scholarly journals Analytic Strategies to Adjust Confounding using Exposure Propensity Scores and Disease Risk Scores: Nonsteroidal Antiinflammatory Drugs and Short-term Mortality in the Elderly

2005 ◽  
Vol 161 (9) ◽  
pp. 891-898 ◽  
Author(s):  
Til Stürmer ◽  
Sebastian Schneeweiss ◽  
M. Alan Brookhart ◽  
Kenneth J. Rothman ◽  
Jerry Avorn ◽  
...  
Keyword(s):  
Propensity Scores ◽  
Disease Risk ◽  
The Elderly ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Risk Scores ◽  
Short Term ◽  
Antiinflammatory Drugs ◽  
Short Term Mortality

scholarly journals Cardiac surgery in the elderly: What goals of care?

2017 ◽  
Vol 87 (2) ◽  
Author(s):  
Alessandra Pratesi ◽  
Francesco Orso ◽  
Camilla Ghiara ◽  
Aldo Lo Forte ◽  
Anna Chiara Baroncini ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
The Elderly ◽  
Risk Scores ◽  
Frailty Phenotype ◽  
Mortality And Morbidity ◽  
Geriatric Cardiology ◽  
Patient Reported ◽  
Short Term Mortality ◽  
Surgery In The Elderly

<p>At present, the majority of cardiac surgery interventions have been performed in the elderly with successful short-term mortality and morbidity, however significant difficulties must to be underlined about our capacity to predict long-term outcomes such as disability, worsening quality of life and loss of functional capacity.<br />The reason probably resides on inability to capture preoperative frailty phenotype with current cardiac surgery risk scores and consequently we are unable to outline the postoperative trajectory of an important patients’ centered outcome such as disability free survival. In this perspective, more than one geriatric statements have stressed the systematic underuse of patient reported outcomes in cardiovascular trials even after taking account of their relevance to older feel and wishes. Thus, in the next future is mandatory for geriatric cardiology community closes this gap of evidences through planning of trials in which patients’ centered outcomes are considered as primary goals of therapies as well as cardiovascular ones.</p>

Ambulatory Care: Medication Use Characteristics in an Ambulatory Elderly Population in Taiwan

1997 ◽  
Vol 31 (3) ◽  
pp. 308-314 ◽  
Author(s):  
Rou-Yee Chen Hsu ◽  
Min-Shung Lin ◽  
Mei-Huei Chou ◽  
Ming-Fang Lin
Keyword(s):  
Hormone Replacement ◽  
The Elderly ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Prescribing Patterns ◽  
Cross Sectional Survey ◽  
Antiinflammatory Drugs ◽  
Cross Sectional ◽  
Therapeutic Category ◽  
Prescribing Trends ◽  
Drug Expenditures

Objective To compare prescribing patterns between the elderly and nonelderly in 1994, to disclose prescribing trends in the elderly between 1992 and 1994, to explore whether drug utilization is in agreement with disease prevalence, and to identify suboptimal prescribing by drug category for ambulatory elderly patients. Design Cross-sectional survey at two separate time intervals. Setting All public group practice centers (GPCs) in Taiwan. Patients Ambulatory adults who visited GPCs during 1 random week. Those 65 years or over were classified as the elderly group, and those 20-64 years were the nonelderly group. Main Outcome Measures Mean diagnosis, drug use, and expenditure; frequency of diagnosis; and prescribing by therapeutic category. Results Data on 30 777 elderly and 38 184 nonelderly patients were collected in 1994. There was widespread use of antacids. Compared with nonelderly adults, the elderly were diagnosed with more diseases (1.3 vs. 1.2, respectively; p < 0.01), received more medications (4.7 vs. 4.1, respectively; p < 0.01), and had higher drug expenditures (5.4 vs. 4.6, respectively; p < 0.01). Chronic illness was more prevalent in the elderly, which accounted for the extensive use of cardiovascular drugs (32.1%), nonsteroidal antiinflammatory drugs (25.9%), and anxiolytics (15.9%). The upward trend in the elderly from 1992 to 1994 with hypertension (18.6% vs. 20.0%) or diabetes (9.2% vs. 10.9%) did not result in more cases of cerebrovascular disease (7.1% vs. 4.9%). There was a substantial increase in use of antispasmodic and gastroprokinetic agents (4.5% to 10.7%); the use of antacids decreased (73.6% to 63.4%) in the elderly. Conclusions Compared with the prevalence of disease, there was extensive nonspecific use of anxiolytics and antacids. However, lessened use of antidepressants and postmenopausal hormone replacement may have an impact on morbidity and mortality and deserves particular attention.

Oxaprozin-Induced Fulminant Hepatitis

1994 ◽  
Vol 28 (10) ◽  
pp. 1159-1161 ◽  
Author(s):  
Preston P. Purdum ◽  
Stacey L. Shelden ◽  
John W. Boyd ◽  
Mitchell L. Shiffman
Keyword(s):  
Fulminant Hepatic Failure ◽  
Hepatic Failure ◽  
Fulminant Hepatitis ◽  
The Elderly ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Antiinflammatory Drugs ◽  
Drug Induced ◽  
Hepatic Transaminase ◽  
Long Acting ◽  
Work Up

OBJECTIVE: To report oxaprozin-induced fulminant hepatic failure. CASE SUMMARY: A 56-year-old woman was admitted with fulminant hepatic failure. Work-up for potential etiologies was negative except for the use of oxaprozin for the preceding two months. Results of premortem liver biopsy were consistent with drug-induced hepatic injury similar to that previously reported with diclofenac. DISCUSSION: Although the literature describes elevation in hepatic transaminase concentrations associated with oxaprozin, fulminant hepatic failure has not been described previously. CONCLUSIONS: Elevations in hepatic transaminase concentrations and now fulminant hepatic failure have been shown to occur with oxaprozin, as previously seen with other nonsteroidal antiinflammatory drugs (NSAIDs). Transaminitis is a known adverse effect of NSAID use, but is usually mild and reversible with discontinuation of drug. Transaminitis may be more likely to occur in the elderly, in patients receiving concurrent potentially hepatotoxic medications, and possibly with the newer long-acting NSAIDs. The existence of fulminant hepatitis, although rare, supports the need for monitoring liver function enzymes during NSAID therapy.

scholarly journals Frailty is Independently Associated with Short Term Mortality and Hospitalization Due Heart Failure in the Elderly

2013 ◽  
Vol 62 (18) ◽  
pp. C50
Author(s):  
Ali Deniz ◽  
Çağlar Özmen ◽  
İlayda Gül Berk ◽  
Ertuğrul Bayram ◽  
Vildan Yüksekdağ ◽  
...  
Keyword(s):  
Heart Failure ◽  
The Elderly ◽  
Short Term ◽  
Short Term Mortality

scholarly journals Nonsteroidal Antiinflammatory Drugs Modify the Effect of Short-Term Air Pollution on Lung Function

2020 ◽  
Vol 201 (3) ◽  
pp. 374-378 ◽  
Author(s):  
Xu Gao ◽  
Brent Coull ◽  
Xihong Lin ◽  
Pantel Vokonas ◽  
Joel Schwartz ◽  
...  
Keyword(s):  
Air Pollution ◽  
Lung Function ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Short Term ◽  
Antiinflammatory Drugs

scholarly journals The effects of the 1996–2012 summer heat events on human mortality in Slovakia

2015 ◽  
Vol 23 (3) ◽  
pp. 58-70 ◽  
Author(s):  
Dalibor Výberči ◽  
Marek Švec ◽  
Pavol Faško ◽  
Henrieta Savinová ◽  
Milan Trizna ◽  
...  
Keyword(s):  
Knowledge Base ◽  
The Elderly ◽  
Negative Response ◽  
Short Term ◽  
Slovak Population ◽  
Specific Effects ◽  
Summer Heat ◽  
Short Term Mortality ◽  
Heat Events ◽  
Excess Deaths

AbstractThe impacts of summer heat events on the mortality of the Slovak population, both in total and for selected population sub-groups, are the foci of this study. This research is the first of its kind, focusing on a given population, and therefore one priority was to create a knowledge base for the issue and to basically evaluate existing conditions for the heat-mortality relationship in Slovakia. This article also aims to fill a void in current research on these issues in Europe. In addition to overall effects, we focused individually on the major historical heat events which occurred in the summers of 2007, 2010 and 2012. During the heat events, a non-negligible negative response in mortality was recorded and fatal effects were more pronounced during particularly strong heat events and periods which lasted for two or more days. In general, females and the elderly were the most sensitive groups in the population and mortality was characterized by several specific effects in individual population groups. The most extreme heat periods were commonly followed by a deficit in mortality, corresponding to a short-term mortality displacement, the pattern of which varied in specific cases. In general, displaced mortality appeared to compensate for a large part of heat-induced excess deaths.

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