Two-step spatially offset Raman spectroscopy technique for rapid and non-invasive detection of drugs in containers—simulation and experiment

2021 ◽  
Vol 18 (12) ◽  
pp. 125601
Author(s):  
Chaoyi Zhang ◽  
Meizhen Huang ◽  
Lili Kong
Keyword(s):  
Raman Spectroscopy ◽  
Spectroscopy Technique ◽  
Non Invasive ◽  
Simulation And Experiment

scholarly journals Raman Spectroscopy Technique: A Non-Invasive Tool in Celiac Disease Diagnosis

Diagnostics ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1277
Author(s):  
Giuseppe Acri ◽  
Claudio Romano ◽  
Stefano Costa ◽  
Salvatore Pellegrino ◽  
Barbara Testagrossa
Keyword(s):  
Raman Spectroscopy ◽  
Celiac Disease ◽  
Roc Curves ◽  
Disease Diagnosis ◽  
Youden Index ◽  
Upper Gastrointestinal Endoscopy ◽  
Spectroscopy Technique ◽  
Serum Samples ◽  
Non Invasive ◽  
Duodenal Lesions

Celiac disease (CD) is diagnosed by a combination of specific serology and typical duodenal lesions. The histological confirmation of CD, mandatory in the majority of patients with suspected CD, is based on invasive and poorly tolerated procedures, such as upper gastrointestinal endoscopy. In this study we propose an alternative and non-invasive methodology able to confirm the diagnosis of CD based on the analysis of serum samples using the Raman spectroscopy technique. Three different bands centered at 1650, 1450 and 1003 cm−1 have been considered and the A1450/A1003 and A1650/A1003 ratios have been computed to discriminate between CD and non-CD subjects. The reliability of the methodology was validated by statistical analysis using receiver operating characteristic (ROC) curves. The Youden index was also determined to obtain optimal cut-off points. The obtained results highlighted that the proposed methodology was able to distinguish between CD and non-CD subjects with 98% accuracy. The optimal cut-off points revealed, for both the A1450/A1003 and A1650/A1003 ratios, high values of sensitivity and specificity (>95.0% and >92.0% respectively), confirming that Raman spectroscopy may be considered a valid alternative to duodenal biopsy and demonstrates spectral changes in the secondary structures of the protein network.

scholarly journals Material characterisation of a painted beehive panel by advanced spectroscopic and chromatographic techniques in combination with hyperspectral imaging

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Klara Retko ◽  
Maša Kavčič ◽  
Lea Legan ◽  
Polonca Ropret ◽  
Bojana Rogelj Škafar ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Hyperspectral Imaging ◽  
Cross Sections ◽  
Extreme Temperature ◽  
Transformation Products ◽  
Paint Layer ◽  
Non Invasive ◽  
Painting Technique ◽  
Invasive Techniques ◽  
Conservation Interventions

AbstractIn this study, a painted beehive panel from the collection of the Slovene Ethnographic Museum was examined with respect to its material composition with the aim to reveal the painting technique. Due to the state of degradation due to outdoor weathering (UV irradiation, rainfall, extreme temperature and humidity fluctuations), as well as past conservation interventions, the object represented a complex analytical challenge. We aimed for non-invasive techniques (FTIR in reflection mode, Raman spectroscopy and hyperspectral imaging in the range of 400–2500 nm); however, in order to explore paint layers, cross-sections were also analysed using Raman spectroscopy. FTIR spectroscopy in transmission mode and gas chromatography coupled to mass spectrometry were also used on sample fragments. Various original materials were identified such as pigments and binders. The surface coating applied during conservation interventions was also characterised. Additionally, organic compounds were found (oxalate, carboxylate), representing transformation products. The potential use of Prussian blue as a background paint layer is discussed.

Local strain measurements in shallow trench insulator structures using near-ultraviolet Raman spectroscopy: Simulation and experiment

2007 ◽  
Vol 102 (10) ◽  
pp. 103506 ◽  
Author(s):  
Eddy Latu-Romain ◽  
Michel Mermoux ◽  
Alexandre Crisci ◽  
Dominique Delille ◽  
Laurens F. Tz. Kwakman
Keyword(s):  
Raman Spectroscopy ◽  
Local Strain ◽  
Strain Measurements ◽  
Near Ultraviolet ◽  
Simulation And Experiment

Non-invasive analysis of hormonal variations and effect of postmenopausal Vagifem treatment on women using in vivo high wavenumber confocal Raman spectroscopy

The Analyst ◽  
2013 ◽  
Vol 138 (14) ◽  
pp. 4120 ◽  
Author(s):  
Shiyamala Duraipandian ◽  
Wei Zheng ◽  
Joseph Ng ◽  
Jeffrey J. H. Low ◽  
A. Ilancheran ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Confocal Raman Spectroscopy ◽  
Non Invasive ◽  
Confocal Raman

scholarly journals Deep Raman spectroscopy for the non-invasive standoff detection of concealed chemical threat agents

Talanta ◽  
2012 ◽  
Vol 94 ◽  
pp. 342-347 ◽  
Author(s):  
Emad L. Izake ◽  
Biju Cletus ◽  
William Olds ◽  
Shankaran Sundarajoo ◽  
Peter M. Fredericks ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Non Invasive ◽  
Standoff Detection

scholarly journals Development of a flow cell based Raman spectroscopy technique to overcome photodegradation in human blood

2019 ◽  
Vol 10 (5) ◽  
pp. 2275 ◽  
Author(s):  
Ben Hansson ◽  
Christian Harry Allen ◽  
Sami Qutob ◽  
Bradford Behr ◽  
Balazs Nyiri ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Human Blood ◽  
Flow Cell ◽  
Spectroscopy Technique

U(VI) speciation studies by Raman spectroscopy technique in the production of nuclear fuel

2022 ◽  
Vol 145 ◽  
pp. 104122
Author(s):  
Laura J. Bonales ◽  
Nieves Rodríguez-Villagra ◽  
Iván Sánchez-García ◽  
Oscar R. Montoro
Keyword(s):  
Raman Spectroscopy ◽  
Nuclear Fuel ◽  
Spectroscopy Technique

Raman Spectroscopy System for Non-invasive Blood Glucose Detection

2017 ◽  
Vol 46 (8) ◽  
pp. 812005 ◽  
Author(s):  
郑毅 ZHENG Yi ◽  
朱香平 ZHU Xiang-ping ◽  
聂荣志 NIE Rong-zhi ◽  
高飞 GAO Fei ◽  
崔晓霞 CUI Xiao-xia ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Blood Glucose ◽  
Glucose Detection ◽  
Non Invasive ◽  
Spectroscopy System

Nanopores and nanosheets of α-Fe2O3 synthetized by electrochemical anodization and analysed by Raman spectroscopy

MRS Advances ◽  
2019 ◽  
Vol 4 (53) ◽  
pp. 2863-2871
Author(s):  
L.M.C. Pérez-Pérez ◽  
A. Báez-Rodríguez ◽  
L. García-González ◽  
J. Hernández-Torres ◽  
O. Velázquez-Camilo ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Crystalline Structure ◽  
Room Temperature ◽  
Ammonium Fluoride ◽  
Deionized Water ◽  
Electrochemical Anodization ◽  
Vibration Modes ◽  
Spectroscopy Technique ◽  
Temperature Scanning ◽  
Static Conditions

Abstract:Nanoparticles and nanopores of iron oxide were synthesized by electrochemical anodization, in an electrolytic medium of ammonium fluoride (NH4F), deionized water and ethylene glycol. After anodization, the Fe foils were annealed at 450 °C for 2 hours. Different anodization times and two concentrations of NH4F (0.1 M and 1.2 M) were evaluated, under static conditions at room temperature. Scanning Electron Microscopy showed nanopores (0.1 M) and nanoparticles (1.2 M). Eight vibration modes characteristic of α-Fe2O3 were found with Raman spectroscopy technique. Relationship between the modes Eu(LO) and 2Eu(LO) was found, therefore, their association with the disorder in the crystalline structure can be determined and it was also found that 2Eu(LO) intensity mode at a concentration of 1.2 M is larger than 0.1 M nanostructures, the FWHM of the A1g mode at 227 cm-1 corresponding to the Fe3+ ions and the Eg at 293 cm-1 mode caused by the O2- ions was also analyzed and founded that the crystalline structure of hematite can be determined by the A1g mode at 227 cm-1.

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