scholarly journals LOCALIZATION OF THE SITES OF γ-AMINOBUTYRIC ACID (GABA) UPTAKE IN LOBSTER NERVE-MUSCLE PREPARATIONS

1971 ◽  
Vol 49 (1) ◽  
pp. 75-89 ◽  
Author(s):  
Paula M. Orkand ◽  
Edward A. Kravitz
Keyword(s):  
Amino Acid ◽  
Connective Tissue ◽  
Electron Micrographs ◽  
Aminobutyric Acid ◽  
Gaba Uptake ◽  
Tissue Cell ◽  
Connective Tissue Cell ◽  
Cell Cytoplasm ◽  
Nerve Muscle

The principal sites of γ-aminobutyric acid (GABA) uptake in lobster nerve-muscle preparations have been determined with radioautographic techniques after binding of the amino acid to proteins by aldehyde fixation. Semiquantitative studies showed that about 30% of the radioactive GABA taken into the tissue was bound to protein by fixation. Both light and electron micrographs showed dense accumulations of label over Schwann and connective tissue cell cytoplasm; muscle was lightly labeled, but axons and terminals were almost devoid of label. The possible role of Schwann and connective tissue cells in the inactivation of GABA released from inhibitory axons is discussed.

Evaluation of Connective Tissue Cell Responses to Orthopaedic Implant Materials

1990 ◽  
Vol 24 (1) ◽  
pp. 77-81 ◽  
Author(s):  
S. R. Goldring ◽  
M. S. Flannery ◽  
K. K. Petrison ◽  
A. E. Evins ◽  
M. J. Jasty
Keyword(s):  
Connective Tissue ◽  
Tissue Cell ◽  
Orthopaedic Implant ◽  
Connective Tissue Cell ◽  
Implant Materials ◽  
Cell Responses

Brain amino acid concentrations during diving and acid-base stress in turtles

1985 ◽  
Vol 58 (6) ◽  
pp. 1751-1754 ◽  
Author(s):  
B. M. Hitzig ◽  
M. P. Kneussl ◽  
V. Shih ◽  
R. D. Brandstetter ◽  
H. Kazemi
Keyword(s):  
Amino Acid ◽  
Aminobutyric Acid ◽  
Breath Hold ◽  
Gamma Aminobutyric Acid ◽  
Amino Acid Neurotransmitters ◽  
Acid Base ◽  
Ventilatory Drive ◽  
Amino Acid Concentrations ◽  
Brain Amino Acid

To assess the role of brain amino acid neurotransmitters in the breath hold of diving animals, concentrations of free amino acids present in the brains of turtles immediately after 2 h of apneic diving (at 20 degrees C) were measured. Additionally, the same measurements were performed on four other groups of animals subjected to 2 h of hypercapnia (8% CO2 in air), anoxia (N2 breathing), anoxia plus hypercapnia (8% CO2–92% N2), or air breathing (control). Significant changes in the concentrations of the inhibitory amino acid neurotransmitters known to affect respiration [gamma-aminobutyric acid (GABA) and taurine] were seen. GABA increased significantly in those animals subjected to anoxia, whereas taurine decreased significantly in the diving animals and increased significantly in those subjected to anoxia plus hypercapnia. These results suggest that the attenuated central ventilatory drive during diving in these animals may be related to alterations in brain concentrations of GABA and taurine.

scholarly journals THE CELLULAR REACTIONS TO ACETONE-SOLUBLE FAT FROM MYCOBACTERIA AND STREPTOCOCCI

1935 ◽  
Vol 61 (6) ◽  
pp. 771-782 ◽  
Author(s):  
Kenneth C. Smithburn ◽  
Florence R. Sabin
Keyword(s):  
Connective Tissue ◽  
Tissue Cell ◽  
Connective Tissue Cell ◽  
Cellular Reaction ◽  
Alkali Neutralization

1. The acetone-soluble fat of tubercle bacilli produces a profound cellular reaction when injected into normal animals. The reaction involves every type of connective tissue cell. Hemorrhage, formation of adhesions and of tubercular tissue occur. The extent of the reaction is roughly proportional to the amount of material injected. 2. The reaction induced by the lipoid is much less extensive and much simpler when the material is neutralized with alkali. Neutralization of the acetone-soluble fat, or of phthioic acid, does not diminish the tuberculogenic property. 3. Acetone-soluble fat from streptococci is likewise extremely irritating but does not produce tubercular tissue.

Stimulation of connective tissue cell growth by substance P and substance K

Nature ◽  
1985 ◽  
Vol 315 (6014) ◽  
pp. 61-63 ◽  
Author(s):  
Jan Nilsson ◽  
Anne M. von Euler ◽  
Carl-Johan Dalsgaard
Keyword(s):  
Cell Growth ◽  
Substance P ◽  
Connective Tissue ◽  
Tissue Cell ◽  
Connective Tissue Cell ◽  
Substance K ◽  
Stimulation Of
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