CRF
Chapter 5 explains how excessive fear is tied to anxiety disorders, and vulnerability to the breakdown of mental and physical health. CRF in the brain is tied to these events. CRF, for instance, may be constrained by the neurotransmitter GABA in key regions of the forebrain and is mobilized by brainstem catecholaminergic neurons that are critical in coping with and adapting to everyday life; and of course, one is less able to do so when these information molecules are compromised by genetic predispositions and social duress. One hypothesis about CRF and the brain is that at least two forebrain sites are differentially involved in regulating both adaptive fear and deleterious chronic anxiety. There are great varieties of events that can cause fear in individuals: anything from downsizing at work to acts of terrorism and crime.