scholarly journals Extensive Retinal Neovascularization as a Late Finding in Human Immunodeficiency Virus–Infected Patients with Immune Recovery Uveitis

2003 ◽  
Vol 36 (8) ◽  
pp. 1063-1066 ◽  
Author(s):  
Mary E. Wright ◽  
Daniel L. Suzman ◽  
Karl G. Csaky ◽  
Henry Masur ◽  
Michael A. Polis ◽  
...  

2005 ◽  
Vol 15 (5) ◽  
pp. 607-609 ◽  
Author(s):  
G. Modorati ◽  
E. Miserocchi ◽  
R. Brancato

Purpose To report the typing of human leukocyte antigen (HLA) in four human immunodeficiency virus-positive (HIV) patients with immune recovery uveitis (IRU). Methods The medical history of four consecutive patients who presented at the Ocular Immunology and Uveitis Service (University Hospital San Raffaele, Milan, Italy) with definite diagnosis of IRU is reported. The HLA typing was tested in all patients. Results All patients presented the clinical and ophthalmological characteristics of IRU. The HLA typing analysis showed the presence of HLA B 8–18 in all patients. Conclusions The data obtained from these patients indicate the presence of the same HLA typing (B 8–18). The clinical relevance of such association needs to be further evaluated.



2001 ◽  
Vol 183 (4) ◽  
pp. 546-554 ◽  
Author(s):  
Jonathan B. Angel ◽  
Karl G. Parato ◽  
Ashok Kumar ◽  
Stephen Kravcik ◽  
Andrew D. Badley ◽  
...  


Author(s):  
Pope Kosalaraksa ◽  
David C. Boettiger ◽  
Torsak Bunupuradah ◽  
Rawiwan Hansudewechakul ◽  
Sarun Saramony ◽  
...  


2005 ◽  
Vol 15 (4) ◽  
pp. 510-512 ◽  
Author(s):  
E. Miserocchi ◽  
G. Modorati ◽  
R. Brancato

Purpose To report a case of immune recovery uveitis (IRU) in an iatrogenically immunosuppressed human immunodeficiency virus (HIV)-negative patient. Methods Interventional case report. One patient was diagnosed with cytomegalovirus retinitis in the left eye while receiving immunosuppressive treatment following renal transplantation. The retinitis resolved completely with systemic ganciclovir. Further reduction of immunosuppressive treatment, causing a rapid increase in CD4–T lymphocyte count, was associated in the same eye with the occurrence of IRU consisting of anterior uveitis, vitritis, and macular edema. Results Visual acuity at IRU presentation onset was 20/200 in the left eye. After 6 weeks of follow-up, the uveitis resolved with topical and periocular steroid treatment. Visual acuity restored to 20/40. Conclusions IRU can occur in iatrogenically immunosuppressed HIV-negative patients.



2012 ◽  
Vol 6 (1) ◽  
pp. 105-108
Author(s):  
Susana Ruiz Bilbao ◽  
Sandra Gómez Sánchez ◽  
Cristina Tural Llacher ◽  
Ramón Anglada Escalona ◽  
Laura Broc Iturralde ◽  
...  


Author(s):  
Sergio Serrano-Villar ◽  
Sergio Sanchez-Carrillo ◽  
Alba Talavera-Rodríguez ◽  
Benjamin Lelouvier ◽  
Carolina Gutiérrez ◽  
...  

Abstract Human immunodeficiency virus (HIV) infection impairs mucosal immunity and leads to bacterial translocation, fueling chronic inflammation and disease progression. While this is well established, questions remain about the compositional profile of the translocated bacteria, and to what extent it is influenced by antiretroviral therapy (ART). Using 16S ribosomal DNA targeted sequencing and shotgun proteomics, we showed that HIV increases bacterial translocation from the gut to the blood. HIV increased alpha diversity in the blood, which was dominated by aerobic bacteria belonging to Micrococcaceae (Actinobacteria) and Pseudomonadaceae (Proteobacteria) families, and the number of circulating bacterial proteins was also increased. Forty-eight weeks of ART attenuated this phenomenon. We found that enrichment with Lactobacillales order, and depletion of Actinobacteria class and Moraxellaceae and Corynebacteriacae families, were significantly associated with greater immune recovery and correlated with several inflammatory markers. Our findings suggest that the molecular cross talk between the host and the translocated bacterial products could influence ART-mediated immune recovery.





1987 ◽  
Vol 1 (3) ◽  
pp. 381-395 ◽  
Author(s):  
Beverly Ryan ◽  
Edward Connor ◽  
Anthony Minnefor ◽  
Frank Desposito ◽  
James Oleske


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