scholarly journals Fetal programming in ruminant animals: understanding skeletal muscle development to improve meat quality

2021 ◽  
Vol 11 (6) ◽  
pp. 5-6
Keyword(s):  
Skeletal Muscle ◽  
Meat Quality ◽  
Fetal Programming ◽  
Muscle Development ◽  
Skeletal Muscle Development ◽  
Ruminant Animals

scholarly journals Fetal programming in ruminant animals: understanding the skeletal muscle development to improve meat quality

2021 ◽  
Vol 11 (6) ◽  
pp. 66-73 ◽  
Author(s):  
Thaís Correia Costa ◽  
Mateus Pies Gionbelli ◽  
Marcio de Souza Duarte
Keyword(s):  
Skeletal Muscle ◽  
Meat Quality ◽  
Fetal Programming ◽  
Muscle Development ◽  
Skeletal Muscle Development ◽  
Ruminant Animals

scholarly journals Key Genes Regulating Skeletal Muscle Development and Growth in Farm Animals

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 835
Author(s):  
Mohammadreza Mohammadabadi ◽  
Farhad Bordbar ◽  
Just Jensen ◽  
Min Du ◽  
Wei Guo
Keyword(s):  
Skeletal Muscle ◽  
Candidate Genes ◽  
Meat Quality ◽  
Muscle Development ◽  
Muscle Growth ◽  
Farm Animals ◽  
Meat Production ◽  
Skeletal Muscle Development ◽  
Extrinsic Factors ◽  
Myogenic Regulatory Factor

Farm-animal species play crucial roles in satisfying demands for meat on a global scale, and they are genetically being developed to enhance the efficiency of meat production. In particular, one of the important breeders’ aims is to increase skeletal muscle growth in farm animals. The enhancement of muscle development and growth is crucial to meet consumers’ demands regarding meat quality. Fetal skeletal muscle development involves myogenesis (with myoblast proliferation, differentiation, and fusion), fibrogenesis, and adipogenesis. Typically, myogenesis is regulated by a convoluted network of intrinsic and extrinsic factors monitored by myogenic regulatory factor genes in two or three phases, as well as genes that code for kinases. Marker-assisted selection relies on candidate genes related positively or negatively to muscle development and can be a strong supplement to classical selection strategies in farm animals. This comprehensive review covers important (candidate) genes that regulate muscle development and growth in farm animals (cattle, sheep, chicken, and pig). The identification of these genes is an important step toward the goal of increasing meat yields and improves meat quality.

Fetal programming of skeletal muscle development in ruminant animals1

2010 ◽  
Vol 88 (suppl_13) ◽  
pp. E51-E60 ◽  
Author(s):  
M. Du ◽  
J. Tong ◽  
J. Zhao ◽  
K. R. Underwood ◽  
M. Zhu ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Fetal Programming ◽  
Muscle Development ◽  
Skeletal Muscle Development

scholarly journals Effects and Molecular Mechanism of Single-Nucleotide Polymorphisms of MEG3 on Porcine Skeletal Muscle Development

2021 ◽  
Vol 12 ◽  
Author(s):  
Rui Yang ◽  
Yinuo Liu ◽  
Yunyun Cheng ◽  
Chunli Wang ◽  
Jie Song ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Western Blot ◽  
Meat Quality ◽  
Muscle Development ◽  
Cell Counting ◽  
Nucleotide Polymorphisms ◽  
Skeletal Muscle Development ◽  
Western Blot Assay ◽  
Single Nucleotide ◽  
The Stability

Maternally expressed gene 3 (MEG3) is a long non-coding RNA that is a crucial regulator of skeletal muscle development. Some single-nucleotide polymorphism (SNP) mutants in MEG3 had strong associations with meat quality traits. Nevertheless, the function and mechanism of MEG3 mutants on porcine skeletal muscle development have not yet been well-demonstrated. In this study, eight SNPs were identified in MEG3 of fat- and lean-type pig breeds. Four of these SNPs (g.3087C > T, g.3108C > T, g.3398C > T, and g.3971A > C) were significantly associated with meat quality and consisted of the CCCA haplotype for fat-type pigs and the TTCC haplotype for lean-type pigs. Quantitative real-time PCR results showed that the expression of MEG3-TTCC was higher than that of MEG3-CCCA in transcription level (P < 0.01). The stability assay showed that the lncRNA stability of MEG3-TTCC was lower than that of MEG3-CCCA (P < 0.05). Furthermore, the results of qRT-PCR, Western blot, and Cell Counting Kit-8 assays demonstrated that the overexpression of MEG3-TTCC more significantly inhibited the proliferation of porcine skeletal muscle satellite cells (SCs) than that of MEG3-CCCA (P < 0.05). Moreover, the overexpression of MEG3-TTCC more significantly promoted the differentiation of SCs than that of MEG3-CCCA (P < 0.05). The Western blot assay suggested that the overexpression of MEG3-TTCC and MEG3-CCCA inhibited the proliferation of SCs by inhibiting PI3K/AKT and MAPK/ERK1/2 signaling pathways. The overexpression of the two haplotypes also promoted the differentiation of SCs by activating the JAK2/STAT3 signaling pathway in different degrees. These data are valuable for further studies on understanding the crucial role of lncRNAs in skeletal muscle development.

Plectin regulates Wnt signaling mediated-skeletal muscle development by interacting with Dishevelled-2 and antagonizing autophagy

Gene ◽  
2021 ◽  
Vol 783 ◽  
pp. 145562
Author(s):  
Huadong Yin ◽  
Shunshun Han ◽  
Can Cui ◽  
Yan Wang ◽  
Diyan Li ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Wnt Signaling ◽  
Muscle Development ◽  
Skeletal Muscle Development

scholarly journals Depletion of the p43 mitochondrial T3 receptor in mice affects skeletal muscle development and activity

2011 ◽  
Vol 26 (2) ◽  
pp. 748-756 ◽  
Author(s):  
Laurence Pessemesse ◽  
Audrey Schlernitzauer ◽  
Chamroeun Sar ◽  
Jonathan Levin ◽  
Stéphanie Grandemange ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Development ◽  
Skeletal Muscle Development
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