scholarly journals Registration-based automated lesion detection and therapy evaluation of tumors in whole body PET-MR images

2017 ◽  
Vol 28 ◽  
pp. v20
Author(s):  
H. Ahlström ◽  
S. Ekström ◽  
T. Sjöholm ◽  
R. Strand ◽  
J. Kullberg ◽  
...  
Keyword(s):  
Lesion Detection ◽  
Whole Body ◽  
Mr Images ◽  
Therapy Evaluation

scholarly journals Diagnostic Value of Whole-Body MRI Short Protocols in Bone Lesion Detection in Multiple Myeloma Patients

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1053
Author(s):  
Davide Ippolito ◽  
Teresa Giandola ◽  
Cesare Maino ◽  
Davide Gandola ◽  
Maria Ragusi ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow Involvement ◽  
Bone Lesion ◽  
Diagnostic Value ◽  
Lesion Detection ◽  
Lower Limbs ◽  
Whole Body ◽  
Bone Lesions ◽  
Whole Body Mri ◽  
Mri Protocol

The aim of the study is to evaluate the effectiveness of short whole-body magnetic resonance imaging (WBMRI) protocols for the overall assessment of bone marrow involvement in patients with multiple myeloma (MM), in comparison with standard whole-body MRI protocol. Patients with biopsy-proven MM, who underwent a WBMRI with full-body coverage (from vertex to feet) were retrospectively enrolled. WBMRI images were independently evaluated by two expert radiologists, in terms of infiltration patterns (normal, focal, diffuse, and combined), according to location (the whole skeleton was divided into six anatomic districts: skull, spine, sternum and ribs, upper limbs, pelvis and proximal two-thirds of the femur, remaining parts of lower limbs) and lytic lesions number (<5, 5–20, and >20). The majority of patients showed focal and combined infiltration patterns with bone lesions predominantly distributed in the spine and pelvis. As skull and lower limbs are less frequently involved by focal bone lesions, excluding them from the standard MRI protocol allows to obtain a shorter protocol, maintaining a good diagnostic value.

scholarly journals Improved PET/MRI attenuation correction in the pelvic region using a statistical decomposition method on T2-weighted images

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Elin Wallstén ◽  
Jan Axelsson ◽  
Joakim Jonsson ◽  
Camilla Thellenberg Karlsson ◽  
Tufve Nyholm ◽  
...  
Keyword(s):  
Attenuation Correction ◽  
Research Study ◽  
Standardized Uptake Value ◽  
Ground Truth ◽  
Whole Body ◽  
Mr Images ◽  
Pelvic Region ◽  
Mri Scans ◽  
The Mean ◽  
Prostate Cancer Research

Abstract Background Attenuation correction of PET/MRI is a remaining problem for whole-body PET/MRI. The statistical decomposition algorithm (SDA) is a probabilistic atlas-based method that calculates synthetic CTs from T2-weighted MRI scans. In this study, we evaluated the application of SDA for attenuation correction of PET images in the pelvic region. Materials and method Twelve patients were retrospectively selected from an ongoing prostate cancer research study. The patients had same-day scans of [11C]acetate PET/MRI and CT. The CT images were non-rigidly registered to the PET/MRI geometry, and PET images were reconstructed with attenuation correction employing CT, SDA-generated CT, and the built-in Dixon sequence-based method of the scanner. The PET images reconstructed using CT-based attenuation correction were used as ground truth. Results The mean whole-image PET uptake error was reduced from − 5.4% for Dixon-PET to − 0.9% for SDA-PET. The prostate standardized uptake value (SUV) quantification error was significantly reduced from − 5.6% for Dixon-PET to − 2.3% for SDA-PET. Conclusion Attenuation correction with SDA improves quantification of PET/MR images in the pelvic region compared to the Dixon-based method.

scholarly journals Tumor Burden in Patients with Neurofibromatosis Types 1 and 2 and Schwannomatosis: Determination on Whole-Body MR Images

Radiology ◽  
2009 ◽  
Vol 250 (3) ◽  
pp. 665-673 ◽  
Author(s):  
Wenli Cai ◽  
Ara Kassarjian ◽  
Miriam A. Bredella ◽  
Gordon J. Harris ◽  
Hiroyuki Yoshida ◽  
...  
Keyword(s):  
Tumor Burden ◽  
Whole Body ◽  
Mr Images

scholarly journals High Grade tumor vs stroke. Utility of PET and MRI corregistration

ANALES RANM ◽  
2021 ◽  
Vol 138 (138(02)) ◽  
pp. 176-179
Author(s):  
M.N. Cabrera-Martín ◽  
P. Romero Fernández ◽  
M.K. Meneses Navas ◽  
P. Pérez-Segura ◽  
M. Yus Fuertes ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
High Grade Glioma ◽  
Whole Body ◽  
High Grade ◽  
Mr Images ◽  
Fdg Uptake ◽  
Area Of Interest ◽  
Pet Ct ◽  
Adjacent Brain

Sometimes, the clinical presentation of a brain tumour mimics that of stroke or viceversa. In these cases it is useful to evaluate follow-up with MR. The coregistration of PET and MR images improves the diagnostic performance of both techniques. In the area of interest, FDG uptake of any degree, with reference to the adjacent brain tissue uptake, should be considered suggestive of tumor if it corresponds to brain injury in MR, even when the FDG uptake is equal to or lower than that of the normal cerebral cortex. We present a case in which coregistration of images from both techniques contributed to the differential diagnosis of stroke and high-grade glioma, whole-body PET/CT ruled out metastatic etiology, and the results led to surgery.

Low-dose whole-body CT using deep learning image reconstruction: image quality and lesion detection

2021 ◽  
Vol 94 (1121) ◽  
pp. 20201329
Author(s):  
Yoshifumi Noda ◽  
Tetsuro Kaga ◽  
Nobuyuki Kawai ◽  
Toshiharu Miyoshi ◽  
Hiroshi Kawada ◽  
...  
Keyword(s):  
Deep Learning ◽  
Image Reconstruction ◽  
Image Quality ◽  
Low Dose ◽  
Standard Dose ◽  
Lesion Detection ◽  
Whole Body ◽  
Hybrid Iterative Reconstruction ◽  
Whole Body Ct ◽  
Attenuation Values

Objectives: To evaluate image quality and lesion detection capabilities of low-dose (LD) portal venous phase whole-body computed tomography (CT) using deep learning image reconstruction (DLIR). Methods: The study cohort of 59 consecutive patients (mean age, 67.2 years) who underwent whole-body LD CT and a prior standard-dose (SD) CT reconstructed with hybrid iterative reconstruction (SD-IR) within one year for surveillance of malignancy were assessed. The LD CT images were reconstructed with hybrid iterative reconstruction of 40% (LD-IR) and DLIR (LD-DLIR). The radiologists independently evaluated image quality (5-point scale) and lesion detection. Attenuation values in Hounsfield units (HU) of the liver, pancreas, spleen, abdominal aorta, and portal vein; the background noise and signal-to-noise ratio (SNR) of the liver, pancreas, and spleen were calculated. Qualitative and quantitative parameters were compared between the SD-IR, LD-IR, and LD-DLIR images. The CT dose-index volumes (CTDIvol) and dose-length product (DLP) were compared between SD and LD scans. Results: The image quality and lesion detection rate of the LD-DLIR was comparable to the SD-IR. The image quality was significantly better in SD-IR than in LD-IR (p < 0.017). The attenuation values of all anatomical structures were comparable between the SD-IR and LD-DLIR (p = 0.28–0.96). However, background noise was significantly lower in the LD-DLIR (p < 0.001) and resulted in improved SNRs (p < 0.001) compared to the SD-IR and LD-IR images. The mean CTDIvol and DLP were significantly lower in the LD (2.9 mGy and 216.2 mGy•cm) than in the SD (13.5 mGy and 1011.6 mGy•cm) (p < 0.0001). Conclusion: LD CT images reconstructed with DLIR enable radiation dose reduction of >75% while maintaining image quality and lesion detection rate and superior SNR in comparison to SD-IR. Advances in knowledge: Deep learning image reconstruction algorithm enables around 80% reduction in radiation dose while maintaining the image quality and lesion detection compared to standard-dose whole-body CT.

The clinical potential of ultra-high-speed echo-planar imaging

1990 ◽  
Vol 333 (1632) ◽  
pp. 507-514 ◽  
Keyword(s):  
Real Time ◽  
High Speed ◽  
Echo Planar Imaging ◽  
Lesion Detection ◽  
Whole Body ◽  
Planar Imaging ◽  
Cardiac Events ◽  
Ultra High Speed ◽  
Movement Artefact ◽  
Echo Planar

Ultra-high-speed echo-planar imaging (EP1) allows acquisition of a complete twodimensional image in 64 to 128 ms devoid of movement artefact and without sacrifice of contrast due to relaxation time effects. In conventional whole-body MRI, however, obtrusive movement artefact and extended imaging time, resulting from the need to apply multiple sequences to facilitate lesion detection and pathological characterization, remain limitations. Reduced total examination time increases patient tolerance and throughput • furthermore optimization of contrast to achieve maximal conspicuity of particular features in liver or brain pathology is achieved simply and interactively by real time adjustment of the imaging parameters. The method provides the opportunity to study in real time dynamic events such as flow phenomena in the vascular and cerebrospinal fluid compartments of the brain as well as the kinetics of administered contrast agents, EPI is the only means of capturing the irregular motion of aperiodic cardiac events and bowel peristalsis.

Improvement of the acquisition of a large amount of MR images on a conventional whole body system

1999 ◽  
Vol 17 (3) ◽  
pp. 471-474 ◽  
Author(s):  
Uwe Klose ◽  
Michael Erb ◽  
Dirk Wildgruber ◽  
Edgar Müller ◽  
Wolfgang Grodd
Keyword(s):  
Whole Body ◽  
Body System ◽  
Mr Images

scholarly journals Sphere extraction in MR images with application to whole-body MRI

2009 ◽  
Author(s):  
Christian Wachinger ◽  
Simon Baumann ◽  
Jochen Zeltner ◽  
Ben Glocker ◽  
Nassir Navab
Keyword(s):  
Whole Body ◽  
Mr Images ◽  
Whole Body Mri

Detection of metastases in breast cancer: Is whole body PET/MR better than PET/CT?

2014 ◽  
Vol 32 (26_suppl) ◽  
pp. 15-15
Author(s):  
Eleonora Teplinsky ◽  
Akshat Pujara ◽  
Francisco J. Esteva ◽  
Linda Moy ◽  
Amy Melsaether ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Treatment Response ◽  
Metastatic Lesion ◽  
Lesion Detection ◽  
Whole Body ◽  
Reference Standard ◽  
Therapeutic Implications ◽  
Metastatic Setting ◽  
Pet Ct ◽  
Pathology Reports

15 Background: Whole body PET/CT is commonly utilized in breast cancer (BC) patients (pts). Limitations include assessment of treatment response in bone metastases (mets), high physiologic uptake in brain and liver, and cumulative radiation exposure. The site of mets can have prognostic and therapeutic implications. PET/MR, an exciting new hybrid technology, delivers less radiation than PET/CT. Our aim was to compare the differences in metastatic lesion detection using PET/CT & PET/MR in all BC subtypes. Methods: After a single 18-FDG injection, pts had whole body PET/CT for staging and assessment of treatment response. They were transported to another NYU facility & then underwent whole body PET/MR. PET/MR & PET/CT images were each read by a radiologist blinded to prior exams or reports. Number of mets (up to 6) per organ was recorded. 2 experienced radiologists unblinded to imaging and pathology reports served as the “reference standard”. Results: Forty-eight BC pts underwent PET/CT & PET/MR (28 in metastatic setting, 5 for staging & 15 to rule out recurrence). Median age: 55; range 32-79 with 31 ER+/HER2-, 8 ER+/HER2+, 2 ER-/HER2+, 6 ER-/HER2+, 1 unknown. 20 pts had no distant mets on scan. In the remaining 28 pts, the reference standard detected 9 liver, 18 bone, 7 lung/pleura, 5 brain & 10 lymph node (LN) metastases; some patients had ≥1 metastatic site. PET/CT had more false positives (FP) and false negatives (FN) in the detection of mets (Table). PET/MR had 1 FP in the liver. PET/MR accurately detected 2 bone (ER+/HER2-), 3 liver (ER+/HER2-), 2 LN (1 ER+/HER2+; 1 ER+/HER2-) and 5 brain lesions (1 ER+/HER2-; 3 ER-/HER2+; 1 ER+/HER2+) in 10 unique pts that were not identified on PET/CT. 1 liver (ER+/HER2-) and 2 brain mets (ER-/HER2+) identified on PET/MR were previously unknown. Conclusions: Our preliminary data suggest that PET/MR outperformed PET/CT in detecting mets in the liver, brain, LN & possibly bone. Prospective studies of PET/MR are warranted to determine whether early detection of mets, including occult brain mets in HER2+ pts, impacts survival.[Table: see text]

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