Activated Naive CD4+Peripheral Blood T Cells in Autoimmune Thyroid Disease

Thyroid ◽  
1995 ◽  
Vol 5 (2) ◽  
pp. 117-123 ◽  
Author(s):  
ALOIS GESSL ◽  
ASTRID WILFING ◽  
HERMINE AGIS ◽  
GEORG STEINER ◽  
SOPHIA CZERNIN ◽  
...  
Keyword(s):  
T Cells ◽  
Peripheral Blood ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid

scholarly journals The proportion of peripheral blood Tregs among the CD4+ T cells of autoimmune thyroid disease patients: a meta-analysis

2020 ◽  
Vol 67 (3) ◽  
pp. 317-326 ◽  
Author(s):  
Ziyi Chen ◽  
Yue Wang ◽  
Xi Ding ◽  
Meng Zhang ◽  
Mingqian He ◽  
...  
Keyword(s):  
T Cells ◽  
Peripheral Blood ◽  
Thyroid Disease ◽  
Cd4 T Cells ◽  
Autoimmune Thyroid Disease ◽  
Meta Analysis ◽  
Autoimmune Thyroid

scholarly journals PD-1/PD-L1 Expressions on Treg Cells in Patients with Autoimmune Thyroid Disease

2021 ◽  
Author(s):  
Lin Cui ◽  
Xiaotong Gu ◽  
Haixia Liu ◽  
Hong Zheng
Keyword(s):  
T Cells ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Peripheral Blood ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Treg Cells ◽  
Graves Disease ◽  
Newly Diagnosed ◽  
Autoimmune Thyroid

Abstract Background: Autoimmune thyroid disease(AITD) is a frequent autoimmune disease characterized by lymphocytic infiltration and thyroid autoantibody production caused by autoimmune dysfunction. Recent studies have shown that Treg cells can participate in the pathogenesis of AITD by inhibiting peripheral reactive T cells and thereby inhibiting the autoimmune responses. Programmed cell death-1 (PD-1)/programmed cell death ligand (PD-L1) pathway is a negative costimulatory pathway discovered in recent years, enhancing or blocking this pathway is associated with the immune process of AITD. PD-1/PD-L1 was simultaneously expressed on Treg cells. In this paper, the role of regulatory T cells and PD-1/PD-L1 signaling pathway in AITD was discussed.Methods: We detected the percentage of CD4+CD25+CD127lowT cells, the ratio of PD-1+Treg cells and PD-L1+Treg cells in peripheral blood of twenty patients newly diagnosed with graves disease (GD) and twenty-one patients newly diagnosed with Hashimotos’thyroiditis (HT) patients by flow cytometry, and samples from twenty healthy individuals served as control.Results: The results demonstrated that the proportion of CD4+CD25+CD127lowT cells in peripheral blood of HT patients was lower than that of healthy controls(HCs), the ratio of PD-1+Treg cells of HT patients was higher than that of the HCs and GD patients, the ratio of PD-1+Treg cells of GD patients was higher than that of the HCs, the ratio of PD-L1+Treg cells in Treg cells of HT patients was higher than that of the HCs and GD patients and the ratio of PD-L1+Treg cells of GD patients was higher than that of the HCs. All the above were statistically significant.Conclusions: The treg cells play an obvious role in hashimoto's thyroiditis, but not obvious in Graves' disease.

Activation and Suppression of T Cells in Response to Thyroid and Fat Cell Membranes in Patients with Autoimmune Thyroid Disease

1985 ◽  
Vol 69 (s12) ◽  
pp. 23P-23P
Author(s):  
C.J. O'Brien ◽  
S. Vento ◽  
T. Cundy ◽  
C. MacSorley ◽  
A.L.W.F. Eddleston ◽  
...  
Keyword(s):  
T Cells ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Cell Membranes ◽  
Fat Cell ◽  
Autoimmune Thyroid

Evidence of Limited Variability of Antigen Receptors on Intrathyroidal T Cells in Autoimmune Thyroid Disease

1991 ◽  
Vol 325 (4) ◽  
pp. 238-244 ◽  
Author(s):  
Terry F. Davies ◽  
Andreas Martin ◽  
Erlinda S. Concepcion ◽  
Peter Graves ◽  
Lydia Cohen ◽  
...  
Keyword(s):  
T Cells ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Antigen Receptors ◽  
Autoimmune Thyroid

Proliferative responses of T-cells to thyroid antigens and synthetic thyroid peroxidase peptides in autoimmune thyroid disease.

1995 ◽  
Vol 80 (5) ◽  
pp. 1597-1604 ◽  
Author(s):  
M E Fisfalen ◽  
M Soliman ◽  
Y Okamoto ◽  
K Soltani ◽  
L J DeGroot
Keyword(s):  
T Cells ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Peroxidase ◽  
Autoimmune Thyroid

Increases of CD80 and CD86 Expression on Peripheral Blood Cells and their Gene Polymorphisms in Autoimmune Thyroid Disease

2019 ◽  
Vol 49 (1-2) ◽  
pp. 191-203 ◽  
Author(s):  
Ayano Watanabe ◽  
Naoya Inoue ◽  
Mikio Watanabe ◽  
Mayu Yamamoto ◽  
Haruka Ozaki ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Thyroid Disease ◽  
Blood Cells ◽  
Gene Polymorphisms ◽  
Autoimmune Thyroid Disease ◽  
Peripheral Blood Cells ◽  
Autoimmune Thyroid

Association of IL-10-Regulating MicroRNAs in Peripheral Blood Mononuclear Cells with the Pathogenesis of Autoimmune Thyroid Disease

2017 ◽  
Vol 46 (6) ◽  
pp. 590-602 ◽  
Author(s):  
Yukina Takuse ◽  
Mikio Watanabe ◽  
Naoya Inoue ◽  
Ritsuko Ozaki ◽  
Hiroshi Ohtsu ◽  
...  
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Mononuclear Cells ◽  
Peripheral Blood Mononuclear ◽  
Autoimmune Thyroid ◽  
Blood Mononuclear Cells

T Cells and Human Autoimmune Thyroid Disease: Emerging Data Show Lack of Need to Invoke Suppressor T Cell Problems

Thyroid ◽  
1992 ◽  
Vol 2 (3) ◽  
pp. 247-261 ◽  
Author(s):  
ANDREAS MARTIN ◽  
TERRY F. DAVIES
Keyword(s):  
T Cells ◽  
T Cell ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Autoimmune Thyroid ◽  
Suppressor T Cell
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