Molecular Epidemiology of Methicillin-ResistantStaphylococcus aureusin Colombian Hospitals: Dominance of a Single Unique Multidrug-Resistant Clone

2001 ◽  
Vol 7 (1) ◽  
pp. 23-32 ◽  
Author(s):  
A.R. Gomes ◽  
I. Santos Sanches ◽  
M. Aires de Sousa ◽  
E. Castañeda ◽  
H. de Lencastre
Keyword(s):  
Molecular Epidemiology ◽  
Multidrug Resistant ◽  
Resistant Clone

scholarly journals Molecular Epidemiology of Multidrug-Resistant Klebsiella pneumoniae Isolates in a Brazilian Tertiary Hospital

2019 ◽  
Vol 10 ◽  
Author(s):  
Jussara Kasuko Palmeiro ◽  
Robson Francisco de Souza ◽  
Marcos André Schörner ◽  
Hemanoel Passarelli-Araujo ◽  
Ana Laura Grazziotin ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Molecular Epidemiology ◽  
Tertiary Hospital ◽  
Multidrug Resistant

Institutional Outbreak and Control of a Multidrug-Resistant Clone of Acinetobacter baumannii

2009 ◽  
Vol 17 (4) ◽  
pp. 253-257 ◽  
Author(s):  
Joseph W. Gross ◽  
John F. Keiser ◽  
Afifa Klouj ◽  
David M. Parenti ◽  
Gary L. Simon
Keyword(s):  
Acinetobacter Baumannii ◽  
Multidrug Resistant ◽  
Resistant Clone ◽  
And Control

Isolation and characterization of a new plasmid pSpnP1 from a multidrug-resistant clone of Streptococcus pneumoniae

Plasmid ◽  
2007 ◽  
Vol 58 (1) ◽  
pp. 51-60 ◽  
Author(s):  
Patricia Romero ◽  
Daniel Llull ◽  
Ernesto García ◽  
Tim J. Mitchell ◽  
Rubens López ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Multidrug Resistant ◽  
Resistant Clone ◽  
Isolation And Characterization

Molecular epidemiology of multidrug-resistant Pseudomonas aeruginosa in a French university hospital

2010 ◽  
Vol 76 (4) ◽  
pp. 316-319 ◽  
Author(s):  
P. Cholley ◽  
H. Gbaguidi-Haore ◽  
X. Bertrand ◽  
M. Thouverez ◽  
P. Plésiat ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Molecular Epidemiology ◽  
Multidrug Resistant ◽  
University Hospital

scholarly journals Benchmarking the In Vitro Activities of Moxifloxacin and Comparator Agents against Recent Respiratory Isolates from 377 Medical Centers throughout the United States

2000 ◽  
Vol 44 (10) ◽  
pp. 2645-2652 ◽  
Author(s):  
Mark E. Jones ◽  
Angela M. Staples ◽  
Ian Critchley ◽  
Clyde Thornsberry ◽  
Paul Heinze ◽  
...  
Keyword(s):  
Moraxella Catarrhalis ◽  
The United States ◽  
Multidrug Resistant ◽  
Pulsed Field Gel Electrophoresis ◽  
In Vitro Activity ◽  
Resistant Clone ◽  
Future Studies ◽  
Medical Centers ◽  
Drug Classes

ABSTRACT To benchmark the activity of moxifloxacin (a newer fluoroquinolone), a U.S. study comprising 16,141 contemporary isolates of Streptococcus pneumoniae (5,640), Haemophilus influenzae (6,583), and Moraxella catarrhalis (3,648) referred from 377 institutions during 1998 is described. For S. pneumoniae the modal MIC and MIC at which 90% of the isolates were inhibited (MIC90) for moxifloxacin were 0.12 and 0.25 μg/ml, respectively, independent of susceptibility to other drug classes, geography, or site of infection. Eleven isolates were intermediate or resistant to levofloxacin and grepafloxacin; of these isolates, 1 remained susceptible to sparfloxacin, 2 remained susceptible to moxifloxacin, and 4 remained susceptible to trovafloxacin. All 11 isolates possessed classic mutations ingyrA and/or parC known to confer reduced susceptibility to fluoroquinolones. Four isolates (originating from four separate states) belonging to a multidrug-resistant, fluoroquinolone-resistant clone were identified by pulsed-field gel electrophoresis. For moxifloxacin and trovafloxacin, at least 87% of isolates demonstrated MICs ≥3 twofold concentrations below the susceptibility breakpoints, in contrast to no more than 15% for levofloxacin, grepafloxacin, and sparfloxacin. Of the isolates that were multidrug resistant (7.4%), >98% remained susceptible to moxifloxacin. The modal MIC and MIC90 for M. catarrhalis (both 0.06 μg/ml) and for H. influenzae(both 0.03 μg/ml) were independent of β-lactamase production. These data demonstrate the in vitro activity of moxifloxacin and establish a baseline for future studies.

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