Stem cell and its derivatives as drug delivery vehicles: an effective new strategy of drug delivery system

Liposome–microbubble conjugates are considered as better targeted drug delivery vehicles compared to microbubbles alone. The microbubble in the integrated drug delivery system delivers the drug intracellularly on the target, whereas the liposome component allows loading of high drug dose and extravasation through leaky vasculature. In this work, a new high yielding microbubble production method was used to prepare microbubbles for formulation of the liposome-conjugated drug delivery system. In formulation process, the prepared liposome of 200 nm diameter was attached to the microbubble surface using the avidin–biotin interaction. The analysis of the confocal scanning laser microscope images showed that approximately 8 × 108 microbubbles per millilitre (range: 2–7 μm, mean size 5 ± 0.5 μm) can be efficiently conjugated to the liposomes. The method of conjugation was found to be effective in attaching liposome to microbubbles.

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Development of a microdevice-based human mesenchymal stem cell-mediated drug delivery system

Biomaterials Science ◽

10.1039/c8bm01634h ◽

2019 ◽

Vol 7 (6) ◽

pp. 2348-2357 ◽

Cited By ~ 6

Author(s):

Junfei Xia ◽

Ang-Chen Tsai ◽

Wenhao Cheng ◽

Xuegang Yuan ◽

Teng Ma ◽

...

Keyword(s):

Drug Delivery ◽

Stem Cell ◽

Mesenchymal Stem Cell ◽

Drug Delivery System ◽

Delivery System ◽

Drug Delivery Systems ◽

Human Mesenchymal Stem Cell ◽

Living Cells ◽

Controlled Delivery ◽

System P

Cell-mediated drug delivery systems utilize living cells as vehicles to achieve controlled delivery of drugs.

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Efficient drug delivery system for bone repair by tuning the surface of hydroxyapatite particles

RSC Advances ◽

10.1039/c6ra24551j ◽

2016 ◽

Vol 6 (107) ◽

pp. 104969-104978 ◽

Cited By ~ 12

Author(s):

Sobia Tabassum ◽

Saba Zahid ◽

Faiza Zarif ◽

Mazhar Amjad Gilani ◽

Faisal Manzoor ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Surface Properties ◽

Functional Groups ◽

Bone Repair ◽

Precipitation Method ◽

Drug Delivery Vehicles ◽

Delivery Vehicles ◽

Co Precipitation

Efficient drug delivery vehicles, hydroxyapatite modified by carboxylic acids, were prepared by an in situ co-precipitation method. The presence of functional groups and subsequent surface properties of modified HA improved ibuprofen loading and release efficiency.

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Drug delivery system. A new strategy for targeting enzymes and bioactive peptides.

Drug Delivery System ◽

10.2745/dds.4.264 ◽

1989 ◽

Vol 4 (4) ◽

pp. 264-269

Author(s):

Masayasu Inoue ◽

Nobukazu Watanabe

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Bioactive Peptides ◽

System A ◽

New Strategy

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Chitosan for biomedical applications, promising antidiabetic drug delivery system, and new diabetes mellitus treatment based on stem cell

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2021.08.154 ◽

2021 ◽

Author(s):

Sarah I. Othman ◽

Asma M. Alturki ◽

Gasem Mohammad Abu-Taweel ◽

Naif Ghazi Altoom ◽

Ahmed A. Allam ◽

...

Keyword(s):

Diabetes Mellitus ◽

Drug Delivery ◽

Stem Cell ◽

Drug Delivery System ◽

Delivery System ◽

Biomedical Applications ◽

Antidiabetic Drug ◽

Diabetes Mellitus Treatment

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Recent Advances in Drug Delivery System for Bioactive Glycosides from Traditional Chinese Medicine

The American Journal of Chinese Medicine ◽

10.1142/s0192415x18500908 ◽

2018 ◽

Vol 46 (08) ◽

pp. 1791-1824 ◽

Cited By ~ 6

Author(s):

Lei Li ◽

Yi Feng ◽

Yanlong Hong ◽

Xiao Lin ◽

Lan Shen

Keyword(s):

Drug Delivery ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Drug Delivery System ◽

Delivery System ◽

Therapeutic Efficacy ◽

Design Strategies ◽

Active Ingredients ◽

Recent Advances ◽

Delivery Vehicles

Traditional Chinese Medicine (TCM) has been used in China for thousands of years for the prevention and treatment of various diseases. The materials that exert a therapeutic effect are called the active ingredients. The bioactive glycosides are important active ingredients from TCM that can make significant contributions to treating diseases. Because of the possibilities of various clinical applications, the properties and administration of these bioactive glycosides deserve further investigation. Their promising treatment effects, however, are hindered by their poor solubility, poor stability and rapid elimination. Therefore, it is necessary that we improve the therapeutic efficacy of bioactive glycosides by overcoming these problems. Meanwhile, some practical design strategies and novel drug delivery vehicles based on drug delivery systems provide favorable support in clinical practice for these active ingredients. This review summarizes diverse pharmacological activities of bioactive glycosides and focuses on recent advances in delivery system for these active constitutes; in particular, some glycol glycosides can effectively cure intractable diseases through targeted drug delivery. This review elucidates some design strategies for drug delivery system that are mainly based on two methods (avoiding physical barriers by changing dosage forms and enhancing the ability to bind to receptors or proteins after administration) and indicate the current challenges during the combination of delivery vehicles and these glycosides in hopes of promoting the process of receiving ideal therapeutic efficacy of them in future studies.

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Targeted drug delivery vehicles mediated by nanocarriers and aptamers for posterior eye disease therapeutics: barriers, recent advances and potential opportunities

Nanotechnology ◽

10.1088/1361-6528/ac46d5 ◽

2021 ◽

Author(s):

Tingting Zhang ◽

Xin Jin ◽

Nan Zhang ◽

Xinyi Jiao ◽

Yuanyuan Ma ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Targeted Drug Delivery ◽

Posterior Segment ◽

Drug Delivery Vehicles ◽

Effective Strategies ◽

Combined Application ◽

Targeted Drug ◽

Ophthalmic Therapy

Abstract Nanomedicine and aptamer have excellent potential in giving play to passive and active targeting respectively, which are considered to be effective strategies in the retro-ocular drug delivery system. The presence of closely adjoined tissue structures in the eye makes it difficult to administer the drug in the posterior segment of the eye. The application of nanomedicine could represent a new avenue for the treatment, since it could improve penetration, achieve targeted release, and improve bioavailability. Additionally, a novel type of targeted molecule aptamer with identical objective was proposed. As an emerging molecule, aptamer shows the advantages of penetration, non-toxicity, and high biocompatibility, which make it suitable for ocular drug administration. The purpose of this paper is to summarize the recent studies on the effectiveness of nanoparticles as a drug delivery to the posterior segment of the eye. This paper also creatively looks forward to the possibility of the combined application of nanocarriers and aptamers as a new method of targeted drug delivery system in the field of post-ophthalmic therapy.

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