Vitamin B12 and hepatic enzyme serum levels correlate in male alcohol-dependent patients

Background: In this study, the aim was to evaluate the prevalence of vitamin D, vitamin B12, ferritin, and folate deficiencies in adolescence to clarify the need for early diagnosis and therapy. Methods: The medical records of adolescents between 10 and 18 years of age between 01 September 2018 and 28 February 2019 as healthy with non-specific complaints, or due to well-child care visits, were analyzed retrospectively. Results: A total of 1847/2507 (73.6%) adolescents were included in the study. The prevalence of vitamin D deficiency was 25.7% (n: 178/691). Vitamin B12 deficiency prevalence was 69.2% (n: 753/1088). The prevalence of anemia and ferritin deficiency was 4.8% and 13.26%. The prevalence of folate deficiency was 37.9% (n: 413/1088). VDD prevalence was statistically significantly higher in females than males (F/M:116/62). VB12D prevalence, the number and mean age of females with hemoglobin deficiency, and low ferritin levels was found to be statistically significantly higher in females than males. Conclusions: The prevalence of vitamin D, vitamin B12, folate deficiency and low ferritin levels was found to be high among adolescents. In particular, adolescents admitting with non-specific complaints and for control purposes in big cities must be considered to be at risk for the deficiency of these vitamins and low level of ferritin.

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Evaluation of the Relationship Between Serum levels of Zinc, Vitamin B12, Vitamin D and Clinical outcomes in Patients with COVID‐19

Journal of Medical Virology ◽

10.1002/jmv.27277 ◽

2021 ◽

Author(s):

Habibesadat Shakeri ◽

Amir Azimian ◽

Hamed Ghasemzadeh‐Moghaddam ◽

Mohammadreza Safdari ◽

Mehdi Haresabadi ◽

...

Keyword(s):

Vitamin D ◽

Vitamin B12 ◽

Clinical Outcomes ◽

Serum Levels ◽

The Relationship

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Increased vitamin D binding protein levels are associated with irritable bowel syndrome

Turkish Journal of Biochemistry ◽

10.1515/tjb-2020-0305 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Elif Börekci ◽

Mahmut Kılıç ◽

Zeynep Ozan ◽

Hasan Börekci ◽

Tekin Yıldırım ◽

...

Keyword(s):

Vitamin D ◽

Logistic Regression ◽

Irritable Bowel Syndrome ◽

Regression Analysis ◽

Vitamin B12 ◽

Logistic Regression Analysis ◽

Binding Protein ◽

Serum Levels ◽

Vitamin D Binding Protein ◽

Irritable Bowel

Abstract Objectives There is no reliable and valid biomarker to identify Irritable bowel syndrome (IBS) and its subtypes. The aim of this study is to explore potential serum biomarkers that may be associated with IBS subtypes, particularly in the vitamin D pathway. Methods The study population comprised 75 IBS patients and 79 controls. Patients divided into IBS subtypes. Routine biochemical parameters, 25-OH-vitamin D, vitamin D binding protein (VDBP) and vitamin D receptor (VDR) serum levels were compared between IBS subtypes and controls. Factors related to IBS subtypes were examined by multivariate logistic regression analysis. Results Vitamin D levels were lower; VDBP and VDR were higher in all IBS patients than in controls (p<0.001; 0.047 and 0.029, respectively). According to logistic regression analysis, VDBP was a disease-related parameter as much as vitamin D in all IBS subtypes. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were higher especially in diarrhea-dominant IBS (IBS-D) (p=0.041; 0.046) and vitamin B12 were significantly lower in constipation-dominant IBS (IBS-C) (p=0.001). Conclusions Increased VDBP levels were associated with all IBS subtypes. Patients, especially in IBS-D, had higher serum levels of VDBP, CRP and ESR. Vitamin B12 deficiency, which we consider as a result of the disease, was more common in IBS-C.

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