This chapter describes evidence-based strategies found to most effectively maximize the Return On Investment (ROI) of physicians' formal leadership training programs. Recognizing that no two prospective physician leaders are exactly the same, formal leadership training programs cannot be most effective if these do not allow for organizational and situational differences as well as critical differences among physicians' demonstrated personalities and leadership styles. When selecting prospective physician leaders, the authors advocate for an individualized process which requires “Diagnosis Before Treatment,” “Three Dimensional Screening,” and the application of “More Effective Alternative Strategies” in order to avoid committing the “12 Deadly Sins.”