scholarly journals Metachronous gastric MALT lymphoma and early gastric cancer: is residual lymphoma a risk factor for the development of gastric carcinoma?

2005 ◽  
Vol 16 (8) ◽  
pp. 1232-1236 ◽  
Author(s):  
C. Copie-Bergman ◽  
C. Locher ◽  
M. Levy ◽  
M.T. Chaumette ◽  
C. Haioun ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Early Gastric Cancer ◽  
Gastric Carcinoma ◽  
Malt Lymphoma ◽  
Gastric Malt Lymphoma ◽  
Residual Lymphoma

scholarly journals Metachronous gastric MALT lymphoma and early gastric cancer

2006 ◽  
Vol 17 (4) ◽  
pp. 724 ◽  
Author(s):  
M. Raderer ◽  
B. Streubel ◽  
S. Wöhrer ◽  
A. Chott
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Malt Lymphoma ◽  
Gastric Malt Lymphoma

scholarly journals A Case Report of Early Gastric Cancer with Gastric Malt Lymphoma

2017 ◽  
Vol 42 (1) ◽  
pp. 47-53
Author(s):  
Kanechika Den ◽  
Chikara Kunisaki ◽  
Jun Kimura ◽  
Hirochika Makino ◽  
Itaru Endo
Keyword(s):  
Gastric Cancer ◽  
Case Report ◽  
Early Gastric Cancer ◽  
Malt Lymphoma ◽  
Gastric Malt Lymphoma

scholarly journals Clinicopathological significance of primitive phenotypes in early gastric cancer with differentiated histology

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Zhi-Yi Zhou ◽  
Jie Sun ◽  
Qing Guo ◽  
Hai-Bin Zhao ◽  
Zhi-Hua Zhou
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Early Gastric Cancer ◽  
Endoscopic Resection ◽  
Independent Risk Factor ◽  
Lymphatic Invasion ◽  
Clinicopathological Features ◽  
Surgical Operation ◽  
Tissue Sections ◽  
Clinicopathological Significance

Abstract Background Certain gastric cancers exhibit some primitive phenotypes, which may indicate a high malignancy. In histologically differentiated early gastric cancer (EGC), the presence and the clinicopathological significance of the primitive phenotype remain unclear. Methods Using immunohistochemical staining we detected the expression of three primitive phenotypic markers SALL4, Glypican-3(GPC3), and AFP in whole tissue sections of differentiated EGC (gastrectomy specimens, n = 302). For those cases with primitive phenotypes, we analyzed their clinicopathological features and evaluated whether the criteria for endoscopic resection were met. Results We found that 9.3% (28/302) of all differentiated EGC cases have primitive phenotypes, and most of these cases (25/28) exhibit a histomorphology similar to conventional differentiated EGC. Patients with primitive phenotypes had a deeper invasion, a higher rate of ulcer and lymphatic invasion than cases without primitive phenotype. Moreover, patients with primitive phenotypes displayed a significantly higher frequency of LNM than those without (57.1% vs 8.8%, P < 0.001). Multivariate analysis revealed that presence of primitive phenotypes was an independent risk factor for LNM (P = 0.001, HR 6.977, 95% CI: 2.199–22.138). Interestingly, we found 2 cases with primitive phenotypes developed LNM, and they both met the expanded indications of endoscopic resection for differentiated EGC. Conclusions A small number of differentiated EGC have primitive phenotypes, which were closely related to LNM and were an independent risk factor for LNM. Given its highly aggressive behavior, differentiated EGC with primitive phenotypes should be evaluated with stricter criteria before endoscopic resection, or considered to give an additional surgical operation after endoscopic resection.

scholarly journals Expression of stromal cell-derived factor-1α is an independent risk factor for lymph node metastasis in early gastric cancer

2011 ◽  
Vol 2 (6) ◽  
pp. 1197-1202 ◽  
Author(s):  
IK-CHAN SONG ◽  
ZHE-LONG LIANG ◽  
JUNG-CHAN LEE ◽  
SONG-MEI HUANG ◽  
HA-YON KIM ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Stromal Cell ◽  
Independent Risk Factor ◽  
Node Metastasis ◽  
Stromal Cell Derived Factor

Mo1188 Histologically Mixed-Type Early Gastric Cancer Is a Risk Factor for Metastasis and Recurrence

2017 ◽  
Vol 85 (5) ◽  
pp. AB455-AB456
Author(s):  
Ken Ohnita ◽  
Takuji Gotoda ◽  
Tsuneo Oyama ◽  
Noboru Kawata ◽  
Akiko Takahashi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Early Gastric Cancer ◽  
Mixed Type

Early gastric cancer: The importance of early diagnosis on prognosis of gastric carcinoma.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 29-29 ◽  
Author(s):  
T. Bouca-Machado ◽  
H. Santos Sousa ◽  
E. Lima-da-costa ◽  
J. Pinto-de-Sousa ◽  
J. Preto ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Early Gastric Cancer ◽  
Gastric Carcinoma ◽  
Early Diagnosis ◽  
Cox Regression ◽  
Gastroesophageal Junction ◽  
Venous Invasion ◽  
Cox Regression Analysis ◽  
Advanced Tumors

29 Background: The aim of this study was to evaluate the characteristics of early gastric cancer (EGC) in comparison to advanced tumors and its role in patient's prognosis. Methods: This study was related to 1,272 patients admitted with gastric or gastroesophageal junction carcinoma in our department, between January 1988 and December 2008. During this period the incidence of EGC was 12.68% (3.62% T0, 42.75% T1a and 53.62% T1b). Several clinical, pathological and staging parameters were evaluated according to classification in EGC and advanced tumors. Results: Significant differences were observed in location (p<0.001); type of resection surgery (p<0.001) and of lymphadenectomy (p=0.008 for Siewert and p<0.001 for Japanese classifications) with less radical surgery in EGC patients. This type of tumors presented characteristics associated with a better prognosis in the following pathological parameters: tumor dimensions (p<0.001), macroscopic form (p<0.001), Ming's classification (p<0.001), venous invasion (p<0.001) and lymphatic permeation (p<0.001). The 5-year survival rate of this series was 33.7%. There were significant differences in survival curves according to classification in EGC and advanced tumors (73% at 5 years and 26% at 5 years, respectively). Cox-regression analysis identified age, T and lymph node ratio as independent prognostic factors. There was no significant differences in age (cut-off 45 years), but there was significant differences in lymph node metastasis (p<0.001). In 23.87% of EGC there was lymph node involvement, with significant differences (p=0.002) according to the depth wall invasion [T0 (100% N0), T1a (91.5% N0, 8.5% N1), T1b (60.8% N0, 21.6% N1, 13.5% N2, 4.1% N3a)]. Conclusions: The EGC percentage in our series was lower in comparison with other countries with high incidence of gastric cancer. The prognosis of the patients with gastric carcinoma continues to be gloomy mainly due to the late diagnosis and, given that the surgical treatment doesn't seem plausible of achieving a margin of significant additional progression, the need for an early diagnosis emerges if an improvement in patient survival is desired. No significant financial relationships to disclose.

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