Focused ultrasound mediated drug delivery from temperature-sensitive liposomes: in-vitro characterization and validation

2013 ◽  
Vol 58 (22) ◽  
pp. 8135-8151 ◽  
Author(s):  
J-M Escoffre ◽  
A Novell ◽  
M de Smet ◽  
A Bouakaz
Keyword(s):  
Drug Delivery ◽  
Focused Ultrasound ◽  
Temperature Sensitive ◽  
In Vitro Characterization

A Smart Drug Delivery System Based on Thermo-Responsive Polymer Gated Au NRs@SiO2 Nano-Platform

2021 ◽  
Vol 16 (7) ◽  
pp. 1029-1036
Author(s):  
Hongzhu Wang ◽  
Mengxun Chen ◽  
Liping Song ◽  
Youju Huang
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Photothermal Therapy ◽  
Drug Loading ◽  
Temperature Sensitive

A key challenge for nanoparticles-based drug delivery system is to achieve manageable drug release in tumour cell. In this study, a versatile system combining photothermal therapy and controllable drug release for tumour cells using temperature-sensitive block copolymer coupled Au NRs@SiO2 is reported. While the Au NRs serve as hyperthermal agent and the mesoporous silica was used to improve the drug loading and decrease biotoxicity. The block copolymer acted as “gatekeeper” to regulate the release of model drug (Doxorubicin hydrochloride, DOX). Through in vivo and in vitro experiments, we achieved the truly controllable drug release and photothermal therapy with the collaborative effect of the three constituents of the nanocomposites. The reported nanocomposites pave the way to high-performance controllable drug release and photothermal therapy system.

scholarly journals Porous Bioactive Glass Scaffolds for Local Drug Delivery in Osteomyelitis: Development and In Vitro Characterization

2010 ◽  
Vol 11 (4) ◽  
pp. 1675-1683 ◽  
Author(s):  
Chidambaram Soundrapandian ◽  
Someswar Datta ◽  
Biswanath Kundu ◽  
Debabrata Basu ◽  
Biswanath Sa
Keyword(s):  
Drug Delivery ◽  
Bioactive Glass ◽  
Local Drug Delivery ◽  
In Vitro Characterization
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