Metabolic Syndrome in Inflammatory Bowel Disease: Association with Genetic Markers of Obesity and Inflammation

2020 ◽  
Vol 18 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Sanja Dragasevic ◽  
Biljana Stankovic ◽  
Nikola Kotur ◽  
Aleksandra Sokic-Milutinovic ◽  
Tamara Milovanovic ◽  
...  
2011 ◽  
Vol 140 (5) ◽  
pp. S-350-S-351
Author(s):  
Stephan Brackmann ◽  
Maria E. Pretorius ◽  
Solveig N. Andersen ◽  
Frøydis Langmark ◽  
Ole P.F. Clausen ◽  
...  

2020 ◽  
Vol 158 (6) ◽  
pp. S-937-S-938
Author(s):  
Nicole A. Doria ◽  
Claudia Ramos Rivers ◽  
Maaz Ahsan ◽  
Filippos Koutroumpakis ◽  
Hashash Jana ◽  
...  

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S313-S313
Author(s):  
I V Gubonina ◽  
V Grinevich ◽  
M Poluektov ◽  
T Kolodin ◽  
S Lapteva ◽  
...  

Abstract Background Currently the incidence of patients with Metabolic Syndrome (MS) tends to increase among patients with inflammatory bowel disease (IBD). The purpose of the study is to investigate the course of IBD depending on the presence of MS. Methods This cross-sectional analysis was performed on the database of patients with IBD to estimate the frequency of MS presence and study the clinical course (extension of pathologic process, severity and phenotype) of Crohn’s disease (CD) and ulcerative colitis (UC). Results 347 patients with IBD were included in the investigation: 259 patients with UC and 88 patients with CD. MS was revealed with the same frequency among patients with UC (26 patients, 10.04%) and CD (9 patients, 10.23%). Proctitis (48 patients, 20.6%) and left-sided colitis (121 patients, 51.93%) are usually found among patients with UC without MS while total colitis is significantly more frequent among patients with underlying MS (12, 46.15%, p < 0,05). It was found that patients without MS more often suffered from mild UC (116 patients, 49.79%, p < 0,01) while among patients with MS severe UC occurred more frequently (6 patients, 23.08%, p < 0.05). Among patients with CD and MS, there was no significant correlation between underlying MS and localisation, severity and course of CD. Conclusion Patients with UC and MS suffer from a more severe course of UC (as to both the extension of pathologic process and severity) in comparison with the patients with UC without MS. Due to the small quantity of patient with CD and MS insufficient evidence for the influence of MS on the course of CD has been obtained.


Author(s):  
Edgars Bodnieks ◽  
Aldis Puķītis ◽  
Juris Pokrotnieks

Abstract Nutrition has an important role in the management of inflammatory bowel disease (IBD) and metabolic syndrome (MS). The goal of this study was to assess the nutritive status of patients treated with IBD and metabolic syndrome in the Gastroenterology Centre, Pauls Stradiòð Clinical University Hospital. Body bioelectrical impedance analysis (BIA) using GENIUS 220 PLUS (Jawon Medical) was used to determine Body Mass Index (BMI) kg/m², Metabolic Body Fat (MBF) kg, Soft Lean Mass (SLM) kg, Total Body Water (TBW) kg, body composition, metabolic type, Basal Metabolic Rate (BMR) kcal, and total Energy Expenditure (TEE) kcal in patients with IBD and metabolic syndrome and in a similarly aged control group. The obtained data showed that BMI was not correlated with MBF, BTW and Lean Body Mass (LBM). Patients with Crohn’s disease (CD) had normal value of BMI (M 24.3 kg/m²; F 20.2kg/m²), but we found variety-specific differences in body composition that confirmed deficiency or increase of specific body parameters. The performed prospective study confirmed the importance of the more precise nutritional status analysis, as it was clinically useful for the nutritional management of IBD. Patients with CD had expressed nutrient deficiency, sarcopenia, and reduced amount of proteins and minerals. For patients with MS, sarcopenia was present despite obesity.


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