scholarly journals Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells.

1985 ◽  
Vol 100 (1) ◽  
pp. 327-332 ◽  
Author(s):  
K Boller ◽  
D Vestweber ◽  
R Kemler
Keyword(s):  
Cell Adhesion ◽  
Epithelial Cells ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Intestinal Epithelial Cells ◽  
Rabbit Antiserum ◽  
Preimplantation Embryos ◽  
Intestinal Epithelial ◽  
Electron Microscopic ◽  
A Cell

Uvomorulin is a cell-adhesion molecule implicated in the compaction process of mouse preimplantation embryos and the aggregation of embryonal carcinoma cells. A rabbit antiserum against purified uvomorulin also reacts with epithelial cells of various adult tissues. In this study, we investigated the localization of uvomorulin on adult intestinal epithelial cells using electron microscopic analyses. Uvomorulin was shown to exhibit a highly restricted localization in the intermediate junctions of these cells. The results are discussed with respect to a possible adhesive function of uvomorulin on intestinal epithelial cells.

scholarly journals JAM4, a Junctional Cell Adhesion Molecule Interacting with a Tight Junction Protein, MAGI-1

2003 ◽  
Vol 23 (12) ◽  
pp. 4267-4282 ◽  
Author(s):  
Susumu Hirabayashi ◽  
Makiko Tajima ◽  
Ikuko Yao ◽  
Wataru Nishimura ◽  
Hiroki Mori ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Epithelial Cells ◽  
Tight Junctions ◽  
Adhesion Molecule ◽  
Intestinal Epithelial Cells ◽  
Cell Junctions ◽  
Intestinal Epithelial ◽  
Cell Contacts ◽  
L Cells ◽  
Junction Protein

ABSTRACT MAGI-1 is a membrane-associated guanylate kinase protein at tight junctions in epithelial cells. It interacts with various molecules and functions as a scaffold protein at cell junctions. We report here a novel MAGI-1-binding protein that we named junctional adhesion molecule 4 (JAM4). JAM4 belongs to an immunoglobulin protein family. JAM4 was colocalized with ZO-1 in kidney glomeruli and in intestinal epithelial cells. Biochemical in vitro studies revealed that JAM4 bound to MAGI-1 but not to ZO-1, whereas JAM1 did not bind to MAGI-1. JAM4 and MAGI-1 interacted with each other and formed clusters in COS-7 cells when coexpressed. JAM4 mediated calcium-independent homophilic adhesion and was accumulated at cell-cell contacts when expressed in L cells. MAGI-1, ZO-1, and occludin were recruited to JAM4-based cell contacts. JAM4 also reduced the permeability of CHO cell monolayers. MAGI-1 strengthened JAM4-mediated cell adhesion in L cells and sealing effects in CHO cells. These findings suggest that JAM4 together with MAGI-1 provides an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells.

Function and Histopathology of a Cell Adhesion Molecule TSLC1 in Cancer

2011 ◽  
Vol 29 (2) ◽  
pp. 107-112 ◽  
Author(s):  
Qi-Lian Liang ◽  
Guo-Qiang Chen ◽  
Zhou-Yu Li ◽  
Bi-Rong Wang
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
A Cell

scholarly journals Human Blastocysts and Endometrial Epithelial Cells Express Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166)

2003 ◽  
Vol 88 (7) ◽  
pp. 3437-3443 ◽  
Author(s):  
Hiroshi Fujiwara ◽  
Keiji Tatsumi ◽  
Kenzo Kosaka ◽  
Yukiyasu Sato ◽  
Toshihiro Higuchi ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Epithelial Cells ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Endometrial Epithelial Cells

Design of a Calcium-Binding Protein with Desired Structure in a Cell Adhesion Molecule

2005 ◽  
Vol 127 (7) ◽  
pp. 2085-2093 ◽  
Author(s):  
Wei Yang ◽  
Anna L. Wilkins ◽  
Yiming Ye ◽  
Zhi-ren Liu ◽  
Shun-yi Li ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Calcium Binding ◽  
Cell Adhesion Molecule ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
A Cell

scholarly journals Potential role of SC1, a cell adhesion molecule, in mammary gland tumors

2008 ◽  
Author(s):  
Kenji Hagimori ◽  
Hidenori Kato ◽  
Keiko Fukuda ◽  
Masaharu Kikuta ◽  
Yasuhiro Tsukamoto ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Mammary Gland ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Potential Role ◽  
Mammary Gland Tumors ◽  
A Cell
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