Dynamic Characteristics Analysis of a Rigid Body System with Spatial Multi-Point Supports

This paper presents the dynamic characteristics analysis of a rigid body system with spatial multi-point elastic supports, as well as the sensitivity analysis of support parameters. A rigid object is characterized by six degrees-of-freedom (DOFs) motions and considering the spatial location vector decomposition of elastic supports, a rigid body system dynamic model with spatial multi-point elastic supports is derived via the Lagrangian energy method. The system modal frequencies are calculated, and to be verified by finite element modal analysis results. Next, based on the above-mentioned model, system modal frequencies are obtained under different support locations, where the support stiffness components are different. Interpolate the stiffness components corresponding to each support location, calculate system modal frequencies, and the response surface model (RSM) for system modal frequencies is established. Further, based on the RSM modal analysis results, the allowable support location for the system modal insensitive area can be obtained. At last, a lubricating oil-tank system with four supports is taken as an example, and the effects of support spatial locations and stiffness components on the system inherent characteristics are discussed. This present work can provide a basis for the dynamic design of the spatial location and stiffness for this type of installation structures.

Multimorbidity in Hospitalized Patients Admitted to General Practice Departments and Its Implications for the General Practice Healthcare System: A Four-Year Longitudinal Study in China

Objective: China and many developing countries has placed high expectations on the general practice healthcare system in terms of lowering medical costs and improving the health status of the multimorbid population in recent years. However, the prevalence of multimorbidity among inpatients attending the general practice department of hospitals and its policy implications are largely unknown. The current study aimed to analyze the prevalence of comorbidities among inpatients attending the general practice department of the tertiary Grade-A Hospitals in China, and put forward evidence-based policy recommendations.Methods: Between December 2016 and November 2020, 351 registered general practitioners from 27 tertiary hospitals were selected, and their direct admissions were evaluated. The rate and composition ratio were used for descriptive analysis of the clinical and epidemiological characteristics of multimorbidity. A backward stepwise algorithm was used to explore independent variables. The absence of multicollinearity and plausible interactions among variables were tested to ensure the robustness of the logistic regression model. The pyramid diagram was used to show the link between gender and the involved human body system in multimorbidity.Results: Multimorbidity was present in 93.1% of the 64, 395 patients who were admitted directly. Multimorbidity was significantly more prevalent in patients aged 45–59 years (OR=3.018, 95% CI=1.945–4.683), 60–74 years (OR = 4.349, 95% CI = 2.574–7.349), ≥75 years (OR = 7.804, 95% CI = 3.665–16.616), and those with body mass index (BMI) ≥ 28 kg/m2 (OR = 3.770, 95% CI = 1.453–9.785). The circulatory system was found to be the most commonly involved human body system in multimorbidity, accounting for 79.2% (95% CI = 78.8–79.5%) of all cases. Significant gender inequity was further observed in the involved human body system in multimorbidity.Conclusion: Multimorbidity is likely common among the inpatients attending the general practice department of hospitals in China and many developing countries, with significant gender inequity in the involved human body systems. Effective countermeasures include establishing a GP-PCIC multimorbidity prevention and control model and enhancing the multimorbidity of elderly and obese patients at both the clinical and healthy lifestyle levels. The diagnosis and treatment capabilities of GPs on the circulatory, endocrine, metabolic, digestive, and respiratory systems should be prioritized.

Pattern of Malignant Tumors in Najran, Saudi Arabia: A 5-year Retrospective Study

Background: The relative frequency of malignant tumors has been reported to have an association with age, gender, and location. The current study is a retrospective study to assess the pattern and relative frequency of different malignant tumors in Najran, Saudi Arabia. Methods and Results: All patients from both genders were included in the study from June 2014 to May 2019, and data were retrieved from the records of confirmed cancer cases at the departments of pathology. For 5 years, a total of 763 cases [325(42.6%) men and 438(57.4%) women] and 37 types of malignant tumors were diagnosed in Najran. According to the histopathological diagnosis, carcinomas were the most frequent tumors (n=564, 73.9%). According to the affected organ/body system, tumors of the gastrointestinal system were the commonest malignancy, observed in 156 (20.4%) of the patients (91 men and 65 women). Finally, the chi-square test revealed that the frequency of malignant tumors climbed as age increased (P=0.0005). Conclusion: The relative frequency of several cancers in Najran showed that the most common cancers in both genders are in the following order: gastrointestinal, thyroid, breast, skin and soft tissue cancers, and lymphoma. In addition, women are more affected than men, and increasing age is a risk factor to develop a malignancy.

Evaluation and Quantification of Anionic Surfactant in the Gomti River at Lucknow City, India

In this paper, an attempt has been made to check the level of surfactants particularly in drinking water, which can lead to toxicity in human body system. In this study, a total of 10 locations were selected to enumerate the concentration of surfactants and other physicochemical parameters with metals in the flowing water of river during pre-monsoon 2019. Analyzed result showed that the concentration of surfactants was significantly high and other parameters were also high. It was also found that river at the vicinity of town areas or midstream in the Lucknow city contained high amount of an anionic surfactants due to the nonpoint sources generated by human activities, low concentration was found in upstream, and average concentration was found in downstream, showing natural degradation of surfactants. The values of other parameters were higher than the prescribed limit, which is the serious problem for human being.

PAF Physiology in Target Organ Systems—A Deep Dive to Understand the PAF Mystery in Pathogenesis of Disease

The purpose of this literature review is to gain an overview of the role of platelet-activating factor (PAF) within each of the body systems and how it contributes to normal and pathophysiological states. The review showed that there are multiple functions of PAF that are common to several body systems; however, there is little evidence to explain why PAF has this affect across multiple systems. Interestingly, there seems to be conflicting research as to whether PAF is an overall protective or pathogenic pathway. Within this research, it was found that there are different pathways depending on the specific body system, as well as between body systems. However, one universal function reported in the literature is of PAF as a pro-inflammatory molecule. Overall, this review identified five major functions of PAF: vasoconstriction, increased inflammation, vascular remodeling, increased edema, and endothelial permeability.