scholarly journals 24-Dehydrocholesterol Reductase alleviates oxidative damage-induced apoptosis in alveolar epithelial cells via regulating Phosphatidylinositol-3-Kinase/Protein Kinase B activation

Bioengineered ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 155-163
Author(s):  
Ming Yao ◽  
Feng Li ◽  
Liang Xu ◽  
Li Ma ◽  
Shutong Zhang
Keyword(s):  
Protein Kinase ◽  
Epithelial Cells ◽  
Oxidative Damage ◽  
Protein Kinase B ◽  
Alveolar Epithelial Cells ◽  
Phosphatidylinositol 3 Kinase ◽  
Alveolar Epithelial ◽  
Induced Apoptosis ◽  
Phosphatidylinositol 3

scholarly journals Cannabinoids Protect Astrocytes from Ceramide-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway

2002 ◽  
Vol 277 (39) ◽  
pp. 36527-36533 ◽  
Author(s):  
Teresa Gómez del Pulgar ◽  
Marı́a L. de Ceballos ◽  
Manuel Guzmán ◽  
Guillermo Velasco
Keyword(s):  
Protein Kinase ◽  
Protein Kinase B ◽  
Phosphatidylinositol 3 Kinase ◽  
Induced Apoptosis ◽  
Phosphatidylinositol 3

scholarly journals CTLA-4 Activation of Phosphatidylinositol 3-Kinase (PI 3-K) and Protein Kinase B (PKB/AKT) Sustains T-Cell Anergy without Cell Death

PLoS ONE ◽  
2008 ◽  
Vol 3 (12) ◽  
pp. e3842 ◽  
Author(s):  
Helga Schneider ◽  
Elke Valk ◽  
Rufina Leung ◽  
Christopher E. Rudd
Keyword(s):  
Cell Death ◽  
T Cell ◽  
Protein Kinase ◽  
Protein Kinase B ◽  
Phosphatidylinositol 3 Kinase ◽  
T Cell Anergy ◽  
Cell Anergy ◽  
Phosphatidylinositol 3

scholarly journals Activation of the Phosphatidylinositol 3-Kinase-Akt/Protein Kinase B Signaling Pathway in Arachidonic Acid-stimulated Human Myeloid and Endothelial Cells

2001 ◽  
Vol 276 (29) ◽  
pp. 27246-27255 ◽  
Author(s):  
Charles S. T. Hii ◽  
Nahid Moghadammi ◽  
Andrew Dunbar ◽  
Antonio Ferrante
Keyword(s):  
Endothelial Cells ◽  
Arachidonic Acid ◽  
Protein Kinase ◽  
Signaling Pathway ◽  
Protein Kinase B ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3

scholarly journals Abrogation of ER stress-induced apoptosis of alveolar epithelial cells by angiotensin 1–7

2013 ◽  
Vol 305 (1) ◽  
pp. L33-L41 ◽  
Author(s):  
Bruce D. Uhal ◽  
Hang Nguyen ◽  
MyTrang Dang ◽  
Indiwari Gopallawa ◽  
Jing Jiang ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Er Stress ◽  
Cathepsin D ◽  
Primary Cultures ◽  
A549 Cells ◽  
Surfactant Protein ◽  
Alveolar Epithelial Cells ◽  
Alveolar Epithelial ◽  
Induced Apoptosis ◽  
Jnk Activation

Earlier work showed that apoptosis of alveolar epithelial cells (AECs) in response to endogenous or xenobiotic factors is regulated by autocrine generation of angiotensin (ANG) II and its counterregulatory peptide ANG1–7. Mutations in surfactant protein C (SP-C) induce endoplasmic reticulum (ER) stress and apoptosis in AECs and cause lung fibrosis. This study tested the hypothesis that ER stress-induced apoptosis of AECs might also be regulated by the autocrine ANGII/ANG1–7 system of AECs. ER stress was induced in A549 cells or primary cultures of human AECs with the proteasome inhibitor MG132 or the SP-C BRICHOS domain mutant G100S. ER stress activated the ANGII-generating enzyme cathepsin D and simultaneously decreased the ANGII-degrading enzyme ACE-2, which normally generates the antiapoptotic peptide ANG1–7. TAPI-2, an inhibitor of ADAM17/TACE, significantly reduced both the activation of cathepsin D and the loss of ACE-2. Apoptosis of AECs induced by ER stress was measured by assays of mitochondrial function, JNK activation, caspase activation, and nuclear fragmentation. Apoptosis induced by either MG132 or the SP-C BRICHOS mutant G100S was significantly inhibited by the ANG receptor blocker saralasin and was completely abrogated by ANG1–7. Inhibition by ANG1–7 was blocked by the specific mas antagonist A779. These data show that ER stress-induced apoptosis is mediated by the autocrine ANGII/ANG1–7 system in human AECs and demonstrate effective blockade of SP-C mutation-induced apoptosis by ANG1–7. They also suggest that therapeutic strategies aimed at administering ANG1–7 or stimulating ACE-2 may hold potential for the management of ER stress-induced fibrotic lung disorders.

MicroRNA-31 regulating apoptosis by mediating the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in treatment of spinal cord injury

2019 ◽  
Vol 41 (8) ◽  
pp. 649-661 ◽  
Author(s):  
Yali Wang ◽  
Yitong Yuan ◽  
Yuantao Gao ◽  
Xiao Li ◽  
Feng Tian ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Protein Kinase ◽  
Signaling Pathway ◽  
Protein Kinase B ◽  
Phosphatidylinositol 3 Kinase ◽  
Cord Injury ◽  
Phosphatidylinositol 3

Implication of the Phosphatidylinositol-3 Kinase/Protein Kinase B Signaling Pathway in the Neuroprotective Effect of Estradiol in the Striatum of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mice

2006 ◽  
Vol 69 (4) ◽  
pp. 1492-1498 ◽  
Author(s):  
Myreille D'Astous ◽  
Pablo Mendez ◽  
Marc Morissette ◽  
Luis Miguel Garcia-Segura ◽  
Thérèse Di Paolo
Keyword(s):  
Protein Kinase ◽  
Signaling Pathway ◽  
Protein Kinase B ◽  
Neuroprotective Effect ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3
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