Skeletal Muscle Adaptations to Prolonged Exposure to Extreme Altitude: A Role of Physical Activity?

2008 ◽  
Vol 9 (4) ◽  
pp. 311-317 ◽  
Author(s):  
Masao Mizuno ◽  
Gabrielle K Savard ◽  
Nils-Holger Areskog ◽  
Carsten Lundby ◽  
Bengt Saltin
Keyword(s):  
Physical Activity ◽  
Skeletal Muscle ◽  
Prolonged Exposure ◽  
Muscle Adaptations ◽  
Extreme Altitude ◽  
Skeletal Muscle Adaptations

scholarly journals Regulation of PPARγCoactivator-1αFunction and Expression in Muscle: Effect of Exercise

PPAR Research ◽  
2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Giulia Uguccioni ◽  
Donna D'souza ◽  
David A. Hood
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Biogenesis ◽  
Posttranslational Modifications ◽  
Mitochondrial Proteins ◽  
Mitochondrial Content ◽  
Brown Adipose ◽  
Muscle Adaptations ◽  
Genes Encoding ◽  
Skeletal Muscle Adaptations

PPARγcoactivator-1α(PGC-1α) is considered to be a major regulator of mitochondrial biogenesis. Though first discovered in brown adipose tissue, this coactivator has emerged as a coordinator of mitochondrial biogenesis in skeletal muscle via enhanced transcription of many nuclear genes encoding mitochondrial proteins. Stimuli such as exercise provoke the activation of signalling cascades that lead to the induction of PGC-1α. Posttranslational modifications also regulate the function of PGC-1α, with a multitude of upstream molecules targeting the protein to modify its activity and/or expression. Previous research has established a positive correlation between resistance to fatigue and skeletal muscle mitochondrial content. Recently, studies have begun to elucidate the specific role of PGC-1αin exercise-related skeletal muscle adaptations, with several studies identifying it as a dominant regulator of organelle synthesis. This paper will highlight the function, regulation, and expression of PGC-1α, as well as the role of the coactivator during exercise adaptations.

scholarly journals Training program-induced skeletal muscle adaptations in two men with myotonic dystrophy type 1

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Marie-Pier Roussel ◽  
Marika Morin ◽  
Mélina Girardin ◽  
Anne-Marie Fortin ◽  
Mario Leone ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Training Program ◽  
Myotonic Dystrophy ◽  
Myotonic Dystrophy Type 1 ◽  
Myotonic Dystrophy Type ◽  
Muscle Adaptations ◽  
Skeletal Muscle Adaptations

scholarly journals The ontogeny of skeletal muscle adaptations that enable long deep dives in Weddell seals

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Shane B Kanatous ◽  
Thomas J Hawke ◽  
Stephen J Trumble ◽  
Linnea E Pearson ◽  
Randall W Davis
Keyword(s):  
Skeletal Muscle ◽  
Weddell Seals ◽  
Muscle Adaptations ◽  
Skeletal Muscle Adaptations

Skeletal muscle adaptations in elastic resistance-trained young men and women

2001 ◽  
Vol 86 (2) ◽  
pp. 112-118 ◽  
Author(s):  
David Hostler ◽  
Chris Schwirian ◽  
Gerson Campos ◽  
Kumika Toma ◽  
Matthew Crill ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Young Men ◽  
Men And Women ◽  
Elastic Resistance ◽  
Muscle Adaptations ◽  
Skeletal Muscle Adaptations
Sign in / Sign up

Export Citation Format

Share Document