scholarly journals Knockdown of circular RNA septin 9 inhibits the malignant progression of breast cancer by reducing the expression of solute carrier family 1 member 5 in a microRNA-149-5p-dependent manner

Bioengineered ◽  
2021 ◽  
Author(s):  
Jianjun Wang ◽  
Kunxian Yang ◽  
Junyu Cao ◽  
Li Li
Keyword(s):  
Breast Cancer ◽  
Circular Rna ◽  
Malignant Progression ◽  
Dependent Manner ◽  
Solute Carrier Family ◽  
Septin 9 ◽  
Solute Carrier

scholarly journals Differential expression of solute carrier family 29 member 4 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Differentially Expressed Gene ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Solute Carrier Family ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Solute Carrier

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding solute carrier family 29 member 4, SLC29A4, when comparing primary tumors of the breast to the tissue of origin, the normal breast. SLC29A4 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of SLC29A4 in primary tumors of the breast was correlated with overall survival in patients with luminal B subtype cancer and in patients with normal-like subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. SLC29A4 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of solute carrier family 22 member 3 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Solute Carrier Family ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Her2 Breast Cancer ◽  
Solute Carrier

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding solute carrier family 22 member 3, SLC22A3, when comparing primary tumors of the breast to the tissue of origin, the normal breast. SLC22A3 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of SLC22A3 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal B subtype breast cancer, but not in patients with luminal A or HER2+ breast cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. SLC22A3 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Solute Carrier Family 27 Member 4 (SLC27A4) Enhances Cell Growth, Migration, and Invasion in Breast Cancer Cells

2018 ◽  
Vol 19 (11) ◽  
pp. 3434 ◽  
Author(s):  
Meng-Chi Yen ◽  
Shih-Kai Chou ◽  
Jung-Yu Kan ◽  
Po-Lin Kuo ◽  
Ming-Feng Hou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cell Lines ◽  
Breast Cancer Cells ◽  
Migration And Invasion ◽  
Fatty Acid Transport ◽  
Solute Carrier Family ◽  
Solute Carrier

Fatty acid metabolism is important in the regulation of breast cancer progression. Some of the proteins involved in fatty acid transport have been demonstrated to promote the proliferation, migration, and invasion in breast cancer cells. Solute carrier family 27 member 4 (SLC27A4) is a fatty acid transporter protein and is related to very long chain acyl-CoA synthetase activity. In the present study, bioinformatic analysis revealed that relatively high SLC27A4 expression was observed in all subtypes of breast tumor tissues when compared to normal breast tissues. Silencing SLC27A4 expression significantly reduced uptake of free fatty acids in two breast cancer cell lines, Hs578T and MDA-MB-231. Cell growth inhibition was observed in SLC27A4-silenced Hs578T and cell cycle was arrested at G2/M. In addition, the capacity of migration and invasion decreased in both cell lines after knockdown of SLC27A4. The epithelial–mesenchymal transition signaling pathway was inhibited because protein expression of Slug, vimentin, α-smooth muscle actin, and other regulators was lower than that in control cells. Taken together, our results confirm that high SLC27A4 is associated with tumor progression in breast cancer cells. It is worth investigating whether SLC27A4 serves a diagnostic marker and therapeutic target in further studies.

scholarly journals Differential expression of solute carrier family 19 member 3 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Differentially Expressed Gene ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Solute Carrier Family ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Solute Carrier

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding solute carrier family 19 member 3, SLC19A3, when comparing primary tumors of the breast to the tissue of origin, the normal breast. SLC19A3 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of SLC19A3 in primary tumors of the breast was correlated with overall survival in patients with normal-like subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. SLC19A3 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of solute carrier family 7 member 10 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Differentially Expressed Gene ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Solute Carrier Family ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Solute Carrier

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding solute carrier family 7 member 10, SLC7A10, when comparing primary tumors of the breast to the tissue of origin, the normal breast. SLC7A10 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of SLC7A10 in primary tumors of the breast was correlated with overall survival in patients with basal-like, HER2+ and normal-like subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. SLC7A10 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of solute carrier family 16 member 7 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Differentially Expressed Gene ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Solute Carrier Family ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Solute Carrier

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding solute carrier family 16 member 7, SLC16A7, when comparing primary tumors of the breast to the tissue of origin, the normal breast. SLC16A7 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. SLC16A7 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of SLC16A7 in primary tumors of the breast was correlated with overall survival in patients with basal-like subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. SLC16A7 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals SLC6A8 Knockdown Suppresses the Invasion and Migration of Human Hepatocellular Carcinoma Huh-7 and Hep3B Cells

2020 ◽  
Vol 19 ◽  
pp. 153303382098302
Author(s):  
Lu Yuan ◽  
Xian Jian Wu ◽  
Wen Chuan Li ◽  
Chenyi Zhuo ◽  
ZuoMing Xu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Vital Role ◽  
Human Hepatocellular Carcinoma ◽  
Migration And Invasion ◽  
Dependent Manner ◽  
Solute Carrier Family ◽  
Invasion And Migration ◽  
Behavioral Abnormalities ◽  
Solute Carrier ◽  
Induced Apoptosis

Liver cancer is considered the sixth most commonly diagnosed cancer and the fourth leading cause of cancer-related deaths worldwide. Currently, there is no specific and effective therapy for hepatocellular carcinoma. Therefore, developing novel diagnostic and therapeutic strategies against hepatocellular carcinoma is of paramount importance. Solute carrier family 6 member 8 (SLC6A8) encodes the solute carrier family 6-8 to transport creatine into cells in a Na+ and Cl-- dependent manner. SLC6A8 deficiency is characterized by intellectual disabilities, loss of speech, and behavioral abnormalities. Of concern, the association of SLC6A8 with hepatocellular carcinoma remains elusive. In this study, we revealed that SLC6A8 knockdown significantly induced apoptosis and suppressed the migration and invasion of Hep3B and Huh-7 cells. These findings depicted the vital role of SLC6A8 in the initiation and progression of human hepatocellular carcinoma.

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