Weight loss and 2-y follow-up for 80 morbidly obese patients treated with intensive very-low-calorie diet and an education program

1992 ◽  
Vol 56 (1) ◽  
pp. 244S-246S ◽  
Author(s):  
J W Anderson ◽  
V L Brinkman ◽  
C C Hamilton
Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4468
Author(s):  
Ivan Ožvald ◽  
Dragan Božičević ◽  
Lidija Duh ◽  
Ivana Vinković Vrček ◽  
Ivan Pavičić ◽  
...  

Although a very-low-calorie diet (VLCD) is considered safe and has demonstrated benefits among other types of diets, data are scarce concerning its effects on improving health and weight loss in severely obese patients. As part of the personalized weight loss program developed at the Duga Resa Special Hospital for Extended Treatment, Croatia, we evaluated anthropometric, biochemical, and permanent DNA damage parameters (assessed with the cytochalasin B-blocked micronucleus cytome assay—CBMN) in severely obese patients (BMI ≥ 35 kg m−2) after 3-weeks on a 567 kcal, hospital-controlled VLCD. This is the first study on the permanent genomic (in)stability in such VLCD patients. VLCDs caused significant decreases in weight (loss), parameters of the lipid profile, urea, insulin resistance, and reduced glutathione (GSH). Genomic instability parameters were lowered by half, reaching reference values usually found in the healthy population. A correlation was found between GSH decrease and reduced DNA damage. VLCDs revealed susceptible individuals with remaining higher DNA damage for further monitoring. In a highly heterogeneous group (class II and III in obesity, differences in weight, BMI, and other categories) consisting of 26 obese patients, the approach demonstrated its usefulness and benefits in health improvement, enabling an individual approach to further monitoring, diagnosis, treatment, and risk assessment based on changing anthropometric/biochemical VLCD parameters, and CBMN results.


2013 ◽  
Vol 23 (10) ◽  
pp. 1624-1631 ◽  
Author(s):  
Jordán González-Pérez ◽  
Sofía Sánchez-Leenheer ◽  
Alfredo Rivas Delgado ◽  
Lizbeth González-Vargas ◽  
Mariana Díaz-Zamudio ◽  
...  

2009 ◽  
Vol 4 (2) ◽  
pp. 54
Author(s):  
M.D. Ballesteros-Pomar ◽  
R. Diez Rodriguez ◽  
A. Calleja-Fernández ◽  
A.M. Urioste-Fondo ◽  
A. Vidal-Casariego ◽  
...  

2012 ◽  
Vol 95 (3) ◽  
pp. 609-613 ◽  
Author(s):  
Ilaria Malandrucco ◽  
Patrizio Pasqualetti ◽  
Ilaria Giordani ◽  
Dario Manfellotto ◽  
Federica De Marco ◽  
...  

2018 ◽  
Vol 29 (1) ◽  
pp. 54-60 ◽  
Author(s):  
Kamthorn Yolsuriyanwong ◽  
Komdej Thanavachirasin ◽  
Kimberly Sasso ◽  
Lauren Zuro ◽  
Jessica Bartfield ◽  
...  

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