Amplification of a Reactive Oxygen Species Signal in Axotomized Retinal Ganglion Cells

2003 ◽  
Vol 5 (5) ◽  
pp. 629-634 ◽  
Author(s):  
Steve M. Nguyen ◽  
Christa N. Alexejun ◽  
Leonard A. Levin
Keyword(s):  
Reactive Oxygen Species ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Retinal Ganglion ◽  
Reactive Oxygen Species Signal

Rotenone‐induced reactive oxygen species signal the recruitment of STAT3 to mitochondria

FEBS Letters ◽  
2020 ◽  
Vol 594 (9) ◽  
pp. 1403-1412 ◽  
Author(s):  
Fareed Mohammed ◽  
Madhavi Gorla ◽  
Vandana Bisoyi ◽  
Prasad Tammineni ◽  
Naresh Babu V. Sepuri
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Reactive Oxygen Species Signal

scholarly journals The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults

2016 ◽  
Vol 2016 ◽  
pp. 1-23 ◽  
Author(s):  
Małgorzata Nita ◽  
Andrzej Grzybowski
Keyword(s):  
Reactive Oxygen Species ◽  
Optic Neuropathy ◽  
Ganglion Cells ◽  
Current Knowledge ◽  
Reactive Oxygen ◽  
Corneal Dystrophy ◽  
Age Related Macular Degeneration ◽  
Human Lens ◽  
Oxygen Species ◽  
Age Related

The reactive oxygen species (ROS) form under normal physiological conditions and may have both beneficial and harmful role. We search the literature and current knowledge in the aspect of ROS participation in the pathogenesis of anterior and posterior eye segment diseases in adults. ROS take part in the pathogenesis of keratoconus, Fuchs endothelial corneal dystrophy, and granular corneal dystrophy type 2, stimulating apoptosis of corneal cells. ROS play a role in the pathogenesis of glaucoma stimulating apoptotic and inflammatory pathways on the level of the trabecular meshwork and promoting retinal ganglion cells apoptosis and glial dysfunction in the posterior eye segment. ROS play a role in the pathogenesis of Leber’s hereditary optic neuropathy and traumatic optic neuropathy. ROS induce apoptosis of human lens epithelial cells. ROS promote apoptosis of vascular and neuronal cells and stimulate inflammation and pathological angiogenesis in the course of diabetic retinopathy. ROS are associated with the pathophysiological parainflammation and autophagy process in the course of the age-related macular degeneration.

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