Spinal Cord Injury Causes Systolic Dysfunction and Cardiomyocyte Atrophy

2018 ◽  
Vol 35 (3) ◽  
pp. 424-434 ◽  
Author(s):  
Jordan W. Squair ◽  
Kathryn M. DeVeau ◽  
Kathryn A. Harman ◽  
Malihe-Sadat Poormasjedi-Meibod ◽  
Brian Hayes ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Systolic Dysfunction ◽  
Cord Injury ◽  
Injury Causes

scholarly journals Lysosomal damage after spinal cord injury causes accumulation of RIPK1 and RIPK3 proteins and potentiation of necroptosis

2018 ◽  
Vol 9 (5) ◽  
Author(s):  
Shuo Liu ◽  
Yun Li ◽  
Harry M. C. Choi ◽  
Chinmoy Sarkar ◽  
Eugene Y. Koh ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cord Injury ◽  
Injury Causes

Chronic spinal cord injury causes upregulation of serotonin (5-HT)2A and 5-HT2C receptors in lumbosacral cord motoneurons

2017 ◽  
Vol 121 (1) ◽  
pp. 145-154 ◽  
Author(s):  
Nailong Cao ◽  
Jianshu Ni ◽  
Xiaohu Wang ◽  
Hongjian Tu ◽  
Baojun Gu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury ◽  
Injury Causes

scholarly journals Spinal Cord Injury Causes Reduction of Galanin and Gastrin Releasing Peptide mRNA Expression in the Spinal Ejaculation Generator of Male Rats

2021 ◽  
Vol 12 ◽  
Author(s):  
James W. Wiggins ◽  
Jonathan E. Sledd ◽  
Lique M. Coolen
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Male Rats ◽  
Lumbar Spinal Cord ◽  
Gastrin Releasing Peptide ◽  
Cord Injury ◽  
Contusion Injury ◽  
Spinal Contusion ◽  
Lumbar Spinal ◽  
Injury Causes

Spinal cord injury (SCI) in men is commonly associated with sexual dysfunction, including anejaculation, and chronic mid-thoracic contusion injury in male rats also impairs ejaculatory reflexes. Ejaculation is controlled by a spinal ejaculation generator consisting of a population of lumbar spinothalamic (LSt) neurons that control ejaculation through release of four neuropeptides including galanin and gastrin releasing peptide (GRP) onto lumbar and sacral autonomic and motor nuclei. It was recently demonstrated that spinal contusion injury in male rats caused reduction of GRP-immunoreactivity, but not galanin-immunoreactivity in LSt cells, indicative of reduced GRP peptide levels, but inconclusive results for galanin. The current study further tests the hypothesis that contusion injury causes a disruption of GRP and galanin mRNA in LSt cells. Male rats received mid-thoracic contusion injury and galanin and GRP mRNA were visualized 8 weeks later in the lumbar spinal cord using fluorescent in situ hybridization. Spinal cord injury significantly reduced GRP and galanin mRNA in LSt cells. Galanin expression was higher in LSt cells compared to GRP. However, expression of the two transcripts were positively correlated in LSt cells in both sham and SCI animals, suggesting that expression for the two neuropeptides may be co-regulated. Immunofluorescent visualization of galanin and GRP peptides demonstrated a significant reduction in GRP-immunoreactivity, but not galanin in LSt cells, confirming the previous observations. In conclusion, SCI reduced GRP and galanin expression in LSt cells with an apparent greater impact on GRP peptide levels. GRP and galanin are both essential for triggering ejaculation and thus such reduction may contribute to ejaculatory dysfunction following SCI in rats.

Spinal cord injury causes insulin resistance associated with PI3K signaling pathway in hypothalamus

2020 ◽  
Vol 140 ◽  
pp. 104839
Author(s):  
Rui-Dong Cheng ◽  
Wen Ren ◽  
Peng Sun ◽  
Liang Tian ◽  
Li Zhang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Signaling Pathway ◽  
Pi3k Signaling ◽  
Cord Injury ◽  
Pi3k Signaling Pathway ◽  
Injury Causes

scholarly journals Spinal Cord Injury Causes Brain Inflammation Associated with Cognitive and Affective Changes: Role of Cell Cycle Pathways

2014 ◽  
Vol 34 (33) ◽  
pp. 10989-11006 ◽  
Author(s):  
J. Wu ◽  
Z. Zhao ◽  
B. Sabirzhanov ◽  
B. A. Stoica ◽  
A. Kumar ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Brain Inflammation ◽  
Cord Injury ◽  
Injury Causes

scholarly journals Spinal Cord Injury Causes Chronic Liver Pathology in Rats

2015 ◽  
Vol 32 (3) ◽  
pp. 159-169 ◽  
Author(s):  
Andrew D. Sauerbeck ◽  
J. Lukas Laws ◽  
Veera V.R. Bandaru ◽  
Phillip G. Popovich ◽  
Norman J. Haughey ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Chronic Liver ◽  
Liver Pathology ◽  
Cord Injury ◽  
Injury Causes

scholarly journals Spinal Cord Injury Causes Sustained Disruption of the Blood-Testis Barrier in the Rat

PLoS ONE ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. e16456 ◽  
Author(s):  
Jennifer N. Dulin ◽  
Meredith L. Moore ◽  
Kevin W. Gates ◽  
Joanna H. Queen ◽  
Raymond J. Grill
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cord Injury ◽  
Injury Causes ◽  
Blood Testis Barrier

scholarly journals Severe Spinal Cord Injury Causes Immediate Multi-cellular Dysfunction at the Chondro-Osseous Junction

2011 ◽  
Vol 2 (4) ◽  
pp. 643-650 ◽  
Author(s):  
Leslie R. Morse ◽  
Yan Xu ◽  
Bethlehem Solomon ◽  
Lara Boyle ◽  
Subbiah Yoganathan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cord Injury ◽  
Cellular Dysfunction ◽  
Injury Causes
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