Delayed diffusion-weighted MR abnormality in a patient with an extensive acute cerebral hypoxic injury: A case report

2003 ◽  
Vol 44 (3) ◽  
pp. 343-346
Author(s):  
J. K. Hald ◽  
J. A. Brunberg ◽  
A. B. Dublin ◽  
S. L. Wootton-Gorges
Keyword(s):  
Case Report ◽  
Mr Imaging ◽  
Suicide Attempt ◽  
Cerebral Infarction ◽  
Hypoxic Injury ◽  
Diffusion Weighted ◽  
Hypoxic Brain Injury ◽  
Hypoxic Brain ◽  
Anoxic Injury

Diffusion-weighted (DW) MR imaging usually identifies acute cerebral infarction injury in symptomatic patients. We report a patient with severe hypoxic brain injury following suicide attempt by hanging, but with normal DW MR imaging 5–6 h after the event. Follow-up DW MR imaging 3 days after the event, and subsequent autopsy, revealed extensive cerebral anoxic injury.

Complementary roles of bone scintigraphy and MR imaging in the detection and long-term follow-up of primary non-Hodgkin’s bone lymphoma in a child-case report

2014 ◽  
Vol 44 (6) ◽  
pp. 863-868 ◽  
Author(s):  
Vlajković Marina ◽  
Rajić Milena ◽  
Petronijević Vesna ◽  
Petrović Slađana ◽  
Artiko Vera
Keyword(s):  
Case Report ◽  
Mr Imaging ◽  
Bone Scintigraphy ◽  
Long Term Follow Up ◽  
Bone Lymphoma

The adjunctive value of diffusion weighted imaging in diagnosis and follow up of uterovaginal diffuse B-cell lymphoma: A case report and literature review.

2021 ◽  
Vol 17 ◽  
Author(s):  
Gehad A. Saleh ◽  
Reham Alghandour ◽  
Eman Y Rashad ◽  
Ahmed M Tawfik ◽  
Ali H. Elmokadem
Keyword(s):  
Case Report ◽  
B Cell ◽  
Diffusion Weighted Imaging ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Diagnostic Methods ◽  
Pelvic Mri ◽  
Diffusion Weighted ◽  
Large B Cell

Background: Lymphoma of the female gynecologic tract is extremely rare. Typically, lymphoma is managed non surgically unlike other non-lymphomatous malignant tumors raising the importance to differentiate between both entities. Case report: We describe the magnetic resonance imaging (MRI) features of a case of uterovaginal diffuse large B-cell lymphoma in a 50-year-old postmenopausal woman emphasizing Diffusion-Weighted Imaging (DWI) as a diagnostic and follow up tool. We reviewed the literature regarding the diagnostic methods for female genital lymphoma. Forty-five cases including our patient were reviewed with age range from 22 to 85 years. Vaginal bleeding was the most common presentation. The diagnosis was established by Papanicolaou smear, cervical biopsy (25/45), endometrial biopsy (6/45), vaginal biopsy (2/45), pelvic mass biopsy (2/45), iliac LN biopsy (1/45) and surgical diagnosis (8/45). Diffuse large B-cell lymphomas (DLBCL) constitute the vast majority of the cases (82%). The uterine cervix was involved at diagnosis in the majority of these cases (68%) while uterine body (42%) and vagina (28%) were less involved. Pelvic lymphadenopathy was found in 15 cases while extra genital lymphomatous infiltration in 13 cases. Sonographic findings were nonspecific while CT provided excellent data about extra-genital involvement. Thirteen cases underwent pelvic MRI that displayed superior detection of disease extension and parametric involvement. Diffusion restriction was reported only in one case without quantitative analysis of ADC map. Conclusion: MRI shows unique features that help to differentiate uterovaginal lymphoma from the much more common carcinomas and discriminate post-operative changes from tumor recurrence. It exhibits a marked restricted diffusion pattern with lower ADC values than carcinomas and post-operative changes.

scholarly journals Comparison of 3T diffusion-weighted MRI and 18F-FDG PET/CT in musculoskeletal tumours: quantitative analysis of apparent diffusion coefficients and standardized uptake values

2019 ◽  
Vol 92 (1102) ◽  
pp. 20181051 ◽  
Author(s):  
So-Yeon Lee ◽  
Won-Hee Jee ◽  
Ie Ryung Yoo ◽  
Joon-Yong Jung ◽  
Soo-A Im ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Fdg Pet ◽  
Inverse Correlation ◽  
Diffusion Weighted ◽  
Pet Ct ◽  
Apparent Diffusion ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
3T Mr

Objective: To determine whether the apparent diffusion coefficient (ADC) on 3T MR imaging including diffusion-weighted MR imaging (DWI) correlate with the standardized uptake value (SUV) on 18F-FDG PET/CT in musculoskeletal tumours. Methods: This retrospective cohort study included 57 patients (36 males, 21 females, mean age 54 years, range 12–90 years) with pathologically confirmed soft tissue (n = 32) and bone (n = 25) tumours who underwent 3T MR imaging including DWI and whole-body 18F-FDG PET/CT before treatment. 14 patients had follow-up MR imaging and 18F-FDG PET/CT after treatment. The minimum (ADCmin) and mean (ADCmean) ADCs of musculoskeletal tumour, ADC of normal skeletal muscle (ADCmus), SUVmax and SUVmean of musculoskeletal tumour were obtained. Correlation between ADCs and SUVs was assessed using Pearson correlation coefficients (r). ADCmin and SUVmax were compared between pretreatment and posttreatment by t-test. Results: There was inverse correlation between SUVmax and the ratio ADCmin/ADCmus (r = - 0.505 to - 0.495, p ≤ 0.001) and between SUVmean and the ratio ADCmean/ADCmus (r = - 0.501 to - 0.493, p = 0.001). After treatment ADC was significantly increased whereas SUV was significantly decreased (p = 0.001). There was significant correlation in percent change between the initial and follow-up values of ADCmin and SUVmax (r = 0.750 to 0.773, p ≤ 0.005). The ADCmin was increased by 163% and SUVmax was decreased by 61% in 11 patients with treatment response. Conclusion: ADC at 3T MR DWI and SUV at 18F-FDG PET/CT have an inverse correlation in musculoskeletal tumours. Advances in knowledge: Our study showed that ADC at 3T DWI and SUV at 18F-FDG PET/CT had an inverse correlation in musculoskeletal tumours.

Hypoxic Brain Injury Following Heroin Overdose

2009 ◽  
Vol 10 (2) ◽  
pp. 169-179 ◽  
Author(s):  
Patricia O'Brien ◽  
Jenny Todd
Keyword(s):  
Brain Injury ◽  
Brain Injuries ◽  
Community Integration ◽  
Care Facility ◽  
Functional Independence ◽  
Rehabilitation Centre ◽  
Heroin Overdose ◽  
Hypoxic Brain Injury ◽  
Hypoxic Brain

AbstractHypoxic brain injury is an under-recognised consequence of heroin overdose. This article documents the disability experienced by 10 people with hypoxic brain injuries following heroin overdose who presented in the 2-year period July 1997 to June 1999 at the Royal Talbot Rehabilitation Centre, a brain injury rehabilitation facility in Melbourne, Australia. Medical histories of these clients were reviewed and follow-up interviews were conducted between 2 and 4 years postinjury. Measures included the Functional Independence Measure (FIM) and the Community Integration Questionnaire (CIQ). The results showed that there were significant and enduring consequences for most of the 10 participants. At follow-up two participants had died from subsequent overdose, three required support to live in the community and one lived in an aged care facility. Only one participant was able to return to work. Cognitive problems were present in most of the group and problem solving and social interaction difficulties were the most commonly recorded problems. Three cases are described in detail to highlight some of the significant issues identified in this sample. Implications for the rehabilitation of people with brain injury following heroin overdose are discussed.

Diffusion-weighted imaging lesion growth occurs despite recanalization in acute ischemic stroke: Implications for future treatment trials

2018 ◽  
Vol 14 (3) ◽  
pp. 257-264 ◽  
Author(s):  
Rani G Sah ◽  
Christopher D d’Esterre ◽  
Michael D Hill ◽  
Moiz Hafeez ◽  
Sana Tariq ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cerebral Infarction ◽  
Effect Size ◽  
Diffusion Weighted Imaging ◽  
Arterial Occlusion ◽  
National Institutes Of Health ◽  
Stroke Therapy ◽  
Diffusion Weighted ◽  
Lesion Growth

Background A proportion of patients presenting with acute small ischemic strokes have poor functional outcomes, even following rapid recanalization treatment. Aims Infarct growth may occur even after successful recanalization and could represent an appropriate endpoint for future stroke therapy trials. Methods Magnetic resonance diffusion-weighted imaging lesion volumes were obtained at 5 h (initial posttreatment) and 24 h (follow-up) after acute stroke treatment for n = 33 in ischemic stroke patients. Sample sizes per arm (90% power, 30% effect size) for diffusion-weighted imaging lesion growth between initial and 24 h, early change in the National Institutes of Health Stroke Scale between pre- and 24 h, National Institutes of Health Stroke Scale at 24 h, and diffusion-weighted imaging lesion volume at 24 h were estimated to power a placebo-controlled stroke therapy trial. Results For patients with poor recanalization (modified thrombolysis in cerebral infarction <2 a; modified arterial occlusion lesion = 0–2) (n = 11), the median diffusion-weighted imaging lesion growth was 8.1 (interquartile range: 4.5, 22.4) ml and with good recanalization (modified thrombolysis in cerebral infarction =2 b or 3; modified arterial occlusion lesion = 3) (n = 22), the median diffusion-weighted imaging lesion growth was 10.0 (interquartile range: 6.0, 28.2) ml ( P = 0.749). When considering a 30% effect size, the sample size required per arm to achieve significance in an acute stroke study would be: (1) N = 49 for the diffusion-weighted imaging lesion growth between initial posttreatment and follow-up time points, (2) N = 65 for the change in the National Institutes of Health Stroke Scale between admission and 24 h, (3) N = 259 for the National Institutes of Health Stroke Scale at 24 h, and (4) N = 256 for diffusion-weighted imaging volume at 24 h. Conclusion Despite best efforts to recanalize the ischemic brain, early diffusion-weighted imaging lesion growth still occurs. Treatment trials in stroke should consider early diffusion-weighted imaging lesion growth as a surrogate outcome measure to significantly reduce sample sizes.

scholarly journals Reversible hypoxic brain injury: the penumbra conundrum of Grinker

2019 ◽  
Vol 12 (4) ◽  
pp. e228670
Author(s):  
Shiva Balan ◽  
Kartik Gupta ◽  
Parthiban Balasundaram ◽  
Ranveer Jadon
Keyword(s):  
Mechanical Ventilation ◽  
Magnetic Resonance ◽  
Daily Living ◽  
Community Acquired Pneumonia ◽  
Hypoxic Brain Injury ◽  
Hypoxic Brain ◽  
History Of ◽  
Magnetic Resonance Brain Imaging

A female patient, aged 61 years, presented to us with a 3-day history of fever and altered sensorium. She was discharged from another hospital 1 week back where she was admitted for community-acquired pneumonia. She was put on mechanical ventilation for threatened airway and her magnetic resonance brain imaging showed evidence of delayed posthypoxic leucoencephalopathy, also known as Grinker’s myelinopathy. She was discharged 1 month later, on room air with a tracheostomy tube in situ. On follow-up after 5 months, she was ambulating with support and carried out activities of daily living independently.

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