<b>Familial risk of Hashimoto’s thyroiditis among first degree relatives, a population-based study in Korea </b>

ObjectiveTo investigate the relation of Hashimoto’s thyroiditis (HT) to cholelithiasis and cholecystectomy in a retrospective population-based study.SettingCohort study.ParticipantsWe identified 1268 patients aged ≥20 years with HT between 2000 and 2010 as the study cohort.Primary and secondary outcome measuresPatients without HT were randomly selected from a database and propensity-matched with the study cohort at a 1:4 ratio according to age, sex, comorbidities and year of the index date to measure the incidence of cholelithiasis and cholecystectomy.ResultsThe cumulative incidence of cholelithiasis was higher in the HT cohort than that in the non-HT cohort (log-rank test, p<0.001), with a 1.91-fold higher risk of choleithiasis (95% CI 1.58 to 2.33) after adjustment for comorbidities. The age-specific relative risk of cholelithiasis in the HT cohort was higher than that in the non-HT cohort for patients aged ≥50 years (adjusted HR (aHR)=2.59, 95% CI 1.33 to 5.03). The sex-specific relative risk of cholelithiasis in the HT cohort was higher than that in the non-HT cohort for women (aHR=1.99, 95% CI 1.63 to 2.44). Compared with those in the non-HT cohort, patients with HT without (aHR=1.95, 95% CI 1.53 to 2.49) and with (aHR=1.94, 95% CI 1.51 to 2.49) thyroxine treatment were associated with a higher risk of cholelithiasis. Compared with those in the non-HT cohort, patients with HT had a higher risk of cholecystectomy (aHR=1.28, 95% CI 1.02 to 1.61).ConclusionsInability to obtain information on several potential confounding factors and misclassification of important covariates are the major limitations of the study. Our study indicates HT per se was associated with the development of cholelithiasis, which has been validated by the association between cholecystectomy and HT. Surveys and health education on cholelithiasis in women aged ≥50 years with HT should be considered by clinicians, and further prospective research should be done on this topic.

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Limited Genetic Overlap Between Hashimoto's Thyroiditis and Graves' Disease: A Population-Based Twin Study

Clinical Thyroidology ◽

10.1089/ct.2021;33.299-301 ◽

2021 ◽

Vol 33 (7) ◽

pp. 299-301

Author(s):

Eijun Nishihara ◽

Takashi Akamizu ◽

Akira Miyauchi

Keyword(s):

Twin Study ◽

Hashimoto’S Thyroiditis ◽

Population Based ◽

Hashimoto's Thyroiditis ◽

Graves Disease ◽

Genetic Overlap

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The making and unmaking of Hashimoto’s thyroiditis: On the mismatch between illness and disease. Results from an Italian study

Health An Interdisciplinary Journal for the Social Study of Health Illness and Medicine ◽

10.1177/13634593211048370 ◽

2021 ◽

pp. 136345932110483

Author(s):

Mario Cardano ◽

Eleonora Rossero

Keyword(s):

Hashimoto’S Thyroiditis ◽

Scientific Evidence ◽

Systems Design ◽

Population Based ◽

Hashimoto's Thyroiditis ◽

Diagnostic Process ◽

Subjective Experiences ◽

Ideal Types ◽

Hierarchy Of Evidence ◽

Illness And Disease

The diagnostic process in contemporary medical practice is increasingly technical, specialised and relying on population-based ranges of biological normalcy. Disease is defined according to a hierarchy of evidence that privileges specialist knowledge and marginalises subjective experiences of illness. Medical and individual definitions of the situation can conflict in two ways: (i) a diagnosis is made in the absence of symptoms, (ii) individual suffering does not constitute ‘real’ disease if it is not validated by scientific evidence. This article investigates how the discrepancy between specialist and embodied knowledge is experienced and tentatively solved by patients’ self-narratives. Starting from the analysis of 22 in-depth interviews with people affected by autoimmune diseases, we focus on the subgroup affected by Hashimoto’s thyroiditis. Applying the most-different-systems design, we confront two flesh-and-blood ideal-types of illness narratives characterised by a mismatch between illness and disease. Their diagnostic trajectories are outlined and discussed as poles of a continuum of experiences resulting from different configurations of medical evidence of disease and subjective evidence of illness.

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54 P Helicobacter pylori (HP) infection and risk of intestinal metaplasia in first-degree relatives of gastric cancer patients: A population based study

Digestive and Liver Disease ◽

10.1016/s1590-8658(02)90093-9 ◽

2002 ◽

Vol 34 ◽

pp. A24

Author(s):

M.R. Zagari ◽

S. Casanova ◽

R. Fiocca ◽

P. Pozzato ◽

C. Martuzzi ◽

...

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Intestinal Metaplasia ◽

Cancer Patients ◽

Population Based ◽

Population Based Study ◽

First Degree Relatives ◽

Gastric Cancer Patients

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A population-wide analysis of the familial risk of suicide in Utah, USA

Psychological Medicine ◽

10.1017/s0033291721003020 ◽

2021 ◽

pp. 1-10

Author(s):

Amanda V. Bakian ◽

Danli Chen ◽

Chong Zhang ◽

Heidi A. Hanson ◽

Anna R. Docherty ◽

...

Keyword(s):

Suicide Risk ◽

Cox Regression ◽

Familial Risk ◽

Risk Groups ◽

Population Based ◽

Unified Framework ◽

Population Database ◽

First Degree Relatives ◽

Hazard Ratios ◽

History Of

Abstract Background The degree to which suicide risk aggregates in US families is unknown. The authors aimed to determine the familial risk of suicide in Utah, and tested whether familial risk varies based on the characteristics of the suicides and their relatives. Methods A population-based sample of 12 160 suicides from 1904 to 2014 were identified from the Utah Population Database and matched 1:5 to controls based on sex and age using at-risk sampling. All first through third- and fifth-degree relatives of suicide probands and controls were identified (N = 13 480 122). The familial risk of suicide was estimated based on hazard ratios (HR) from an unsupervised Cox regression model in a unified framework. Moderation by sex of the proband or relative and age of the proband at time of suicide (<25 v. ⩾25 years) was examined. Results Significantly elevated HRs were observed in first- (HR 3.45; 95% CI 3.12–3.82) through fifth-degree relatives (HR 1.07; 95% CI 1.02–1.12) of suicide probands. Among first-degree relatives of female suicide probands, the HR of suicide was 6.99 (95% CI 3.99–12.25) in mothers, 6.39 in sisters (95% CI 3.78–10.82), and 5.65 (95% CI 3.38–9.44) in daughters. The HR in first-degree relatives of suicide probands under 25 years at death was 4.29 (95% CI 3.49–5.26). Conclusions Elevated familial suicide risk in relatives of female and younger suicide probands suggests that there are unique risk groups to which prevention efforts should be directed – namely suicidal young adults and women with a strong family history of suicide.

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