Elevated High-Sensitivity C-Reactive Protein as a Risk Marker of the Attenuated Relationship Between Serum Cholesterol and Cardiovascular Events at Older Age

Prognostic Value of High-Sensitivity C-Reactive Protein and Lipoprotein (a) in Acute Myocardial Infarction Patients Receiving Emergency Percutaneous Coronary InterventionIn order to study the prognostic value of high-sensitivity C-reactive protein (hsCRP) and lipoprotein (a) [Lp(a)] in patients receiving emergency percutaneous coronary intervention (PCI) following acute myocardial infarction (AMI), we retrospectively reviewed 118 patients who received emergency PCI following AMI from January 2007 to April 2010. The plasma levels of hsCRP and Lp(a) were determined. The incidence of cardiovascular events was compared between patients with an elevated hsCRP level and those with a normal hsCRP level and between patients with an elevated Lp(a) level and those with a normal Lp(a) level. Results showed that the incidence of cardiovascular events was 52.9% in the hsCRP-elevated group and 18.2% in the hsCRP-normal group displaying a significant difference (P=0.011). However, the incidence of cardiovascular events was 35.3% in the Lp(a)-elevated group and 46.4% in the Lp(a)-normal group and statistical analysis revealed no significant difference (P=0.733). HsCRP, but not Lp(a), can serve as a prognostic factor for patients receiving emergency PCI following AMI.

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N-terminal brain natriuretic peptide predicted cardiovascular events stronger than high-sensitivity C-reactive protein in hypertension: a LIFE substudy

Journal of Hypertension ◽

10.1097/01.hjh.0000239288.10013.04 ◽

2006 ◽

Vol 24 (8) ◽

pp. 1531-1539 ◽

Cited By ~ 23

Author(s):

Michael H Olsen ◽

Kristian Wachtell ◽

Olav W Nielsen ◽

Christian Hall ◽

Ragnhild Wergeland ◽

...

Keyword(s):

Brain Natriuretic Peptide ◽

Natriuretic Peptide ◽

Cardiovascular Events ◽

High Sensitivity ◽

C Reactive Protein ◽

Reactive Protein

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Additive Value of Immunoassay-Measured Fibrinogen and High-Sensitivity C-Reactive Protein Levels for Predicting Incident Cardiovascular Events

Circulation ◽

10.1161/circulationaha.106.634089 ◽

2006 ◽

Vol 114 (5) ◽

pp. 381-387 ◽

Cited By ~ 52

Author(s):

Samia Mora ◽

Nader Rifai ◽

Julie E. Buring ◽

Paul M Ridker

Keyword(s):

Cardiovascular Events ◽

High Sensitivity ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein

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Clinical use of high sensitivity C-reactive protein for the prediction of adverse cardiovascular events

Current Opinion in Cardiology ◽

10.1097/00001573-200311000-00008 ◽

2003 ◽

Vol 18 (6) ◽

pp. 471-478 ◽

Cited By ~ 63

Author(s):

José L. Torres ◽

Paul M. Ridker

Keyword(s):

Cardiovascular Events ◽

High Sensitivity ◽

Clinical Use ◽

C Reactive Protein ◽

Reactive Protein

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Letter by Vos et al Regarding Article, “Statins for the Primary Prevention of Cardiovascular Events in Women With Elevated High-Sensitivity C-Reactive Protein or Dyslipidemia: Results From the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) and Meta-Analysis of Women From Primary Prevention Trials”

Circulation ◽

10.1161/circulationaha.110.954016 ◽

2010 ◽

Vol 122 (23) ◽

Cited By ~ 3

Author(s):

Eddie Vos ◽

Colin P. Rose ◽

Pierre Biron

Keyword(s):

Primary Prevention ◽

Cardiovascular Events ◽

Meta Analysis ◽

High Sensitivity ◽

Intervention Trial ◽

C Reactive Protein ◽

Reactive Protein ◽

Prevention Trials

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Study of Correlation between High Sensitivity C-Reactive Protein and Serum Uric Acid in Acute Stroke

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2021/229 ◽

2021 ◽

Vol 10 (15) ◽

pp. 1074-1078

Author(s):

Jayachandra Jayachandra ◽

Arjun P. Chandrashekar ◽

Sowrabha S. Bhat ◽

Yoganand Yoganand ◽

Chethan Chethan ◽

...

Keyword(s):

Uric Acid ◽

Risk Factor ◽

Acute Stroke ◽

Serum Uric Acid ◽

High Sensitivity ◽

Risk Marker ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp ◽

Clinical Records

BACKGROUND Relationship between serum uric acid and cardiovascular system has been recognised since years. High-sensitivity C-reactive protein (hs-CRP) is a known risk factor for cardiovascular and cerebrovascular events. The role of uric acid as a risk factor for vascular disease and acute stroke is controversial and there is little information about it.1 It is unclear as to whether high uric acid concentrations promote or protect against the development of cerebrovascular disease, or simply acts as a passive marker of increased risk. As serum hs-CRP is an established risk factor for stroke, its positive correlation with serum uric acid levels would suggest that high serum uric acid could predict stroke risk. Also, it would prove to be a more cost-effective investigative tool in our present set up. METHODS In this cross-sectional study, we assessed 100 patients admitted with acute stroke in Victoria and Bowring and Lady Curzon Hospital from October 2016 to November 2018. Clinical records, routine investigations, radiological imaging, serum uric acid and hs-CRP of the patients were investigated. RESULTS Majority of the patients (33 %) belonged to the age group of > 70 yrs., followed by 61 - 70 yrs. (26 %). 69 % of the patients were males and 31 % were females. 67 % of them were hypertensive and 32 % were diabetic. 91 % had an hs-CRP level of > 3.0 mg / L and 8 % had hs-CRP levels between 1.0 and 3.0 mg / L. None of the female patients had a serum uric acid value > 6.5 mg / dL and none of the male patients had a uric acid level of > 7.0 mg / dL. There was a correlation between serum uric acid levels and serum hs-CRP levels in patients ≤ 50 yrs. of age. There was no correlation between serum hs-CRP levels and serum uric acid levels in patients more than 50 yrs. of age. CONCLUSIONS Our study showed that stroke is most common in persons > 70 yrs. of age and is more common in males compared to females. Hypertension is an independent risk factor for stroke. hs-CRP is a well-established risk marker for stroke, being raised in majority of stroke patients. Serum uric acid is not raised in all patients of acute stroke. So, it cannot be used as a risk marker for stroke. KEY WORDS hs-CRP, Serum Uric Acid, Acute Stroke

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The High-Sensitivity C-Reactive Protein to Prealbumin Ratio Predicts Adverse Cardiovascular Events after ST-Elevation Myocardial Infarction

The Heart Surgery Forum ◽

10.1532/hsf.3307 ◽

2021 ◽

Vol 24 (1) ◽

pp. E153-E157

Author(s):

Hongqiang Ren ◽

Li Zhao ◽

Yijun Liu ◽

Zhen Tan ◽

Guiquan Luo ◽

...

Keyword(s):

Myocardial Infarction ◽

Roc Curve ◽

Cardiovascular Events ◽

Cox Regression ◽

High Sensitivity ◽

St Elevation Myocardial Infarction ◽

C Reactive Protein ◽

Reactive Protein ◽

Increased Risk ◽

St Elevation

Background: This study evaluated the association of the high-sensitivity C-reactive protein to prealbumin ratio (CPR) with adverse cardiovascular events after ST-elevation myocardial infarction (STEMI) in patients undergoing primary percutaneous coronary intervention (PCI). Methods: The study included 682 patients who presented with STEMI and were treated with primary PCI. Patients were divided into 2 groups: high CPR (CPR ≥0.02) and low CPR (CPR <0.02). The primary endpoint of the study was the occurrence of major adverse cardiovascular events (MACE), defined as cardiovascular mortality or admission due to recurrent AMI or heart failure. Multivariate Cox regression models were used to assess the prognostic value of CPR on MACE in patients with STEMI. Results: During a median follow-up of 18 months, the accumulated incidence rate of MACE was significantly higher in the high-CPR group than in the low-CPR group (38.7% versus 12.0%, P < .01). Multivariate analysis revealed that CPR was an independent predictor for increased risk of MACE (hazard ratio = 3.27, 95% confidence interval [CI] 2.14 to 4.49, P < .01). Receiver operating characteristic (ROC) curve analysis showed that the area under the ROC curve for predicting the diagnosis of MACE was higher for CPR (0.82, 95% CI 0.77 to 0.87) than hs-CRP (0.70, 95% CI 0.65 to 0.75). Conclusion: CPR was independently associated with MACE and can be used for risk stratification in patients with STEMI.

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On-admission Serum High-Sensitivity C-Reactive Protein Level Independently Predicts In-Hospital Mortality and Adverse Cardiovascular Events in ST-elevation Acute Myocardial Infarction

Indian Journal of Clinical Cardiology ◽

10.1177/26324636211055370 ◽

2021 ◽

pp. 263246362110553

Author(s):

Anggoro Budi Hartopo ◽

Indah Sukmasari ◽

Maria Patricia Inggriani ◽

Thomas Rikl ◽

Stefi Geovani Valentin Hayon ◽

...

Keyword(s):

Myocardial Infarction ◽

Cardiovascular Events ◽

Multivariable Analysis ◽

High Sensitivity ◽

Inflammatory Biomarkers ◽

C Reactive Protein ◽

Reactive Protein ◽

St Elevation ◽

Hs Crp ◽

Elevation Acute Myocardial Infarction

Background: Inflammatory biomarkers are associated with adverse cardiovascular events during ST-elevation acute myocardial infarction (STEMI). We aimed to investigate the role of inflammatory biomarkers, high-sensitivity C-reactive protein (hs-CRP), and soluble ST-2 (sST2), for prediction of adverse cardiovascular events in STEMI. Methods: This was a prospective cohort study that consecutively enrolled patients with STEMI. Subjects were observed during hospitalization until discharge or fatal events happened. Adverse cardiovascular event was a compilation of cardiac mortality, acute heart failure, cardiogenic shock, reinfarction, and malignant ventricular arrhythmia. Blood samples were withdrawn on admission and inflammatory biomarkers (hs-CRP and sST2) were measured. The receiver operator characteristics curve and multivariable analysis were performed to determine which inflammatory biomarkers predict in-hospital adverse cardiovascular events and mortality. Result: Of 166 subjects, the in-hospital adverse cardiovascular events occurred in 41 subjects (24.6%) and mortality occurred in 16 subjects (9.6%). Subjects with in-hospital adverse cardiovascular events and mortality had a significantly higher hs-CRP level, but comparable sST2 level than subjects without events. The hs-CRP level was the most precise biomarkers to predict in-hospital adverse cardiovascular events (hs-CRP cut-off ≥2.75 mg/L) and mortality (hs-CRP cut-off ≥7 mg/L). Multivariable analysis indicated hs-CRP ≥2.75 mg/L as an independent predictor for in-hospital adverse cardiovascular events (adjusted odds ratio [OR]: 2.79, 95% confidence interval [CI]: 1.05-7.39, P = .039) and hs-CRP ≥7 mg/L for mortality (adjusted OR: 5.45, 95% CI: 1.13-26.18, P = .034) in STEMI. Conclusion: On admission, hs-CRP level independently predicted in-hospital adverse cardiovascular events, at cut-off level ≥2.75 mg/L, and mortality, at cut-off level ≥7 mg/L, in STEMI patients.

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