scholarly journals CROSSING OVER BETWEEN GENES IN THE IMMUNOGLOBULIN HEAVY CHAIN LINKAGE GROUP OF THE MOUSE

1969 ◽  
Vol 130 (3) ◽  
pp. 519-541 ◽  
Author(s):  
Rose Lieberman ◽  
Michael Potter
Keyword(s):  
Linkage Group ◽  
Heavy Chain ◽  
Inbred Mice ◽  
Wild Mouse ◽  
Immunoglobulin Heavy Chain ◽  
Inbred Strains ◽  
Linkage Groups ◽  
Wild Mice ◽  
Immunoglobulin Heavy Chain Genes ◽  
Papain Digestion

Immunoglobulin heavy chain genes were found in wild mice (Mus musculus) that could best be explained as recombinants of immunoglobulin genotypes. In wild mice from Kitty Hawk, N. C., two new heavy chain linkage groups, G3,5,7,8H9,11FfA- and G3,5,8H9,11FfA-, were found, each of which genetically controls both the 3 and 5 distinct immunoglobulin determinants. In inbred strains the 3 and 5 determinants are found independently. The new heavy chain allotype G3,5,7,8H9,11FfA- probably arose from a homologous (intragenic) cross-over between G3,8H9,11FfA- and G5,7,8H9,11FfA14 heavy chain linkage groups. It was suggested that genes controlling G3,8G5,7,8, G3,5,8, and G3,5,7,8 are alleles. Another homozygous wild mouse (Kyushu, Japan) showed a new heavy chain allotype, 2G1,6,7,8H9,16FsA15. The 2 and G1,6,7,8 determinants are also separated in inbred strains. The 2 determinant in inbred mice is not on the γF, γH, or γA heavy chain and is probably on a γG or γG-like immunoglobulin heavy chain. Papain digestion of serum from the Kyushu mouse showed two electrophoretically different Fc fragments, one carrying the G1,6,7,8 and the other the 2 determinant. The new heavy chain allotype, 2G1,6,7,8H9,16FsA15, of the Kyushu wild mouse probably arose from a nonhomologous (unequal) cross over between 2G-H9,16FsA15 and G1,6,7,8H9,11FfA12,13,14 heavy chain linkage groups. The linkage group of the Kyushu wild mouse has at least five heavy chain genes, while that of the inbred mice has four.

scholarly journals SERUM CONCENTRATIONS AND ALLOTYPES OF IMMUNO-GLOBULINS IN TWO LINES OF MICE GENETICALLY SELECTED FOR "HIGH" OR "LOW" ANTIBODY SYNTHESIS

1970 ◽  
Vol 132 (4) ◽  
pp. 752-764 ◽  
Author(s):  
Guido Biozzi ◽  
Richard Asofsky ◽  
Rose Lieberman ◽  
Claude Stiffel ◽  
Denise Mouton ◽  
...  
Keyword(s):  
Heavy Chain ◽  
Inbred Mice ◽  
Serum Levels ◽  
Inbred Strains ◽  
The United States ◽  
Linkage Groups ◽  
Wild Mice ◽  
Recombinant Type ◽  
Low Responder ◽  
Immuno Globulins

Random-bred Swiss mice were selectively bred for 16 generations; selection was based on their agglutinin response to sheep and pigeon erythrocytes to produce a high and a low responder line. The serum levels of individual immunoglobulins differed significantly in these two lines before immunization. The differences in the levels of immunoglobulins were much more marked after immunization with pigeon or sheep erythrocytes. Greater differences between the two lines were noted in IgM and IgG levels than in IgA. Another remarkable finding was the presence of different immunoglobulin phenotypes in the two lines. The high responders were homozygous or heterozygous for heavy-chain linkage groups found separately in the prototype BALB/c and C57BL inbred strains. The low responders were homozygous for a heavy-chain linkage group not present in bred mice in the United States, but observed as a recombinant type among wild mice probably representing a crossover between the heavy-chain linkage groups of the prototype DBA/2 and NH inbred mice.

REPERTOIRE OF REARRANGED IMMUNOGLOBULIN HEAVY CHAIN GENES IN RUSSIAN PATIENTS WITH B-CELL LYMPHOPROLIFERATIVE DISEASES

2021 ◽  
Author(s):  
B.V. Biderman ◽  
E.B. Likold ◽  
S.Yu. Smirnova ◽  
E.A. Nikitin ◽  
D.A. Koroleva ◽  
...  
Keyword(s):  
B Cell ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Lymphoproliferative Diseases ◽  
Immunoglobulin Heavy Chain Genes

scholarly journals Somatic hypermutation of human immunoglobulin heavy chain genes: targeting of RGYW motifs on both DNA strands

1998 ◽  
Vol 28 (10) ◽  
pp. 3384-3396 ◽  
Author(s):  
Thomas Dörner ◽  
Sandra J. Foster ◽  
Nancy L. Farner ◽  
Peter E. Lipsky
Keyword(s):  
Heavy Chain ◽  
Somatic Hypermutation ◽  
Immunoglobulin Heavy Chain ◽  
Human Immunoglobulin ◽  
Dna Strands ◽  
Immunoglobulin Heavy Chain Genes

Immunoglobulin heavy chain genes of rabbit

1995 ◽  
pp. 289-314 ◽  
Author(s):  
Katherine L. Knight ◽  
Chainarong Tunyaplin
Keyword(s):  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Immunoglobulin Heavy Chain Genes

PCR amplification and high throughput sequencing of immunoglobulin heavy chain genes from formalin-fixed paraffin-embedded human biopsies

2013 ◽  
Vol 94 (1) ◽  
pp. 182-187 ◽  
Author(s):  
Hilla Tabibian-Keissar ◽  
Ginette Schibby ◽  
Miri Michaeli ◽  
Aviya Rakovsky-Shapira ◽  
Noemie Azogui-Rosenthal ◽  
...  
Keyword(s):  
High Throughput ◽  
Heavy Chain ◽  
High Throughput Sequencing ◽  
Pcr Amplification ◽  
Immunoglobulin Heavy Chain ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Immunoglobulin Heavy Chain Genes ◽  
Formalin Fixed

NO LINKAGE OR ASSOCIATION OF A VNTR MARKER IN THE JUNCTION REGION OF THE IMMUNOGLOBULIN HEAVY CHAIN GENES IN MULTIPLE SCLEROSIS

1997 ◽  
Vol 24 (4) ◽  
pp. 259-264 ◽  
Author(s):  
A. Ligers ◽  
B. He ◽  
A. Fogdell-Hahn ◽  
O. Olerup ◽  
J. Hillert
Keyword(s):  
Multiple Sclerosis ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Junction Region ◽  
Immunoglobulin Heavy Chain Genes

Presence of N regions in the clonotypic DJ rearrangements of the immunoglobulin heavy-chain genes indicates an exquisitely short latency in t(4;11)-positive infant acute lymphoblastic leukemia

Blood ◽  
2001 ◽  
Vol 98 (7) ◽  
pp. 2272-2274 ◽  
Author(s):  
Karin Fasching ◽  
Simon Panzer ◽  
Oskar A. Haas ◽  
Arndt Borkhardt ◽  
Rolf Marschalek ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Heavy Chain ◽  
Lymphoblastic Leukemia ◽  
Latency Period ◽  
Immunoglobulin Heavy Chain ◽  
In Utero ◽  
Cell Precursor ◽  
Developmentally Regulated ◽  
Igh Genes ◽  
Immunoglobulin Heavy Chain Genes

Childhood acute lymphoblastic leukemia (ALL) is frequently initiated in utero at a time of developmentally regulated insertion of N regions into the DJH rearrangements of immunoglobulin heavy-chain (IgH) genes. Here it is shown that N regions are present in the clonotypic DJH rearrangements in 11 of 12 infant ALLs with t(4;11). These data are compared with the 122 previously published DJH sequences and were found to have a pattern similar to that of ALL in children older than 3 years at diagnosis but were unlike that in children younger than 3 years who predominantly lack N regions. These findings, therefore, indicate that t(4;11)-positive infant ALL is initiated later in fetal development than most B-cell precursor ALL from children younger than 3 years and that they have a shorter latency period already in utero.

scholarly journals Detection of Clone-Specific Immunoglobulin Heavy Chain Genes in the Bone Marrow of B-cell-Lineage Lymphoma after Treatment

2004 ◽  
Vol 203 (3) ◽  
pp. 155-164 ◽  
Author(s):  
Atsushi Hoshino ◽  
Tadao Funato ◽  
Yasuhiko Munakata ◽  
Tomonori Ishii ◽  
Shori Abe ◽  
...  
Keyword(s):  
Bone Marrow ◽  
B Cell ◽  
Heavy Chain ◽  
Cell Lineage ◽  
Immunoglobulin Heavy Chain ◽  
Specific Immunoglobulin ◽  
Immunoglobulin Heavy Chain Genes
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