Immune Recovery Uveitis in a iatrogenically Immunosuppressed Patient

2005 ◽  
Vol 15 (4) ◽  
pp. 510-512 ◽  
Author(s):  
E. Miserocchi ◽  
G. Modorati ◽  
R. Brancato
Keyword(s):  
Visual Acuity ◽  
T Lymphocyte ◽  
Immunosuppressive Treatment ◽  
Steroid Treatment ◽  
Immunosuppressed Patient ◽  
Immune Recovery ◽  
Immune Recovery Uveitis ◽  
Immunodeficiency Virus ◽  
Hiv Negative

Purpose To report a case of immune recovery uveitis (IRU) in an iatrogenically immunosuppressed human immunodeficiency virus (HIV)-negative patient. Methods Interventional case report. One patient was diagnosed with cytomegalovirus retinitis in the left eye while receiving immunosuppressive treatment following renal transplantation. The retinitis resolved completely with systemic ganciclovir. Further reduction of immunosuppressive treatment, causing a rapid increase in CD4–T lymphocyte count, was associated in the same eye with the occurrence of IRU consisting of anterior uveitis, vitritis, and macular edema. Results Visual acuity at IRU presentation onset was 20/200 in the left eye. After 6 weeks of follow-up, the uveitis resolved with topical and periocular steroid treatment. Visual acuity restored to 20/40. Conclusions IRU can occur in iatrogenically immunosuppressed HIV-negative patients.

P058 Epidemiological clinical, etiologic spectrum and follow-up results of uveitis in children: a single center experience

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_5) ◽  
Author(s):  
W Messadi ◽  
A Salmi ◽  
N Guemri ◽  
N Cherif
Keyword(s):  
Visual Acuity ◽  
Rheumatic Diseases ◽  
Immunosuppressive Treatment ◽  
Underlying Disease ◽  
Intermediate Uveitis ◽  
Single Center Experience ◽  
Pooled Prevalence ◽  
Tnf Α ◽  
Etiologic Diagnosis

Abstract Background Uveitis refers to the inflammation of the vascular tunic of the eye. This inflammation varies greatly in its clinical expressions and etiologies and is often a majordiagnostic challenge for physicians. These data cover symptoms, clinical examination results, complications, etiologies and treatments Methods A retro-prospective monocentric study was carried out on 22patients hospitalized in the pediatric department of the issaadhassani hospital of Algiers during the period of January 2017 to December 2021. Results The sex ratio is 1,2. Their average age was 8 years (4–15Y). Most of thepatients consulted for the three cardinal signs of uveitis: 81% for a decrease in visual acuity, 59% for redness, and 43% for ocular pain. Uveitis was bilateral in 55% of the cases. Inanatomical localization, 45,5% of patients had total uveitis, 27% had anterior uveitis, and 18% had intermediate uveitis, and 9% had anterior and intermediate uveitis. An etiologic diagnosis was made in 32% of the cases. The most frequent causes were inflammatory. Treatments consisted of local corticosteroid therapy for all thepatients, a general corticoid treatment for all of the patients, associated with an immunosuppressive treatment for 50% and biologic anti TNF α treatment (adalimumab) for23% cases. A good evolution after treatment was noted among patients with visual acuity <3/10 with a substantial decrease from 67% to 2%.77.5% are in remission, 13.5% are improving and 9% are in relapse the duration of the follow-up is 1 ½ years with intervals of 2 months and 5 years. Conclusion The results of the current study are generally compatible with the literature. however. The percentage of etiologies covered remains a point to improve, The pooled prevalence of uveitis in pediatric rheumatic diseases widely varied based on the underlying disease requiring more investigations in different subtypes of rheumatic diseases. The biologic medications, especially Adalimumab are the most effective treatments for uveitis in pediatric rheumatic diseases; however, a combination of the safe, available alternatives is preferred to achieve the most desirable treatment response.

Immune Recovery Uveitis and Human Leukocyte Antigen Typing: A Report on Four Patients

2005 ◽  
Vol 15 (5) ◽  
pp. 607-609 ◽  
Author(s):  
G. Modorati ◽  
E. Miserocchi ◽  
R. Brancato
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Hla Typing ◽  
University Hospital ◽  
Immune Recovery ◽  
Human Leukocyte Antigen Typing ◽  
Immune Recovery Uveitis ◽  
Leukocyte Antigen ◽  
Immunodeficiency Virus ◽  
History Of

Purpose To report the typing of human leukocyte antigen (HLA) in four human immunodeficiency virus-positive (HIV) patients with immune recovery uveitis (IRU). Methods The medical history of four consecutive patients who presented at the Ocular Immunology and Uveitis Service (University Hospital San Raffaele, Milan, Italy) with definite diagnosis of IRU is reported. The HLA typing was tested in all patients. Results All patients presented the clinical and ophthalmological characteristics of IRU. The HLA typing analysis showed the presence of HLA B 8–18 in all patients. Conclusions The data obtained from these patients indicate the presence of the same HLA typing (B 8–18). The clinical relevance of such association needs to be further evaluated.

Radiological Follow-up of Pulmonary Tuberculosis

JMS SKIMS ◽  
2016 ◽  
Vol 19 (1) ◽  
pp. 2-4
Author(s):  
Tariq A Gojwari
Keyword(s):  
Health Problem ◽  
Hiv Positive ◽  
Past Century ◽  
African Region ◽  
The Past ◽  
Immunodeficiency Virus ◽  
Incident Cases ◽  
Global Health Problem ◽  
Hiv Negative

Tuberculosis is a global health problem and is the second leading infectious cause of death, after human immunodeficiency virus (HIV). In 2014, there were an estimated 9.6 million incident cases of TB (range, 9.1 million–10.0 million) globally, equivalent to 133 cases per 100 000 population 1 . Most of the estimated number of cases in 2014 occurred in Asia (58%) and the African Region (28%). The six countries that stood out as having the largest number of incident cases in 2014 were India, Indonesia, China, Nigeria, Pakistan and South Africa. There were an estimated 1.5 million TB deaths in 2014 , 1.1 million among HIV-negative people and 390 000 among HIV- positive people 1 . These numbers show the importance of tuberculosis as a community health problem especially in our part of the world despite the leaps and bounds with which medicine has progressed our the past century. Furthermore, this issue itself has two articles related to tuberculosis by Koul et al and Rangrez et al highlighting the fact that there still is a lot that we have to learn about TB. JMS 2016; 19(1):2-4

Immune recovery uveitis in an HIV-negative individual†

2007 ◽  
Vol 35 (2) ◽  
pp. 189-190 ◽  
Author(s):  
Michelle L Baker ◽  
Penelope Allen ◽  
Jake Shortt ◽  
Sharon R Lewin ◽  
Andrew Spencer
Keyword(s):  
Immune Recovery ◽  
Immune Recovery Uveitis ◽  
Hiv Negative

Yield of Primary and Repeat Induced Sputum Testing for Pneumocystis jiroveci in Human Immunodeficiency Virus–Positive and –Negative Patients

2007 ◽  
Vol 131 (10) ◽  
pp. 1582-1584 ◽  
Author(s):  
Yihong Wang ◽  
Saryn Doucette ◽  
Qinfang Qian ◽  
James E. Kirby
Keyword(s):  
Human Immunodeficiency Virus ◽  
Bronchoalveolar Lavage ◽  
Retrospective Review ◽  
Diagnostic Yield ◽  
Invasive Procedure ◽  
Induced Sputum ◽  
Pneumocystis Jiroveci ◽  
Immunodeficiency Virus ◽  
Hiv Negative

Abstract Context.—Induced sputum sampling has an approximate 70% sensitivity for detection of Pneumocystis jiroveci in human immunodeficiency virus (HIV) patients. Bronchoalveolar lavage sampling has greater than 90% sensitivity but is a far more invasive procedure. Therefore, bronchoalveolar lavage testing is often recommended as a follow-up after a negative induced sputum. In HIV-negative patients, the utility of induced sputum testing is still not well defined. Objective.—To determine whether repeat induced sputum sampling increases diagnostic yield and might thereby reduce the need for follow-up bronchoalveolar lavage sampling. To determine the utility of induced sputum sampling in HIV-negative patients. Design.—A 2-year retrospective review of the utility of repeat induced sputa testing in patients with previous first and/or second negative induced sputa. Retrospective review of induced sputa detection in HIV-negative patients. Results.—Repeat testing of induced sputa for Pneumocystic jirovecii did not significantly increase diagnostic yield. Furthermore, in HIV-negative patients, induced sputum testing was diagnostically insensitive. Conclusions.—Bronchoalveolar lavage testing should be performed initially in HIV-negative patients and after a first negative induced sputum in HIV-positive patients.

Optical coherence tomography angiography findings in a case with acute posterior multifocal placoid pigment epitheliopathy

2018 ◽  
Vol 30 (1) ◽  
pp. NP1-NP4
Author(s):  
Fatih Mehmet Türkcü ◽  
Ümit Karaalp ◽  
Muhammed Şahin ◽  
Alparslan Şahin ◽  
Uğur Keklikçi
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Optical Coherence Tomography Angiography ◽  
Imaging Technique ◽  
Late Phase ◽  
Steroid Treatment ◽  
Optical Coherence ◽  
Noninvasive Imaging Technique ◽  
The Right

Twenty-six-year-old male patient admitted to the outpatient clinic with a complaint of decreased vision in both eyes. Visual acuity was 2/10 in the right and 7/10 in the left eye. Fundus examination revealed bilateral yellow-white subretinal lesions involving the macula. Fluorescein angiography showed hypofluorescent lesions in early and hyperflourescent lesions in the late phase. Optical coherence tomography angiography performed in the acute phase showed bilateral hypofluorescency at the choriocapillary level. A diagnosis of acute posterior multifocal placoid pigment epitheliopathy was given. After steroid treatment, visual acuity was improved to 10/10 and earlier lesions in optical coherence tomography angiography were found to be reduced. In conclusion, optical coherence tomography angiography is a noninvasive imaging technique that can be used in the diagnosis and follow-up of acute posterior multifocal placoid pigment epitheliopathy.

scholarly journals Incidence and risk factors of HCV and HIV infections in a cohort of intravenous drug users in the North and East of France

2004 ◽  
Vol 132 (4) ◽  
pp. 699-708 ◽  
Author(s):  
D. LUCIDARME ◽  
A. BRUANDET ◽  
D. ILEF ◽  
J. HARBONNIER ◽  
C. JACOB ◽  
...  
Keyword(s):  
Risk Factors ◽  
Drug Users ◽  
Multivariable Analysis ◽  
Hiv Infections ◽  
The North ◽  
Immunodeficiency Virus ◽  
Serum Test ◽  
Anti Hiv ◽  
Hiv Negative

In order to evaluate the incidence and risk factors of infection by hepatitis C virus (HCV) among injecting drug users (IDUs), we conducted a prospective cohort study of HCV- and human immunodeficiency virus (HIV)-negative IDUs in the North and East of France. A total of 231 HCV and HIV IDUs who had injected drugs at least once in their lifetime were followed up every 3 months over a 12-month period. Serum anti-HCV and anti-HIV were tested at inclusion in the study and at the end of the follow-up. Data on injecting practices were collected at inclusion and at each visit. Of the 231 participants included, 165 (71·4%) underwent a final HCV and HIV serum test. The incidence was nil for HIV infection and 9/100 person-years (95% CI 4·6–13·4) for HCV infection. In a multivariable analysis, we found that syringe and cotton sharing were the only independent predictive factors of HCV seroconversion.

scholarly journals Low CD4+ T-Lymphocyte Values in Human Immunodeficiency Virus-Negative Adults in Botswana

2004 ◽  
Vol 11 (5) ◽  
pp. 930-935 ◽  
Author(s):  
Hermann Bussmann ◽  
C. William Wester ◽  
Kereng V. Masupu ◽  
Trevor Peter ◽  
Sarah M. Gaolekwe ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Lymphocyte ◽  
Blood Donors ◽  
African Country ◽  
Measurement Techniques ◽  
Hiv Disease ◽  
Healthy Human ◽  
Immunodeficiency Virus ◽  
Sub Saharan ◽  
Hiv Negative

ABSTRACT CD4+-lymphocyte counts (LCs) play a crucial role in the management and monitoring of HIV infection. Variability in CD4+ LCs has been reported to occur as a result of measurement techniques and/or biological variations. We report on the CD4+ LCs of healthy human immunodeficiency virus (HIV)-seronegative adults in Botswana. Samples were obtained from HIV-seronegative blood donors. The median CD4+ LC was 726 cells/mm3 (for females, 782 cells/mm3; for males, 698 cells/mm3). The median CD8+ LC was 488 cells/mm3 (for females, 494 cells/mm3; for males, 485 cells/mm3). The median CD4+-to-CD8+ ratio was 1.57 (for females, 1.66; for males, 1.51). Our findings of low CD4+ LCs among HIV-negative adults in Botswana are significant and have important implications for the management of HIV disease in the population of this sub-Saharan African country.

scholarly journals Extensive Retinal Neovascularization as a Late Finding in Human Immunodeficiency Virus–Infected Patients with Immune Recovery Uveitis

2003 ◽  
Vol 36 (8) ◽  
pp. 1063-1066 ◽  
Author(s):  
Mary E. Wright ◽  
Daniel L. Suzman ◽  
Karl G. Csaky ◽  
Henry Masur ◽  
Michael A. Polis ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Retinal Neovascularization ◽  
Immune Recovery ◽  
Immune Recovery Uveitis ◽  
Immunodeficiency Virus ◽  
Late Finding

Kaposi Sarcoma of the Penis in an HIV-Negative Patient

2011 ◽  
Vol 15 (2) ◽  
pp. 118-120 ◽  
Author(s):  
Roberto Cecchi ◽  
Michela Troiano ◽  
Maurizia Ghilardi ◽  
Laura Bartoli
Keyword(s):  
Unusual Case ◽  
Kaposi Sarcoma ◽  
Unusual Site ◽  
Case Presentation ◽  
Negative Patient ◽  
Immunodeficiency Virus ◽  
Nodular Lesions ◽  
Immunocompetent Patients ◽  
Hiv Negative

Background: The penis is an unusual site of presentation for Kaposi sarcoma, especially in immunocompetent patients. Case Presentation: A 52-year-old human immunodeficiency virus (HIV)-seronegative man presented with a reddish, 8 mm in diameter nodule on the glans penis near the coronal sulcus. Histopathology after excision of the lesion was consistent with Kaposi sarcoma. No other cutaneous or mucosal manifestations were present. After a follow-up period of 2 years, no recurrence was observed. Conclusion: This unusual case suggests that Kaposi sarcoma should be considered in the differential diagnosis of macular, papular, and nodular lesions involving the penis.

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