Application of plackett-burman design on screening the factors affecting torrefaction of palm kernel shell

Introduction: Nanoparticle formulation of pitavastatin calcium is a potential alternative to solve the solubility related problem. However, the formulation of nanoparticle involves various parameters that affect product quality. Plackett-Burman design could facilitate an economical experimental plan that focuses on determining the relative significance of many. Aim: The objective of this study was to screen the variables which could significantly affect the pitavastatin nanoparticle formulation. Materials and methods: The pitavastatin nanoparticles were formulated by preparing nanosuspension using the emulsion solvent evaporation technique followed by freeze-drying. A Plackett-Burman screening design methodology was employed in which seven factors at two levels were tested at 12 runs to study the effect of formulation and process variables on particle size and polydispersity index of nanoparticles. The surface morphology and crystalline nature of nanoparticle were also evaluated. Results: The particle size and polydispersity index of nanosuspension was found in the range of 113.1 to 768.5 nm and 0.068 to 0.508, respectively. Statistical analysis of various variables revealed that stabilizer concentration, injection flow rate, and stirring rate were the most influential factors affecting the particle size and polydispersity index of the formulation. X-ray diffraction (XRD) and scanning electron microscopy (SEM) study suggested the amorphous nature of nanoparticles. Conclusions: This study concluded that the Plackett-Burman design was an efficient tool for screening the process and formulation variables affecting the properties of pitavastatin nanoparticles and also for the identification of the most prominent factor.

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Factors affecting endoglucanase production by Trichoderma reesei RUT C-30 from solid state fermentation of oil palm empty fruit bunches using Plackett-Burman design

AFRICAN JOURNAL OF BIOTECHNOLOGY ◽

10.5897/ajb11.008 ◽

2011 ◽

Vol 10 (46) ◽

pp. 9402-9409 ◽

Cited By ~ 2

Author(s):

Zauri Abdul Wahid Manisya ◽

Salleh Madihah ◽

Yusof Faridah ◽

Ismail Abdul Karim Mohammed ◽

Zahangir Alam Md

Keyword(s):

Solid State ◽

Trichoderma Reesei ◽

Solid State Fermentation ◽

Oil Palm ◽

Factors Affecting ◽

Empty Fruit Bunches ◽

Burman Design ◽

C 30 ◽

Plackett Burman Design

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Application of the Plackett-Burman design to determine the main factors affecting the anti-oxidative activity of goat's milk casein hydrolyzed by Alcalase and papain

Acta Scientiarum Polonorum Technologia Alimentaria ◽

10.17306/j.afs.0580 ◽

2018 ◽

Vol 17 (3) ◽

pp. 257-266 ◽

Cited By ~ 1

Author(s):

Guowei Shu ◽

◽

Sha Mei ◽

Qian Zhang ◽

Ni Xin ◽

...

Keyword(s):

Oxidative Activity ◽

Factors Affecting ◽

Goat’S Milk ◽

Burman Design ◽

Main Factors ◽

Goat's Milk ◽

Milk Casein ◽

Plackett Burman Design

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PLACKETT–BURMAN DESIGN AS A TOOL FOR SCREENING AND PROCESS OPTIMIZATION OF RIVASTIGMINE-LOADED LIPID NANOCARRIERS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i12.28066 ◽

2018 ◽

Vol 11 (12) ◽

pp. 155

Author(s):

Anubhav Anand ◽

Gyanendra Singh ◽

Shubhini A Saraf

Keyword(s):

Particle Size ◽

Entrapment Efficiency ◽

Diffusion Method ◽

P Value ◽

Sonication Time ◽

Sugar Ester ◽

Factors Affecting ◽

Lipid Nanocarriers ◽

Burman Design ◽

Plackett Burman Design

Objective: Plackett–Burman experimental design is used to identify the most important factors early in the experimentation phase when complete knowledge about the system is usually unavailable. The objective of this study was to screen out the most important factors affecting the size and entrapment efficiency of rivastigmine hydrogen tartrate (RHT) nanostructured lipid carriers (NLCs).Methods: The RHT-loaded NLC was prepared by the modified solvent emulsification-diffusion method. The independent variables selected for Plackett–Burman design were drug: lipid ratio, solid lipid/liquid lipid (S/L) ratio, concentration Ryoto sugar ester (%w/v), the concentration of poloxamer 188 (%w/v), sonication time (min), sonication amplitude, and stirring time (h).Results: The R2 value for the particle size equation was 86.16%. p value was (<0.05) 0.048 in case of sonication time. In case of entrapment efficiency, the R2 value was 87.12%. The p value (p<0.05) for S/L ratio and the Ryoto sugar (% w/v) was 0.028 and 0.042, respectively.Conclusion: It can be concluded that sonication time has a significant effect on particle size, whereas S/L ratio and Ryoto sugar ester concentration have a significant effect on entrapment efficiency.

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