Effectiveness of Combined Tear Film Therapy in Patients with Evaporative Dry Eye with Short Tear Film Breakup Time

2017 ◽  
Vol 33 (8) ◽  
pp. 635-643 ◽  
Author(s):  
Yung Hui Kim ◽  
Yeon Soo Kang ◽  
Hyo Seok Lee ◽  
Won Choi ◽  
In Cheon You ◽  
...  
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Evaporative Dry Eye ◽  
Breakup Time

scholarly journals Maximum blink interval is associated with tear film breakup time: A new simple, screening test for dry eye disease

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Takenori Inomata ◽  
Masao Iwagami ◽  
Yoshimune Hiratsuka ◽  
Keiichi Fujimoto ◽  
Yuichi Okumura ◽  
...  
Keyword(s):  
Dry Eye ◽  
Screening Test ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Breakup Time ◽  
Simple Screening

scholarly journals Diagnostic Test Efficacy of Meibomian Gland Morphology and Function

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Jiaxin Xiao ◽  
Muhammed Yasin Adil ◽  
Jonatan Olafsson ◽  
Xiangjun Chen ◽  
Øygunn A. Utheim ◽  
...  
Keyword(s):  
Dry Eye ◽  
Operating Characteristic ◽  
Characteristic Curve ◽  
Tear Film ◽  
Cross Sectional Study ◽  
Meibomian Gland ◽  
Clinical Parameters ◽  
Cross Sectional ◽  
And Function ◽  
Breakup Time

AbstractMeibomian gland dysfunction (MGD) is the leading cause of dry eye and proposed treatments are based on disease severity. Our purpose was to establish reliable morphologic measurements of meibomian glands for evaluating MGD severity. This retrospective, cross-sectional study included 100 MGD patients and 20 controls. The patients were classified into dry eye severity level (DESL) 1–4 based on symptoms and clinical parameters including tear-film breakup time, ocular staining and Schirmer I. The gland loss, length, thickness, density and distortion were analyzed. We compared the morphology between patients and controls; examined their correlations to meibum expressibility, quality, and DESL. Relative to controls, the gland thickness, density and distortion were elevated in patients (p < 0.001 for all tests). The area under the receiver operating characteristic curve was 0.98 (95% confidence interval [CI], 0.96–1.0) for gland loss, and 0.96 (CI 0.91–1.0) for gland distortion, with a cutoff value of six distorted glands yielding a sensitivity of 93% and specificity of 97% for MGD diagnosis. The gland distortion was negatively correlated to the meibum expressibility (r = −0.53; p < 0.001) and DESL (r = −0.22, p = 0.018). In conclusion, evaluation of meibomian gland loss and distortion are valuable complementary clinical parameters to assess MGD status.

Impact of Nanostructured Lipid Carriers as an Artificial Tear Film in a Rabbit Evaporative Dry Eye Model

Cornea ◽  
2019 ◽  
Vol 38 (4) ◽  
pp. 485-491 ◽  
Author(s):  
Pattravee Niamprem ◽  
Pronnarin Teapavarapruk ◽  
Sangly P. Srinivas ◽  
Waree Tiyaboonchai
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Nanostructured Lipid Carriers ◽  
Artificial Tear ◽  
Eye Model ◽  
Evaporative Dry Eye

scholarly journals "Smart Eye Camera": An innovative technique to evaluate tear film breakup time in a murine dry eye disease model

PLoS ONE ◽  
2019 ◽  
Vol 14 (5) ◽  
pp. e0215130 ◽  
Author(s):  
Eisuke Shimizu ◽  
Yoko Ogawa ◽  
Hiroyuki Yazu ◽  
Naohiko Aketa ◽  
Fan Yang ◽  
...  
Keyword(s):  
Dry Eye ◽  
Disease Model ◽  
Tear Film ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Innovative Technique ◽  
Breakup Time

scholarly journals Short tear film breakup time-type of dry eye in India

2021 ◽  
Vol 69 (12) ◽  
pp. 3463
Author(s):  
Samrat Chatterjee ◽  
Deepshikha Agrawal
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Breakup Time ◽  
Time Type

scholarly journals Tear Film Osmolarity Measurement in Japanese Dry Eye Patients Using a Handheld Osmolarity System

Diagnostics ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 789
Author(s):  
Jun Shimazaki ◽  
Miki Sakata ◽  
Seika Den ◽  
Miki Iwasaki ◽  
Ikuko Toda
Keyword(s):  
Dry Eye ◽  
Surface Condition ◽  
Tear Film ◽  
Japanese Patients ◽  
Prospective Clinical Study ◽  
Prospective Multicenter Study ◽  
Significant Difference ◽  
Related Quality ◽  
Breakup Time

We studied the efficacy and safety of a handheld osmolarity measurement system (I-PEN) in Japanese patients with dry eye disease (DED) and non-DED subjects. In this prospective, multicenter study, tear osmolarity was examined using the I-PEN in a total of 122 eyes divided into DED (n = 71) and non-DED (n = 51) groups. Subjective symptoms were assessed using the Dry Eye-Related Quality-of-Life Score (DEQS) questionnaire. Ocular surface condition was evaluated in terms of fluorescein tear breakup time (FBUT) and tear breakup pattern (TBUP), and by fluorescein staining and Schirmer’s test. The I-PEN measurements were performed safely in the majority of cases. There was no statistically significant difference in mean tear film osmolarity between the DED and non-DED groups (294.76 ± 16.39 vs. 297.76 ± 16.72 mOsms/L, respectively, p = 0.32). No significant correlations were observed between osmolarity values and DEQS score, FBUT, or the Schirmer score. Osmolarity did not differ among TBUP subgroups. This prospective clinical study found no correlations between the tear film osmolarity values obtained with the I-PEN system and any subjective or objective parameters of DED. Further studies are required to determine the utility of the I-PEN system in other settings.

Correlation between Non-Invasive Tear Breakup Time and Invasive Tear Breakup Time for Dry Eye Syndrome Diagnosis

The Eye ◽  
2021 ◽  
Vol 23 (1) ◽  
pp. 15-22
Author(s):  
K. A. Mubarakova ◽  
S. A. Mukhanov ◽  
I. F. Saliyev ◽  
N. H. Habibullayeva
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Optical Power ◽  
Dry Eye Syndrome ◽  
Non Invasive ◽  
Syndrome Diagnosis ◽  
Breakup Time ◽  
Test Result ◽  
Schirmer I Test

Introduction: in today’s digital environment, dry eye complaints step forward in all age groups. Along with dry eye syndrome, the diagnosis of which is not complicated, there are other causes of dryness such as dysfunction of the tear film and Meibomian glands, etc. For the early detection of the above conditions, invasive diagnostic methods are mainly used.Aim: to compare Non-Invasive Tear Breakup Time (NITBUT) assessed with LacryDiag ocular surface analyzer to results of invasive tests for dry eye syndrome diagnosis to determine the possibility of a wider use of LacryDiag in practical ophthalmology. Materials and Methods: 50 patients with dry eye, burning and feeling of a foreign body complaints participated in this study. Mean age amounted to 28.85 ± 5.86 years. NITBUT was assessed with LacryDiag ocular surface analyzer. The data obtained was compared to the results of Invasive Tear Breakup Time (TBUT) – Norne test, and Schirmer I test.Results: both quantitative and qualitative values of tear film stability were analyzed in all participants. Based on results of the Schirmer I test, patients were divided into subgroups: where it was greater than 21 mm, between 11 and 20 mm, between 6 and 10 mm, and less than 5 mm/ The mean value of the Schirmer I test result amounted to 15.32 ± 6.05 mm/5 min, NITBUT amounted to 9.59 ± 4.37 s, while invasive TBUT amounted to 8.98 ± 3.79 s. It was found that invasive TBUT is in a strong direct correlation with NITBUT values (p <0.001, r = 0.554). No correlation was discovered between Schirmer I test results and TBUT (p = 0.15, r = 0.207) as well as between Schirmer I test result and NITBUT (p = 0.17, r =0.228). No correlation was found between the optical power of the cornea and the tear film structure abnormalities.Conclusion: a strong correlation was found between results of invasive and non-invasive methods of tear film breakup time assessment. No correlation was found between the optical power of the cornea and the tear film disruption. The non-invasive test was found to be an effective and objective method for diagnosing dry eye.

A Systematic Approach to Dry Eye using LipiFlow Treatment

2014 ◽  
Vol 07 (02) ◽  
pp. 104 ◽  
Author(s):  
Mitchell A Jackson ◽  
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Inflammatory Markers ◽  
Systematic Approach ◽  
Tear Film ◽  
Meibomian Gland ◽  
Diagnostic Methods ◽  
Therapeutic Options ◽  
Eye Disease ◽  
Evaporative Dry Eye

The complex strategy to understanding dry eye syndrome has led to a widespread change in approaching this condition as an ocular surface disease, stratified as evaporative dry eye, aqueous deficient dry eye, and ocular allergy. The diagnostic armamentarium has vastly expanded to include tear osmolarity and inflammatory markers as redefined by the new International Dry Eye WorkShop (DEWS) in 2007. The Tear Film & Ocular Surface Society (TFOS) panel on meibomian gland dysfunction (MGD) further expanded the interpretation of evaporative dry eye and its therapeutic options, including the newest US Food and Drug Administration (FDA)-approved device known as LipiFlow Thermal Pulsation System. This paper will give an overview on understanding dry eye disease, its etiology, diagnostic methods, and current therapeutic options.

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