Two-step spatially offset Raman spectroscopy technique for rapid and non-invasive detection of drugs in containers—simulation and experiment

2021 ◽  
Vol 18 (12) ◽  
pp. 125601
Author(s):  
Chaoyi Zhang ◽  
Meizhen Huang ◽  
Lili Kong
Diagnostics ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1277
Author(s):  
Giuseppe Acri ◽  
Claudio Romano ◽  
Stefano Costa ◽  
Salvatore Pellegrino ◽  
Barbara Testagrossa

Celiac disease (CD) is diagnosed by a combination of specific serology and typical duodenal lesions. The histological confirmation of CD, mandatory in the majority of patients with suspected CD, is based on invasive and poorly tolerated procedures, such as upper gastrointestinal endoscopy. In this study we propose an alternative and non-invasive methodology able to confirm the diagnosis of CD based on the analysis of serum samples using the Raman spectroscopy technique. Three different bands centered at 1650, 1450 and 1003 cm−1 have been considered and the A1450/A1003 and A1650/A1003 ratios have been computed to discriminate between CD and non-CD subjects. The reliability of the methodology was validated by statistical analysis using receiver operating characteristic (ROC) curves. The Youden index was also determined to obtain optimal cut-off points. The obtained results highlighted that the proposed methodology was able to distinguish between CD and non-CD subjects with 98% accuracy. The optimal cut-off points revealed, for both the A1450/A1003 and A1650/A1003 ratios, high values of sensitivity and specificity (>95.0% and >92.0% respectively), confirming that Raman spectroscopy may be considered a valid alternative to duodenal biopsy and demonstrates spectral changes in the secondary structures of the protein network.


2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Klara Retko ◽  
Maša Kavčič ◽  
Lea Legan ◽  
Polonca Ropret ◽  
Bojana Rogelj Škafar ◽  
...  

AbstractIn this study, a painted beehive panel from the collection of the Slovene Ethnographic Museum was examined with respect to its material composition with the aim to reveal the painting technique. Due to the state of degradation due to outdoor weathering (UV irradiation, rainfall, extreme temperature and humidity fluctuations), as well as past conservation interventions, the object represented a complex analytical challenge. We aimed for non-invasive techniques (FTIR in reflection mode, Raman spectroscopy and hyperspectral imaging in the range of 400–2500 nm); however, in order to explore paint layers, cross-sections were also analysed using Raman spectroscopy. FTIR spectroscopy in transmission mode and gas chromatography coupled to mass spectrometry were also used on sample fragments. Various original materials were identified such as pigments and binders. The surface coating applied during conservation interventions was also characterised. Additionally, organic compounds were found (oxalate, carboxylate), representing transformation products. The potential use of Prussian blue as a background paint layer is discussed.


2007 ◽  
Vol 102 (10) ◽  
pp. 103506 ◽  
Author(s):  
Eddy Latu-Romain ◽  
Michel Mermoux ◽  
Alexandre Crisci ◽  
Dominique Delille ◽  
Laurens F. Tz. Kwakman

The Analyst ◽  
2013 ◽  
Vol 138 (14) ◽  
pp. 4120 ◽  
Author(s):  
Shiyamala Duraipandian ◽  
Wei Zheng ◽  
Joseph Ng ◽  
Jeffrey J. H. Low ◽  
A. Ilancheran ◽  
...  

Talanta ◽  
2012 ◽  
Vol 94 ◽  
pp. 342-347 ◽  
Author(s):  
Emad L. Izake ◽  
Biju Cletus ◽  
William Olds ◽  
Shankaran Sundarajoo ◽  
Peter M. Fredericks ◽  
...  

2019 ◽  
Vol 10 (5) ◽  
pp. 2275 ◽  
Author(s):  
Ben Hansson ◽  
Christian Harry Allen ◽  
Sami Qutob ◽  
Bradford Behr ◽  
Balazs Nyiri ◽  
...  

2022 ◽  
Vol 145 ◽  
pp. 104122
Author(s):  
Laura J. Bonales ◽  
Nieves Rodríguez-Villagra ◽  
Iván Sánchez-García ◽  
Oscar R. Montoro

2017 ◽  
Vol 46 (8) ◽  
pp. 812005 ◽  
Author(s):  
郑毅 ZHENG Yi ◽  
朱香平 ZHU Xiang-ping ◽  
聂荣志 NIE Rong-zhi ◽  
高飞 GAO Fei ◽  
崔晓霞 CUI Xiao-xia ◽  
...  

MRS Advances ◽  
2019 ◽  
Vol 4 (53) ◽  
pp. 2863-2871
Author(s):  
L.M.C. Pérez-Pérez ◽  
A. Báez-Rodríguez ◽  
L. García-González ◽  
J. Hernández-Torres ◽  
O. Velázquez-Camilo ◽  
...  

Abstract:Nanoparticles and nanopores of iron oxide were synthesized by electrochemical anodization, in an electrolytic medium of ammonium fluoride (NH4F), deionized water and ethylene glycol. After anodization, the Fe foils were annealed at 450 °C for 2 hours. Different anodization times and two concentrations of NH4F (0.1 M and 1.2 M) were evaluated, under static conditions at room temperature. Scanning Electron Microscopy showed nanopores (0.1 M) and nanoparticles (1.2 M). Eight vibration modes characteristic of α-Fe2O3 were found with Raman spectroscopy technique. Relationship between the modes Eu(LO) and 2Eu(LO) was found, therefore, their association with the disorder in the crystalline structure can be determined and it was also found that 2Eu(LO) intensity mode at a concentration of 1.2 M is larger than 0.1 M nanostructures, the FWHM of the A1g mode at 227 cm-1 corresponding to the Fe3+ ions and the Eg at 293 cm-1 mode caused by the O2- ions was also analyzed and founded that the crystalline structure of hematite can be determined by the A1g mode at 227 cm-1.


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