RE: “ASSOCIATIONS BETWEEN BREAST CANCER RISK AND THE CATALASE GENOTYPE, FRUIT AND VEGETABLE CONSUMPTION, AND SUPPLEMENT USE”

To systematically investigate the epidemiology of breast cancer risk factors in Iran, we performed a systematic search via PubMed, Scopus, Web of Science and Persian databases for identifying studies published on breast cancer risk factors up to March 2019. Meta-analyses were done for risk factors reported in more than one study. We calculated odds ratios (ORs) with corresponding 95% confidence intervals (CIs) using a fixed/random-effects models.Thirty-nine studies entered into the meta-analysis. Pooling of ORs showed a significant harmful effect for risk factors including family history (OR: 1.80, 95%CI 1.47-2.12), HRT (OR: 5.48, 95%CI 0.84-1.74), ER positive (OR: 1.87, 95%CI 1.41-2.33), PR positive (OR: 1.84, 95%CI 1.38-2.29), stress condition (OR: 2.67, 95%CI 1.84-3.50), passive smokers (OR: 1.68, 95%CI 1.34-2.03), full-term pregnancy at age 30 (OR: 3.41, 95%CI 1.19-5.63), abortion (OR: 1.84, 95%CI 1.35-2.33), sweets consumption (OR: 1.71, 95%CI 1.32-2.11) and genotype Arg/Arg (crude OR: 1.59, 95%CI 1.07-2.10), whereas a significant protective effect for late menarche (OR: 0.58, 95%CI 0.32-0.83), nulliparity (OR: 0.68, 95%CI 0.39-0.96), 13 to 24 months of breastfeeding (OR: 0.68, 95%CI 0.46-0.90), daily exercise (OR: 0.59, 95%CI 0.44-0.73) and vegetable consumption (crude OR: 0.28, 95%CI 0.10-0.46).This study suggest that factors such as family history, HRT, ER and PR positive status, stress condition, passive smokers, late full-term pregnancy, abortion, sweets consumption and genotype Arg/Arg might increase risk of breast cancer development, whereas late menarche, nulliparity, 13-24 months breastfeeding, daily exercise and vegetable consumption had an inverse association with breast cancer development.

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Epidemiology Behind Fruit and Vegetable Consumption and Cancer Risk with Focus on Flavonoids

Plant Phenolics and Human Health ◽

10.1002/9780470531792.ch20 ◽

2009 ◽

pp. 471-487 ◽

Cited By ~ 1

Author(s):

Marta Rossi ◽

Eva Negri ◽

Cristina Bosetti ◽

Claudio Pelucchi ◽

Carlo La Vecchia

Keyword(s):

Cancer Risk ◽

Vegetable Consumption ◽

Fruit And Vegetable Consumption ◽

Fruit And Vegetable

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Fruit and vegetable consumption,Helicobacter pyloriantibodies, and gastric cancer risk: A pooled analysis of prospective studies in China, Japan, and Korea

International Journal of Cancer ◽

10.1002/ijc.30477 ◽

2016 ◽

Vol 140 (3) ◽

pp. 591-599 ◽

Cited By ~ 20

Author(s):

Tianyi Wang ◽

Hui Cai ◽

Shizuka Sasazuki ◽

Shoichiro Tsugane ◽

Wei Zheng ◽

...

Keyword(s):

Gastric Cancer ◽

Cancer Risk ◽

Prospective Studies ◽

Vegetable Consumption ◽

Pooled Analysis ◽

Fruit And Vegetable Consumption ◽

Gastric Cancer Risk ◽

Fruit And Vegetable

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Abstract P028: Fruit and Vegetable Consumption and the Risk of Heart Failure in Women

Circulation ◽

10.1161/circ.129.suppl_1.p028 ◽

2014 ◽

Vol 129 (suppl_1) ◽

Author(s):

Susanne Rautiainen ◽

Emily B Levitan ◽

Murray A Mittleman ◽

Alicja Wolk

Keyword(s):

Heart Failure ◽

Fruits And Vegetables ◽

Elderly Women ◽

Vegetable Consumption ◽

Smoking Status ◽

Fruit And Vegetable Consumption ◽

Fruit And Vegetable ◽

Total Consumption ◽

Supplement Use ◽

Incident Cases

Background: Although numerous studies have investigated fruit and vegetable consumption in association with cardiovascular disease, a limited number of studies have investigated the association with heart failure specifically. The aim of this study was to assess the association between fruit and vegetable consumption and the incidence of heart failure among middle-aged and elderly women. Methods: In September 1997, 33,669 women (aged 49-83 y) from the Swedish Mammography Cohort free of cancer, CVD and diabetes at baseline completed a food-frequency questionnaire. Women were followed for incident heart failure (hospitalization or mortality of heart failure as the primary cause) through December 2011 using administrative health registries. Cox proportional hazard models were used to calculate relative risks (RR) and 95% confidence intervals (CI). In multivariable models we adjusted for age at baseline, educational level, smoking status, body mass index, physical activity, hypertension, diabetes, family history of myocardial infarction, alcohol consumption, total energy intake, and dietary supplement use. Results: During 13.1 years of follow-up (442,324 person-years), we identified 1407 incident cases of heart failure. Total fruit and vegetable consumption was inversely associated with the risk of heart failure (the multivariable-adjusted RR in the highest quintile compared to the lowest was 0.81 (95% CI: 0.68-0.97, p for trend=0.03). When investigating fruit and vegetables separately we observed a statistically significant lower risk for vegetables (RR: 0.82; 95% CI: 0.69-0.98, p for trend=0.10) but not for fruits (RR: 0.94; 95% CI: 0.79-1.12, p for trend=0.24). Conclusions: In this population-based prospective cohort study of women, higher total consumption of fruits and vegetables was inversely associated with the risk of heart failure.

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