.894, p=0.03); (3) awareness of 2019 National free influenza vaccination program for pregnant women (OR 4.955, 95%CI 2.377–10.329, p<0.001). For a future recommendation of influenza vaccine for pregnant women, the guidelines proposed by the government or public health care [108 (46%)] and academic committees [59 (25%)] were most commonly chosen by OBGYN doctors.Conclusion This study demonstrated that providing information about maternal influenza vaccination and the recommendation by OBGYN doctors are crucial for increasing the vaccination coverage in pregnant women.

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Influenza and Tetanus, Diphtheria, and Acellular Pertussis Vaccination During Pregnancy, Pregnancy Risk Assessment Monitoring System, 2019

10.21203/rs.3.rs-1217686/v1 ◽

2022 ◽

Author(s):

Titilope Oduyebo ◽

Katie Kortsmit ◽

Regina Simeone ◽

Katherine Kahn ◽

Hilda Razzaghi ◽

...

Keyword(s):

Risk Assessment ◽

Influenza Vaccine ◽

Influenza Vaccination ◽

Pregnant Women ◽

Healthcare Provider ◽

Monitoring System ◽

Rhode Island ◽

Pregnancy Risk ◽

Maternal Characteristics ◽

Maternal Influenza

Abstract Background Influenza and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines is recommended for pregnant women to protect themselves and their infants from adverse health outcomes. Objectives To estimate the prevalence of maternal influenza and Tdap vaccination and determine factors associated with receipt of these vaccines. Methods We analyzed 2019 data from the Pregnancy Risk Assessment Monitoring System, from 43 jurisdictions. We estimated the overall prevalence of women reporting receipt of a healthcare provider offer or recommendation for influenza vaccine (n=44,528), and influenza vaccine during the 12 months before delivery (n=44,213). We also estimated Tdap vaccine receipt during pregnancy from the 21 jurisdictions (n=22,972). Maternal influenza and Tdap vaccination were examined by selected maternal characteristics and by jurisdiction. Results Overall, 86.4% of women reported being offered or recommended an influenza vaccination, and 60.8% of women reported receiving an influenza vaccination in the 12 months prior to their delivery, ranging from 36.0% in Puerto Rico to 82.1% in Rhode Island. Tdap receipt during pregnancy was 73.7%, ranging from 52.2% in Mississippi to 85.1% in Vermont. Prevalence of influenza vaccination was lower among women aged 18–24 years (52.2%), who are non-Hispanic black (44.5%), with a high school diploma or less education (51.3%), with no prenatal insurance (43.2%), having no (42.0%) prenatal care, with ≥3 previous live births (49.3%) and not offered or recommended the influenza vaccine by a healthcare provider (20.0%). Tdap vaccination also varied by all characteristics examined and was lower among similar groups of women observed to have lower influenza vaccination uptake. Conclusion In 2019, influenza and Tdap vaccination were suboptimal among women with a recent live birth. It is important that U.S. jurisdictions provide equitable access to these vaccines during pregnancy. These results may also inform efforts for vaccination for other infectious diseases among pregnant women.

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Using record linkage to demonstrate the benefits of maternal influenza immunisation in Western Australia

International Journal for Population Data Science ◽

10.23889/ijpds.v1i1.201 ◽

2017 ◽

Vol 1 (1) ◽

Author(s):

Annette Regan ◽

Hannah Moore ◽

Nicholas De Klerk ◽

Geoffrey Shellam ◽

Paul Effler

Keyword(s):

Influenza Vaccination ◽

Pregnant Women ◽

Birth Outcomes ◽

Western Australia ◽

Cox Regression ◽

Neonatal Health ◽

Hospital Inpatient ◽

Adverse Birth Outcomes ◽

Maternal Immunisation ◽

Maternal Influenza

ABSTRACTObjectivesPregnant women are the highest priority for seasonal influenza vaccination. Previous research has found maternal immunisation may not only reduce respiratory infections in mothers and infants, but also prevents adverse birth outcomes. Although the vaccine has been offered to pregnant women under the National Immunisation Program since 2009, no population-based study has yet evaluated its impact on neonatal health in Australia. ApproachWe established a large retrospective cohort of 58,615 births between 2012 and 2013 in Western Australia using data linkage of state-held maternal vaccination records, birth registrations, hospital inpatient records, and midwives notifications. Cox regression models were used to compare the adjusted relative hazard (HR) of adverse birth outcomes and hospital admission for an acute respiratory illness (ARI) by vaccination status. ResultsIn total, 5,241 (8.9%) of infants were born to vaccinated mothers. Between 2012 and 2013, there were 23.6 ARI admissions per 1,000 infants <6 months and 2.8 ARI admissions per 1,000 pregnant women. Influenza vaccination was associated with a 51% reduction in stillbirth (aHR: 0.49; 95% CI: 0.29-0.84) and a 25% reduction in infant admissions in the first six months of life (aHR: 0.75; 95% CI: 0.56-0.99). Most of the reduction in ARI admission in infants was observed when vaccination occurred in the third trimester (aHR: 0.68; 95% CI: 0.47-0.95). ConclusionsOur findings support the neonatal health benefits afforded by maternal influenza immunisation and underscore the importance of offering and promoting influenza vaccination to pregnant women. Considering more than 90% of women who choose to be immunised do so to protect their infant, these results could be used to powerfully promote maternal immunisation.

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Coverage and Timing of Influenza Vaccination Among Privately Insured Pregnant Women in the United States, 2010-2018

Public Health Reports ◽

10.1177/00333549211026779 ◽

2021 ◽

pp. 003335492110267

Author(s):

Kai Hong ◽

Megan C. Lindley ◽

Fangjun Zhou

Keyword(s):

Influenza Vaccination ◽

Pregnant Women ◽

Vaccination Coverage ◽

Influenza Season ◽

The United States ◽

Metropolitan Statistical Area ◽

Provider Education ◽

Vaccination Uptake ◽

Increased Risk ◽

Privately Insured

Objective Pregnant women are at increased risk of serious complications from influenza and are recommended to receive an influenza vaccination during pregnancy. The objective of this study was to assess trends, timing patterns, and associated factors of influenza vaccination among pregnant women. Methods We used 2010-2018 MarketScan data on 1 286 749 pregnant women aged 15-49 who were privately insured to examine trends and timing patterns of influenza vaccination coverage. We examined descriptive statistics and identified factors associated with vaccination uptake by using multivariate log-binomial and Cox proportional hazard models. Results In-plan influenza vaccination coverage before delivery increased from 22.0% during the 2010-2011 influenza season to 33.2% during the 2017-2018 influenza season. About two-thirds of vaccinated women received the vaccine in September or October during each influenza season. For women who delivered in September through May, influenza vaccination coverage increased rapidly at the beginning of influenza season and flattened after October. For women who delivered in June through August, influenza vaccination coverage increased gradually until February and flattened thereafter. Most vaccinated women who delivered before January received the vaccine in the third trimester. Increased likelihood of being vaccinated was associated with age 31-40, living in a metropolitan statistical area, living outside the South, enrollment in a consumer-driven or high-deductible health plan, being spouses or dependents of policy holders, and delivery in November through January. Conclusions Despite increases during the past several years, vaccination uptake is still suboptimal, particularly after October. Health care provider education on timing of vaccination and recommendations throughout influenza seasons are needed to improve influenza vaccination coverage among pregnant women.

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Efficacy and safety of influenza vaccination during pregnancy: realizing the potential of maternal influenza immunization

Expert Review of Vaccines ◽

10.1080/14760584.2021.1915138 ◽

2021 ◽

Author(s):

Annette K Regan ◽

Flor M. Munoz

Keyword(s):

Influenza Vaccination ◽

Efficacy And Safety ◽

Influenza Immunization ◽

Maternal Influenza

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31. Influenza Vaccination During Pregnancy: A Descriptive Cross-sectional Survey of the Knowledge, Beliefs, and Attitudes of Mexican Gynecologists and Family Physicians

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa439.076 ◽

2020 ◽

Vol 7 (Supplement_1) ◽

pp. S39-S39

Author(s):

Erika Z Lopatynsky-Reyes ◽

Sue Ann Costa-Clemens ◽

Enrique Chacon-Cruz ◽

Michael Greenberg

Keyword(s):

Influenza Vaccination ◽

Pregnant Women ◽

Latin American ◽

Vaccine Coverage ◽

Family Physicians ◽

Morbidity And Mortality ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Beliefs And Attitudes ◽

In Pregnancy

Abstract Background Influenza in pregnancy is associated with elevated morbidity and mortality. Influenza vaccines are both safe and effective in pregnancy, supporting routine use in this population. Even though influenza vaccination in Mexico is recommended for pregnant women, there are no publications of influenza vaccine coverage in pregnancy. This is the first Latin American survey done only in physicians aiming to assess the knowledge, beliefs, and attitudes that Mexican Obstetrics-Gynecologists (OBG) and Family Physicians (FP) have towards influenza and influenza immunization during pregnancy. Methods A cross-sectional survey was conducted, both paper-based and online. The questionnaire was composed of 35 questions, which addressed general knowledge of influenza, recommendations for vaccination during pregnancy, and beliefs and attitudes concerning the acceptability of the vaccine in pregnant women. Results A total of 206 completed surveys were available, 98 (47.6%) from OBG, 108 (52.4%) from FP. Regarding current practicing medical institutions, 76 (37%), 69 (34%), 31 (14.5%), 30 (14.5%) reported working for the Mexican Institute of Social Security, Private Sector, Secretariat of Health, or a combination of all respectively, representing an estimated 2,472 daily pregnancy consultations. About a quarter (26.2%) reported not having a notion that influenza is more severe among pregnant women. More than half (51.5%) ignored the potential side effects of influenza infection on the fetus. The majority (56.8%) did not know when vaccination during pregnancy should occur. Pregnancy as a risk factor for developing influenza complications was known only in 48.1%. Also, 46.1 % believed that vaccination only confers protection to the mother, but not to the fetus. Nevertheless, 96.1% considered that immunization against influenza during pregnancy is a safe and effective preventive intervention. A results’ summary is shown in Figure-1. Conclusion Based on this survey, current knowledge of OBG and FP for influenza morbidity and mortality during pregnancy, and the importance of influenza vaccination in pregnant women, is poor. Mandatory recommendations to educate medical providers regarding influenza vaccination during pregnancy in Mexico are necessary, even as imperative for CME credits. Disclosures All Authors: No reported disclosures

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