Traditional Thermal Therapy with Indirect Moxibustion Decreases Renal Arterial Resistive Index in Patients with Chronic Kidney Disease

2016 ◽  
Vol 22 (4) ◽  
pp. 306-314 ◽  
Author(s):  
Jun Matsumoto-Miyazaki ◽  
Nagisa Miyazaki ◽  
Ichijiro Murata ◽  
Gakuro Yoshida ◽  
Hiroaki Ushikoshi ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Resistive Index ◽  
Thermal Therapy ◽  
Indirect Moxibustion

scholarly journals Mild systemic thermal therapy ameliorates renal dysfunction in a rodent model of chronic kidney disease

2016 ◽  
Vol 310 (11) ◽  
pp. F1206-F1215 ◽  
Author(s):  
Yoshihiro Iwashita ◽  
Takashige Kuwabara ◽  
Manabu Hayata ◽  
Yutaka Kakizoe ◽  
Yuichiro Izumi ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Heat Shock ◽  
Kidney Disease ◽  
Heat Shock Protein ◽  
Heat Shock Protein 27 ◽  
Rodent Model ◽  
Thermal Therapy ◽  
Sham Operation ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Renal Ablation

Thermal therapy has become a nonpharmacological therapy in clinical settings, especially for cardiovascular diseases. However, the practical role of thermal therapy on chronic kidney disease remains elusive. We performed the present study to investigate whether a modified thermal protocol, repeated mild thermal stimulation (MTS), could affect renal damages in chronic kidney disease using a mouse renal ablation model. Mice were subjected to MTS or room temperature (RT) treatment once daily for 4 wk after subtotal nephrectomy (Nx) or sham operation (Sh). We revealed that MTS alleviated renal impairment as indicated by serum creatinine and albuminuria in Nx groups. In addition, the Nx + MTS group showed attenuated tubular histological changes and reduced urinary neutrophil gelatinase-associated lipocalin excretion approximately by half compared with the Nx + RT group. Increased apoptotic signaling, such as TUNEL-positive cell count and cleavage of caspase 3, as well as enhanced oxidative stress were significantly reduced in the Nx + MTS group compared with the Nx + RT group. These changes were accompanied with the restoration of kidney Mn-SOD levels by MTS. Heat shock protein 27, a key molecular chaperone, was phosphorylated by MTS only in Nx kidneys rather than in Sh kidneys. MTS also tended to increase the phosphorylation of p38 MAPK and Akt in Nx kidneys, possibly associated with the activation of heat shock protein 27. Taken together, these results suggest that modified MTS can protect against renal injury in a rodent model of chronic kidney disease.

scholarly journals Renal arterial resistive index is associated with severe histological changes and poor renal outcome during chronic kidney disease

2012 ◽  
Vol 13 (1) ◽  
Author(s):  
Naïke Bigé ◽  
Pierre Patrick Lévy ◽  
Patrice Callard ◽  
Jean-Manuel Faintuch ◽  
Valérie Chigot ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Resistive Index ◽  
Renal Outcome ◽  
Histological Changes

scholarly journals Serum cystatin C is an independent biomarker associated with the renal resistive index in patients with chronic kidney disease

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0193695 ◽  
Author(s):  
Ayu Ogawa-Akiyama ◽  
Hitoshi Sugiyama ◽  
Masashi Kitagawa ◽  
Keiko Tanaka ◽  
Akifumi Onishi ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cystatin C ◽  
Resistive Index ◽  
Renal Resistive Index ◽  
Serum Cystatin C ◽  
Serum Cystatin

Pilot study to evaluate the potential use of the renal resistive index as a preliminary diagnostic tool for chronic kidney disease in cats

2017 ◽  
Vol 20 (10) ◽  
pp. 940-947 ◽  
Author(s):  
Ines Matos ◽  
Pedro Azevedo ◽  
L Miguel Carreira
Keyword(s):  
Chronic Kidney Disease ◽  
Body Weight ◽  
Kidney Disease ◽  
Diagnostic Tool ◽  
Resistive Index ◽  
The Body ◽  
Receiver Operating Curve ◽  
Control Group ◽  
Preliminary Diagnosis ◽  
Potential Use

Objectives Chronic kidney disease (CKD) is the most common renal pathology diagnosed in geriatric cats, and its prevalence increases with age. The arterial resistive index (RI) is important when evaluating vascular resistance and compliance, and can be applied in the kidney (renal RI [RRI]), allowing the evaluation of its vascular haemodynamics. The present study aimed to: (1) investigate in cats with CKD the relationships between the RRI and the following parameters: age, sex, body weight, plasmatic creatinine, blood urea nitrogen, potassium, urine specific gravity, urine protein:creatinine ratio and systolic arterial pressure; and (2) evaluate the potential use of the RRI as a preliminary diagnostic tool in cats with CKD. Methods The present study involved 24 cats of both sexes. Six were healthy cats (control group [CG]) and 18 had CKD, but did not have any concomitant diseases and were not being treated with any medications (study group [SG]). For RRI measurement we used colour Doppler ultrasound (CDUS). Results RRI differed significantly between the CG and SG ( P <0.01) and was higher in the SG. A statistically significant correlation was only achieved between the RRI and the body weight of the patients and it was negative. A strong and positive correlation was noted between the mean RRI of both kidneys (r = 0.66). Receiver–operating curve analysis allowed us to establish an admissible cut-off for the RRI value of 0.639 for a preliminary diagnosis of CKD for both kidneys. Conclusions and relevance No differences were found for the RRI between the left and right kidneys, suggesting that evaluation of only one kidney is sufficient to provide an estimate of the RRI value for both organs. RRI measurement, which can be achieved with CDUS, is an easy-to-use diagnostic tool that, with a cut-off value of 0.639 for both kidneys, is useful in establishing a preliminary diagnosis of CKD.

scholarly journals Markers of chronic kidney disease in high-risk hypertensive patients: relationship with abnormal circadian blood pressure profile and intrarenal vascular resistance

2018 ◽  
Vol 24 (4) ◽  
pp. 478-489 ◽  
Author(s):  
O. A. Koshelskaya ◽  
O. A. Zhuravleva ◽  
R. S. Karpov
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Vascular Resistance ◽  
Resistive Index ◽  
Threshold Value ◽  
Pressure Profile ◽  
Diabetic Patients ◽  
Hypertensive Patients ◽  
Circadian Blood Pressure

Objective. To determine the frequency of markers of chronic kidney disease (CKD) in hypertensive patients, and to assess their relationship with the circadian blood pressure (BP) profile and intrarenal vascular resistance.Design and Methods. We studied 70 patients with medically-controlled hypertension (63,2 ± 8,3 years, m — 48,6 %, office BP was 130,5 ± 13,7 / 78,1 ± 8,5 mm Hg), 40 patients were recruited from the Russian multicentre program CHRONOGRAF. Measurement of the office BP, ambulatory BP monitoring were performed. Glomerular filtration rate (GFR) was calculated using the CKD-EPI formula, and albuminuria (AU) was determined as albumin/creatinine (A/Cr) ratio in the morning portion of urine (n = 40) or 24-hour urinary albumin excretion (UAE) (n = 22). Intrarenal vascular resistance was estimated by renal duplex Doppler ultrasound. The resistive index (RI) levels in the main renal arteries (MRA) and intrarenal arteries (IRA) were calculated.Results. Markers of CKD (GFR < 60 ml/min/1,73 m2and/or A/Cr > 30 mg/g and/or UAE > 30 mg/day) were detected in 31,4 % of patients with well-medically-controlled hypertension: average values of BP-day and BP-night were normal. The frequency of markers of CKD was 44,4 % in patients with BP-night ≥ 120/70 mm Hg (40,9 %) and 28,2 % in patients with BP-night < 120/70 mm Hg (58,1 %). A/Cr ratio was positively associated (Rs = 0,3550, р = 0,0266), GFR was negatively associated (Rs = –0,3795, р = 0,002) with systolic BP-night. RI in the segmental intrarenal arteries correlated with GFR (Rs = –0,4232, p = 0,0005). Renal RI were higher in CKD-patients vs. non-CKD-patients. During the ROC-analysis, the threshold value of RI in segmental IRA 0,725 to the detection of CKD markers (sensitivity of 71,4 %, specificity of 68,9 %, AUC = 0,699) was established. Among the diabetic patients, there were more marked disturbances of renal hemodynamic in the presence of CKD markers: RI in arcuate IRA reached 0,73 (0,68–0,75).Conclusions. The high frequency of markers of CKD (31,4 %) was identified even in patients with well-medically-controlled hypertension, it was associated with systolic BP-night. The negative correlation was found between GFR and RI. Renal hemodynamics was significantly disturbed in the presence of CKD markers, especially in patients with type 2 diabetes mellitus. The cut-off point of RI in segmental IRA indicating the CKD markers is 0,725.

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