Respiratory Syncytial Virus and Childhood Asthma

2000 ◽  
Vol 14 (2) ◽  
pp. 91-92 ◽  
Author(s):  
John T. McBride
Keyword(s):  
Respiratory Syncytial Virus ◽  
Childhood Asthma ◽  
Syncytial Virus

Influence of Previous Respiratory Infection on the Association between Respiratory Syncytial Virus Hospitalization and Childhood Asthma

2020 ◽  
Author(s):  
Richard Thwaites ◽  
Jonathan Coutts ◽  
John Fullarton ◽  
ElizaBeth Grubb ◽  
Carole Morris ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Respiratory Infection ◽  
Childhood Asthma ◽  
Syncytial Virus

scholarly journals Epidemiologic, Experimental, and Clinical Links between Respiratory Syncytial Virus Infection and Asthma

2008 ◽  
Vol 21 (3) ◽  
pp. 495-504 ◽  
Author(s):  
Shyam S. Mohapatra ◽  
Sandhya Boyapalle
Keyword(s):  
Respiratory Syncytial Virus ◽  
Childhood Asthma ◽  
Molecular Mechanisms ◽  
Viral Infections ◽  
Severe Disease ◽  
Infection Process ◽  
Increased Risk ◽  
Rsv Infection ◽  
Recurrent Wheeze ◽  
Syncytial Virus

SUMMARY Virtually all children experience respiratory syncytial virus (RSV) infection at least once during the first 2 years of life, but only a few develop bronchiolitis and more severe disease requiring hospitalization, usually in the first 6 months of life. Children who recover from RSV-induced bronchiolitis are at increased risk for the development of recurrent wheeze and asthma in later childhood. Recent studies suggest that there is an association between RSV-induced bronchiolitis and asthma within the first decade of life but that this association is not significant after age 13. Despite the considerable progress made in our understanding of several aspects of respiratory viral infections, further work needs to be done to clarify the molecular mechanisms of early interactions between virus and host cell and the role of host gene products in the infection process. This review provides a critical appraisal of the literature in epidemiology and experimental research which links RSV infection to asthma. Studies to date demonstrate that there is a significant association between RSV infection and childhood asthma and that preventing severe primary RSV infections can decrease the risk of childhood asthma.

scholarly journals Respiratory syncytial virus immunoprophylaxis in high-risk infants and development of childhood asthma

2017 ◽  
Vol 139 (1) ◽  
pp. 66-71.e3 ◽  
Author(s):  
Kecia N. Carroll ◽  
Tebeb Gebretsadik ◽  
Gabriel J. Escobar ◽  
Pingsheng Wu ◽  
Sherian Xu Li ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
High Risk ◽  
Childhood Asthma ◽  
Syncytial Virus ◽  
High Risk Infants

CEACAM3 decreases asthma exacerbations and modulates respiratory syncytial virus latent infection in children

Thorax ◽  
2020 ◽  
Vol 75 (9) ◽  
pp. 725-734
Author(s):  
Ching-Hui Tsai ◽  
Ann Chen Wu ◽  
Bor-Luen Chiang ◽  
Yao-Hsu Yang ◽  
Shih-Pin Hung ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Mrna Expression ◽  
Childhood Asthma ◽  
Latent Infection ◽  
Meta Analysis ◽  
Asthma Management ◽  
Management Program ◽  
Nucleotide Polymorphisms ◽  
Asthma Exacerbations ◽  
Syncytial Virus

BackgroundRespiratory syncytial virus (RSV) is associated with childhood asthma. Nevertheless, not all children exposed to RSV develop asthma symptoms, possibly because genes modulate the effects of RSV on asthma exacerbations.ObjectiveThe purpose of this study was to identify genes that modulate the effect of RSV latent infection on asthma exacerbations.MethodsWe performed a meta-analysis to investigate differentially expressed genes (DEGs) of RSV infection from Gene Expression Omnibus datasets. Expression quantitative trait loci (eQTL) methods were applied to select single nucleotide polymorphisms (SNPs) that were associated with DEGs. Gene-based analysis was used to identify SNPs that were significantly associated with asthma exacerbations in the Taiwanese Consortium of Childhood Asthma Study (TCCAS), and validation was attempted in an independent cohort, the Childhood Asthma Management Program (CAMP). Gene–RSV interaction analyses were performed to investigate the association between the interaction of SNPs and RSV latent infection on asthma exacerbations.ResultsA total of 352 significant DEGs were found by meta-analysis of RSV-related genes. We used 38 123 SNPs related to DEGs to investigate the genetic main effects on asthma exacerbations. We found that eight RSV-related genes (GADD45A, GYPB, MS4A3, NFE2, RNASE3, EPB41L3, CEACAM6 and CEACAM3) were significantly associated with asthma exacerbations in TCCAS and also validated in CAMP. In TCCAS, rs7251960 (CEACAM3) significantly modulated the effect of RSV latent infection on asthma exacerbations (false-discovery rate <0.05). The rs7251960 variant was associated with CEACAM3 mRNA expression in lung tissue (p for trend=1.2×10−7). CEACAM3 mRNA was reduced in nasal mucosa from subjects with asthma exacerbations in two independent datasets.Conclusionsrs7251960 is an eQTL for CEACAM3, and CEACAM3 mRNA expression is reduced in subjects experiencing asthma exacerbations. CEACAM3 may be a modulator of RSV latent infection on asthma exacerbations.

The Association Between Respiratory Syncytial Virus Infection and the Development of Childhood Asthma

2007 ◽  
Vol 26 (8) ◽  
pp. 733-739 ◽  
Author(s):  
Eduardo G. P??rez-Yarza ◽  
Antonio Moreno ◽  
Pablo L??zaro ◽  
Asunci??n Mej??as ◽  
Octavio Ramilo
Keyword(s):  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Respiratory Syncytial Virus Infection ◽  
Childhood Asthma ◽  
Syncytial Virus

scholarly journals Risk of childhood asthma following infant bronchiolitis during the respiratory syncytial virus season

2013 ◽  
Vol 132 (1) ◽  
pp. 227-229 ◽  
Author(s):  
Kristina M. James ◽  
Tebeb Gebretsadik ◽  
Gabriel J. Escobar ◽  
Pingsheng Wu ◽  
Kecia N. Carroll ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Childhood Asthma ◽  
Respiratory Syncytial Virus Season ◽  
Syncytial Virus

scholarly journals Early-Life Respiratory Syncytial Virus Infection, Trained Immunity and Subsequent Pulmonary Diseases

Viruses ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 505 ◽  
Author(s):  
Carrie-Anne Malinczak ◽  
Nicholas W. Lukacs ◽  
Wendy Fonseca
Keyword(s):  
Immune System ◽  
Respiratory Syncytial Virus ◽  
Viral Infection ◽  
Childhood Asthma ◽  
Early Life ◽  
Pulmonary Diseases ◽  
Respiratory Viral Infection ◽  
Rsv Infection ◽  
Syncytial Virus

Respiratory syncytial virus (RSV) is often the first clinically relevant pathogen encountered in life, with nearly all children infected by two years of age. Many studies have also linked early-life severe respiratory viral infection with more pathogenic immune responses later in life that lead to pulmonary diseases like childhood asthma. This phenomenon is thought to occur through long-term immune system alterations following early-life respiratory viral infection and may include local responses such as unresolved inflammation and/or direct structural or developmental modifications within the lung. Furthermore, systemic responses that could impact the bone marrow progenitors may be a significant cause of long-term alterations, through inflammatory mediators and shifts in metabolic profiles. Among these alterations may be changes in transcriptional and epigenetic programs that drive persistent modifications throughout life, leaving the immune system poised toward pathogenic responses upon secondary insult. This review will focus on early-life severe RSV infection and long-term alterations. Understanding these mechanisms will not only lead to better treatment options to limit initial RSV infection severity but also protect against the development of childhood asthma linked to severe respiratory viral infections.

scholarly journals Integrated omics endotyping of infants with respiratory syncytial virus bronchiolitis and risk of childhood asthma

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yoshihiko Raita ◽  
Marcos Pérez-Losada ◽  
Robert J. Freishtat ◽  
Brennan Harmon ◽  
Jonathan M. Mansbach ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Childhood Asthma ◽  
Critical Period ◽  
Evidence Base ◽  
Species Level ◽  
Airway Microbiome ◽  
Integrated Omics ◽  
Syncytial Virus ◽  
Metabolome Data ◽  
High Risk Children

AbstractRespiratory syncytial virus (RSV) bronchiolitis is not only the leading cause of hospitalization in U.S. infants, but also a major risk factor for asthma development. While emerging evidence suggests clinical heterogeneity within RSV bronchiolitis, little is known about its biologically-distinct endotypes. Here, we integrated clinical, virus, airway microbiome (species-level), transcriptome, and metabolome data of 221 infants hospitalized with RSV bronchiolitis in a multicentre prospective cohort study. We identified four biologically- and clinically-meaningful endotypes: A) clinicalclassicmicrobiomeM. nonliquefaciensinflammationIFN-intermediate, B) clinicalatopicmicrobiomeS. pneumoniae/M. catarrhalisinflammationIFN-high, C) clinicalseveremicrobiomemixedinflammationIFN-low, and D) clinicalnon-atopicmicrobiomeM.catarrhalisinflammationIL-6. Particularly, compared with endotype A infants, endotype B infants—who are characterized by a high proportion of IgE sensitization and rhinovirus coinfection, S. pneumoniae/M. catarrhalis codominance, and high IFN-α and -γ response—had a significantly higher risk for developing asthma (9% vs. 38%; OR, 6.00: 95%CI, 2.08–21.9; P = 0.002). Our findings provide an evidence base for the early identification of high-risk children during a critical period of airway development.

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