scholarly journals MODIFICATION OF THE PATHOGENICITY OF PSEUDORABIES VIRUS BY ANIMAL PASSAGE

1933 ◽  
Vol 57 (6) ◽  
pp. 925-931 ◽  
Author(s):  
Richard E. Shope
Keyword(s):  
Guinea Pig ◽  
Guinea Pigs ◽  
Pseudorabies Virus ◽  
Pig Brain ◽  
Two Factors ◽  
Cerebral Infection ◽  
Guinea Pig Brain ◽  
Subcutaneous Inoculation

Pseudorabies virus, Iowa strain ("mad itch"), after passage through guinea pig brain, fails to produce infection in guinea pigs when injected subcutaneously unless enormous doses are employed. Such virus is still pathogenic for rabbits when given subcutaneously and for rabbits and guinea pigs intracerebrally. Comparison of the amounts of virus present in the brains of rabbits and guinea pigs following fatal cerebral infection shows that the latter contain, per gram, only approximately one-tenth the amount of virus in the former. Comparing the resistance of the two species to subcutaneously administered pseudorabies virus it has been found that rabbits are approximately 100 times more susceptible than guinea pigs. Over and above the working of these two factors, guinea pig passage appears to achieve some actual attenuation of virus when tested by subcutaneous inoculation into guinea pigs.

scholarly journals Postnatal Guinea Pig Brain Development, as Revealed by Magnetic Resonance and Diffusion Kurtosis Imaging

2020 ◽  
Vol 10 (6) ◽  
pp. 365
Author(s):  
Roger J. Mullins ◽  
Su Xu ◽  
Jiachen Zhuo ◽  
Steve Roys ◽  
Edna F.R. Pereira ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Brain Regions ◽  
Whole Brain ◽  
Pig Brain ◽  
Age Related ◽  
Age Dependent ◽  
Diffusion Kurtosis ◽  
Guinea Pig Brain

This study used in vivo magnetic resonance imaging (MRI) to identify age dependent brain structural characteristics in Dunkin Hartley guinea pigs. Anatomical T2-weighted images, diffusion kurtosis (DKI) imaging, and T2 relaxometry measures were acquired from a cohort of male guinea pigs from postnatal day (PND) 18–25 (juvenile) to PND 46–51 (adolescent) and PND 118–123 (young adult). Whole-brain diffusion measures revealed the distinct effects of maturation on the microstructural complexity of the male guinea pig brain. Specifically, fractional anisotropy (FA), as well as mean, axial, and radial kurtosis in the corpus callosum, amygdala, dorsal-ventral striatum, and thalamus significantly increased from PND 18–25 to PND 118–123. Age-related alterations in DKI measures within these brain regions paralleled the overall alterations observed in the whole brain. Age-related changes in FA and kurtosis in the gray matter-dominant parietal cerebral cortex and dorsal hippocampus were less pronounced than in the other brain regions. The regional data analysis revealed that between-age changes of diffusion kurtosis metrics were more pronounced than those observed in diffusion tensor metrics. The age-related anatomical differences reported here may be important determinants of the age-dependent neurobehavior of guinea pigs in different tasks.

High-frequency oscillations and seizure-like discharges in the entorhinal cortex of the in vitro isolated guinea pig brain

2017 ◽  
Vol 130 ◽  
pp. 21-26 ◽  
Author(s):  
Laura Uva ◽  
Davide Boido ◽  
Massimo Avoli ◽  
Marco de Curtis ◽  
Maxime Lévesque
Keyword(s):  
Guinea Pig ◽  
Entorhinal Cortex ◽  
High Frequency ◽  
High Frequency Oscillations ◽  
Pig Brain ◽  
Guinea Pig Brain

Drug induced changes in free, labile and stable acetylcholine of guinea-pig brain

1969 ◽  
Vol 18 (6) ◽  
pp. 1315-1324 ◽  
Author(s):  
L. Beani ◽  
C. Bianchi ◽  
P. Megazzini ◽  
L. Ballotti ◽  
G. Bernardi
Keyword(s):  
Guinea Pig ◽  
Drug Induced ◽  
Pig Brain ◽  
Induced Changes ◽  
Guinea Pig Brain
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