scholarly journals The electric field distribution in the brain during TTFields therapy and its dependence on tissue dielectric properties and anatomy: a computational study

2015 ◽  
Vol 60 (18) ◽  
pp. 7339-7357 ◽  
Author(s):  
Cornelia Wenger ◽  
Ricardo Salvador ◽  
Peter J Basser ◽  
Pedro C Miranda
Keyword(s):  
Dielectric Properties ◽  
Electric Field ◽  
Field Distribution ◽  
Electric Field Distribution ◽  
Computational Study ◽  
The Brain

Optimizing electric field distribution via tuning cross-linked point size for improving the dielectric properties of polymer nanocomposites

Nanoscale ◽  
2020 ◽  
Vol 12 (23) ◽  
pp. 12416-12425
Author(s):  
Jie Liu ◽  
Yu Zhang ◽  
Zhaoyang Wang ◽  
Jiale Ding ◽  
Shuhui Yu ◽  
...  
Keyword(s):  
Dielectric Properties ◽  
Electric Field ◽  
Polymer Nanocomposites ◽  
Field Distribution ◽  
Chemical Bonding ◽  
Electric Field Distribution

All chemical bonding cross-linked nanocomposites were designed via tuning cross-linked points size for improving dielectric properties.

scholarly journals Predicting the electric field distribution in the brain for the treatment of glioblastoma

2014 ◽  
Vol 59 (15) ◽  
pp. 4137-4147 ◽  
Author(s):  
Pedro C Miranda ◽  
Abeye Mekonnen ◽  
Ricardo Salvador ◽  
Peter J Basser
Keyword(s):  
Electric Field ◽  
Field Distribution ◽  
Electric Field Distribution ◽  
The Brain

Modelling of the electric field distribution in the brain during tDCS

2016 ◽  
Vol 31 (5) ◽  
Author(s):  
Alexander V. Ashikhmin ◽  
Rubin R. Aliev
Keyword(s):  
Spatial Distribution ◽  
Electric Field ◽  
Field Distribution ◽  
Direct Current ◽  
Electric Field Distribution ◽  
Human Head ◽  
Head Model ◽  
Electrode Size ◽  
Common Electrode ◽  
The Brain

AbstractWe simulated the electric current distribution in the brain during transcranial direct current stimulation (tDCS) using an anatomically accurate human head model. We estimated an effect of common electrode montages on spatial distribution of the electric field during tDCS procedure and analyzed a sensitivity of the technique to variations of electrode size and orientation. We concluded that the used electrode montages are stable with respect to minor changes in electrode size and position, while an assumption of homogeneity and isotropy of the head model results in crucial changes of the electric field distribution. We determined the electrode montages suited to deliver strong effect on hippocampus and cerebellum.

scholarly journals Direct-Current Electric Field Distribution in the Brain for Tumor Treating Field Applications: A Simulation Study

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Yung-Shin Sun
Keyword(s):  
Electric Field ◽  
Field Distribution ◽  
Electric Fields ◽  
Direct Current ◽  
Electric Field Distribution ◽  
Total Power ◽  
Head Model ◽  
Direct Current Electric Field ◽  
The Brain ◽  
Current Electric Field

Tumor Treating Fields (TTFields) in combination with chemotherapy and/or radiotherapy have been clinically reported to provide prolonged overall survival in glioblastoma patients. Alternating electric fields with frequencies of 100~300 kHz and magnitudes of 1~3 V/cm are shown to suppress the growth of cancer cells via interactions with polar molecules within dividing cells. Since it is difficult to directly measure the electric fields inside the brain, simulation models of the human head provide a useful tool for predicting the electric field distribution. In the present study, a three-dimensional finite element head model consisting of the scalp, the skull, the dura, the cerebrospinal fluid, and the brain was built to study the electric field distribution under various applied potentials and electrode configurations. For simplicity, a direct-current electric field was used in the simulation. The total power dissipation and temperature elevation due to Joule heating in different head tissues were also evaluated. Based on the results, some guidelines are obtained in designing the electrode configuration for personalized glioblastoma electrotherapy.

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