Short-term overfeeding increases resting energy expenditure in patients with HIV lipodystrophy

Objective:The objective of this study was to describe changes in the resting energy expenditure, substrate oxidation rate, and body composition in morbidly obese women subjected to short-term caloric restriction. Methods:This was a prospective study that included ten obese women with body mass index greater than 40 kg/m2 and aged between 20-50 years. The participants were hospitalized for eight days and received a controlled conventional low-calorie diet, 1200 kcal/day, for seven days. Body weight, body mass index, abdominal circumference, body composition, resting energy expenditure, and substrate oxidation rate were evaluated at the beginning and at the end of the study. Results:A significant reduction in body weight (p=0.005), body mass index (p=0.005), abdominal circumference (p=0.005), fat mass (p=0.005) and fat-free mass (p=0.008) was observed at the end of the study. There was an average reduction in resting energy expenditure of approximately 124 kcal/day (5%). Substrate oxidation rate did not show statistically significant changes. There was a positive correlation only between body weight reduction and fat-free mass reduction (r=0.753; p=0.012). Conclusion:There was an adaptive response of the resting energy expenditure with short-term energy restriction in morbidly obese women with a 5% reduction in resting energy expenditure and a positive correlation between weight loss and the fat-free mass, which indicates the influence of fat-free mass on the decrease in resting energy expenditure. Therefore, short-term caloric restriction in morbidly obese women led to a decrease in resting energy expenditure and fat-free mass, which suggests a rapid adaptation of energy expenditure.

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Persistently Increased Resting Energy Expenditure Predicts Short-Term Mortality in Patients with Acute-on-Chronic Liver Failure

Annals of Nutrition and Metabolism ◽

10.1159/000487604 ◽

2018 ◽

Vol 73 (1) ◽

pp. 2-9

Author(s):

Jia Yao ◽

Xiaoshuang Zhou ◽

Hui Wang ◽

Lili Yuan ◽

Yu Chen ◽

...

Keyword(s):

Liver Disease ◽

Hepatitis B ◽

Energy Expenditure ◽

Liver Failure ◽

Resting Energy Expenditure ◽

Chronic Liver ◽

Chronic Liver Failure ◽

Short Term ◽

Short Term Mortality ◽

Resting Energy

Objective: Hypermetabolism based on measurements of resting energy expenditure (REE) is suggested to be a potential biomarker for predicting the clinical outcomes of some diseases. We aimed to evaluate the potential value of hypermetabolism for predicting the short-term (28-day) mortality of patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). Methods: A total of 105 HBV-ACLF patients, 30 chronic hepatitis B (CHB) patients and 30 healthy controls (HCs) were included in this study. The REE was measured using indirect calorimetry in the morning after 8–10 h of fasting. The predicted REE (REEHB) was determined using Harris-Benedict equation. Persistent hypermetabolism was defined as the REE:REEHB ratio > 1.20 at day 1 and day 7 after admission. The severity of liver disease was estimated using the Model for End-Stage Liver Disease (MELD). Clinical and biochemical variables were determined using blood samples ordered upon admission. These variables were compared between nonsurviving and surviving patients who were classified according to the 28-day mortality. Results: The frequency of hypermetabolism at baseline was significantly higher in ACLF patients than that in HCs and CHB patients. Forty-six (43.8%) ACLF patients died within follow-up of 28 days. Persistent hypermetabolism (OR 2.10; 95% CI 1.15–3.69; p = 0.002) and MELD score (OR 1.93; 95% CI 1.47–3.51; p = 0.012) were independent predictive indicators of 28-day mortality. Furthermore, the performance of the 2 variables (persistent hypermetabolism and MELD) together with the area under the receiver operating curve (AUROC: 0.819) was significantly better than that of MELD alone (AUROC: 0.694) for prediction of short-term mortality (p = 0.014). Conclusion: These findings indicate that persistent hypermetabolism is predictive of short-term mortality in this small population.

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The Short-term Effect of a Balanced Deficit Diet on Resting Energy Expenditure.

Medicine & Science in Sports & Exercise ◽

10.1249/01.mss.0000273112.80469.aa ◽

2007 ◽

Vol 39 (Supplement) ◽

pp. S55

Author(s):

Ruth A. Kowallis ◽

John M. Jakicic ◽

Amy Otto ◽

Fred Goss ◽

Elizabeth Nagle ◽

...

Keyword(s):

Energy Expenditure ◽

Resting Energy Expenditure ◽

Term Effect ◽

Short Term ◽

Short Term Effect ◽

Resting Energy

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Resting Energy Expenditure in Anorexia Nervosa: Measured versus Estimated

Journal of Nutrition and Metabolism ◽

10.1155/2012/652932 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 13

Author(s):

Marwan El Ghoch ◽

Marta Alberti ◽

Carlo Capelli ◽

Simona Calugi ◽

Riccardo Dalle Grave

Keyword(s):

Anorexia Nervosa ◽

Energy Expenditure ◽

Resting Energy Expenditure ◽

Short Term ◽

Severe Group ◽

Douglas Bag ◽

Douglas Bag Method ◽

Underweight Patients ◽

Assess Body Composition ◽

Resting Energy

Introduction. Aim of this study was to compare the resting energy expenditure (REE) measured by the Douglas bag method with the REE estimated with the FitMate method, the Harris-Benedict equation, and the Müller et al. equation for individuals with BMI < 18.5 kg/m2in a severe group of underweight patients with anorexia nervosa (AN).Methods. 15 subjects with AN participated in the study. The Douglas bag method and the FitMate method were used to measure REE and the dual energy X-ray absorptiometry to assess body composition after one day of refeeding.Results. FitMate method and the Müller et al. equation gave an accurate REE estimation, while the Harris-Benedict equation overestimated the REE when compared with the Douglas bag method.Conclusion. The data support the use of the FitMate method and the Müller et al. equation, but not the Harris-Benedict equation, to estimate REE in AN patients after short-term refeeding.

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