Delayed expulsion of the nematode Nippostrongylus brasiliensis from rats on a low protein diet: the role of a bone marrow derived component

1981 ◽  
Vol 34 (3) ◽  
pp. 400-403 ◽  
Author(s):  
V M Duncombe ◽  
T D Bolin ◽  
A E Davis ◽  
J D Kelly
Keyword(s):  
Bone Marrow ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Nippostrongylus Brasiliensis ◽  
Low Protein

scholarly journals The Effect of Ketoanalogues on Chronic Kidney Disease Deterioration: A Meta-Analysis

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 957 ◽  
Author(s):  
Albert Li ◽  
Hsiang-Yen Lee ◽  
Yen-Chung Lin
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Meta Analysis ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein ◽  
Randomized Control ◽  
Very Low Protein Diet ◽  
Restricted Protein Diet

The effects of ketoanalogues (KA) on chronic kidney disease (CKD) deterioration have not yet been fully confirmed. To strengthen the evidence of the role of KA in CKD, PubMed and Embase were searched for studies published through February 2019. Effect sizes from ten randomized control trials (RCTs) and two non-RCTs comprising a total of 951 patients were pooled and analyzed. A restricted protein diet supplemented with ketoanalogues (RPKA) was found to significantly delay the progression of CKD (p = 0.008), particularly in patients with an estimated glomerular filtration rate (eGFR) > 18 mL/min/1.73 m2 (p < 0.0001). No significant change in eGFR was found when comparing a very-low-protein diet and a low-protein diet (p = 0.10). In addition, compared with the placebo, RPKA did not cause malnutrition (albumin: p = 0.56; cholesterol: p = 0.50). Moreover, RPKA significantly decreased phosphorous levels (p = 0.001), increased calcium levels (p = 0.04), and decreased parathyroid hormone (PTH) levels (p = 0.05) in patients with eGFR < 18 mL/min/1.73 m2. In conclusion, RPKA could slow down the progression of CKD in patients with eGFR > 18 mL/min/1.73 m2 without causing malnutrition and reverse CKD-MBD in patients with eGFR < 18 mL/min/1.73 m2.

scholarly journals Liver GCN2 controls hepatic FGF21 secretion and modulates whole body postprandial oxidation profile under a low-protein diet

2019 ◽  
Vol 317 (6) ◽  
pp. E1015-E1021 ◽  
Author(s):  
Tristan Chalvon-Demersay ◽  
Joanna Moro ◽  
Patrick C. Even ◽  
Catherine Chaumontet ◽  
Daniel Tomé ◽  
...  
Keyword(s):  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Whole Body ◽  
Low Protein ◽  
The One ◽  
High Level ◽  
High Protein Diets

General control nonderepressible 2 (GCN2) is a kinase that detects amino acid deficiency and is involved in the control of protein synthesis and energy metabolism. However, the role of hepatic GCN2 in the metabolic adaptations in response to the modulation of dietary protein has been seldom studied. Wild-type (WT) and liver GCN2-deficient (KO) mice were fed either a normo-protein diet, a low-protein diet, or a high-protein diet for 3 wk. During this period, body weight, food intake, and metabolic parameters were followed. In mice fed normo- and high-protein diets, GCN2 pathway in the liver is not activated in WT mice, leading to a similar metabolic profile with the one of KO mice. On the contrary, a low-protein diet activates GCN2 in WT mice, inducing FGF21 secretion. In turn, FGF21 maintains a high level of lipid oxidation, leading to a different postprandial oxidation profile compared with KO mice. Hepatic GCN2 controls FGF21 secretion under a low-protein diet and modulates a whole body postprandial oxidation profile.

scholarly journals The role of maternal low protein diet on neural stem cells and neurogenesis in the offspring brain?

2014 ◽  
Author(s):  
Chris J Airey ◽  
Phoebe J Smith ◽  
Joanna M Gould ◽  
Stephanie J Marfy-Smith ◽  
Tom P Fleming ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein

scholarly journals The Role of Low Protein Diet (LPD) in the Treatment of Chronic Kidney Disease (CKD)

2003 ◽  
Vol 51 (6) ◽  
pp. 928-932 ◽  
Author(s):  
Tatsuo SHIIGAI ◽  
Yoshitaka MAEDA ◽  
Takahiko KOBAYASHI ◽  
Takehito TANASE ◽  
Kimie KOBAYASHI
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein

Protein losing enteropathy associated with Nippostrongylus brasiliensis infestation and its impact on albumin homoeostasis in rats fed two levels of dietary protein

1986 ◽  
Vol 70 (5) ◽  
pp. 469-475 ◽  
Author(s):  
P. G. Lunn ◽  
C. A. Northrop ◽  
R. H. Behrens ◽  
J. Martin ◽  
M. Wainwright
Keyword(s):  
Protein Diet ◽  
Low Protein Diet ◽  
Albumin Concentration ◽  
Nippostrongylus Brasiliensis ◽  
Protein Loss ◽  
Plasma Albumin ◽  
Protein Food ◽  
Protein Losing Enteropathy ◽  
Low Protein ◽  
Plasma Albumin Concentration

1. Alterations in plasma albumin concentration and gastrointestinal permeability have been investigated in rats infected with the nematode Nippostrongylus brasiliensis and fed adequate or low protein diets. 2. Infection caused only minor changes in growth and food consumption of well nourished rats but resulted in significant reductions in those fed the low protein diet. 3. Animals in both dietary groups were able to mount an immune response beyond day 10 postinfection (p.i.) which caused expulsion of the parasites, but this was less effective in rats fed the low protein food. 4. Uninfected rats fed the low protein diet had significantly lower plasma albumin concentrations than their well nourished counterparts. Animals of both dietary groups showed a progressive reduction in plasma albumin concentration as the infection developed but values returned towards normal as the parasites were expelled. 5. The reduction in plasma albumin concentration was closely associated with increases in gastrointestinal leakage of plasma protein but losses were far greater in the protein deficiency animals. Beyond day 10 p.i. protein loss decreased in both dietary groups and by day 21 p.i. had returned to normal in well nourished animals but not those fed the low protein diet. 6. Intestinal permeability measured by the lactulose:mannitol ratio technique gave similar results to the protein loss data. Permeability increased as the infection progressed then fell as the worms were expelled but remained above control values in infected protein deficient animals. 7. Overall, animals fed the low protein diet were more severely affected by the parasite than were their well fed counterparts. The data clearly demonstrated that the combined effects of infection and dietary deficiency resulted in a more severe reduction in plasma albumin values than either factor produced alone. The results are discussed with reference to the aetiology of hypoalbuminaemia and kwashiorkor in man.

Scanning electron microscope studies of the small intestine of rats maintained on a low protein diet and infected with Nippostrongylus brasiliensis

Parasitology ◽  
1980 ◽  
Vol 80 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Jean Martin
Keyword(s):  
Small Intestine ◽  
Electron Microscope ◽  
Scanning Electron Microscope ◽  
Morphological Changes ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Nippostrongylus Brasiliensis ◽  
Blood Constituents ◽  
Low Protein ◽  
Scanning Electron

SummaryIn undernourished rats infected with Nippostrongylus brasiliensis partial villus atrophy was observed in large areas of the anterior and posterior regions of the intestine. In addition, the following changes in structure were observed; some areas of the intestine contained misshapen villi which lacked microvilli on the lateral surfaces; cell-like bodies devoid of microvilli appeared to be budded off from the sides and tips of some malformed villi and there appeared to be extensive leakage of blood constituents into the lumen of the intestine. Morphological changes were present up to day 24 of the infection when the experiment was terminated. The possible consequences of the extensive breakdown of villus structure are discussed.

The role of once-weekly online hemodiafiltration with low protein diet for initiation of renal replacement therapy: A case series

2021 ◽  
pp. 039139882110498
Author(s):  
Kullaya Takkavatakarn ◽  
Piyawan Kittiskulnam ◽  
Khajohn Tiranathanagul ◽  
Pisut Katavetin ◽  
Niramon Wongyai ◽  
...  
Keyword(s):  
Urine Volume ◽  
Case Series ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein ◽  
Incremental Hemodialysis ◽  
Clinical Benefits ◽  
The Mean ◽  
The University

Incremental hemodialysis (HD) has become an exciting approach according to the recognition of the importance of preserving residual kidney function (RKF). However, not all incident HD patients are suitable for this approach, particularly once-weekly HD. This is the first study which reported the effectiveness of once-weekly online-hemodiafiltration (OL-HDF) plus low protein diet (LPD) in incident HD patients. All stage 5 CKD patients who had chosen HD as their treatment modality at the HD center of King Chulalongkorn Memorial Hospital, Bangkok, Thailand, with RKF ⩾ 3 mL/min calculated by renal clearance of urea and urine output ⩾ 800 mL/day, started the treatment with once-weekly OL-HDF. Dietitians advised patients to consume LPD (0.6–0.8 g/kg/day) on non-dialysis days and a regular protein diet on the dialysis day (1.2 g/kg/day). Eleven incident HD patients were enrolled in the study. The mean RKF and urine volume at baseline were 4.56 ± 2.21 mL/min and 2,019.54 ± 743.73 mL/day, respectively. After 6 and 12 months of follow-up, the mean RKF of the patients who remained in the once-weekly OL-HDF protocol were 3.82 ± 1.68 mL/min and 3.28 ± 0.95 mL/min, respectively. The median duration of once-weekly OL-HDF before transitioning to twice- or thrice-weekly OL-HDF was 7 months (3–24 months). The most common indication for stepping prescription was too low RKF. We reported that dialysis initiation in the university-based center with once-weekly OL-HDF in carefully selected incident HD patients combined with LPD under serial monitoring is practical. Further studies on the clinical benefits of once-weekly OL-HDF are still required.

Sign in / Sign up

Export Citation Format

Share Document