scholarly journals The Human Toll Signaling Pathway: Divergence of Nuclear Factor κB and JNK/SAPK Activation Upstream of Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6)

1998 ◽  
Vol 187 (12) ◽  
pp. 2097-2101 ◽  
Author(s):  
Marta Muzio ◽  
Gioacchino Natoli ◽  
Simona Saccani ◽  
Massimo Levrero ◽  
Alberto Mantovani

The human homologue of Drosophila Toll (hToll) is a recently cloned receptor of the interleukin 1 receptor (IL-1R) superfamily, and has been implicated in the activation of adaptive immunity. Signaling by hToll is shown to occur through sequential recruitment of the adapter molecule MyD88 and the IL-1R–associated kinase. Tumor necrosis factor receptor–activated factor 6 (TRAF6) and the nuclear factor κB (NF-κB)–inducing kinase (NIK) are both involved in subsequent steps of NF-κB activation. Conversely, a dominant negative version of TRAF6 failed to block hToll-induced activation of stress-activated protein kinase/c-Jun NH2-terminal kinases, thus suggesting an early divergence of the two pathways.

2001 ◽  
Vol 276 (19) ◽  
pp. 16399-16405 ◽  
Author(s):  
Hideo Yoshida ◽  
Naoya Kato ◽  
Yasushi Shiratori ◽  
Motoyuki Otsuka ◽  
Shin Maeda ◽  
...  

Hepatology ◽  
2000 ◽  
Vol 32 (6) ◽  
pp. 1272-1279 ◽  
Author(s):  
Masahito Nagaki ◽  
Takafumi Naiki ◽  
David A. Brenner ◽  
Yosuke Osawa ◽  
Motoaki Imose ◽  
...  

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