Prognostic factors analysis of 343 patients with adenocarcinoma of esophagogastric junction

Abstract BACKGROUND The incidence rate of adenocarcinoma of esophagogastric junction (AEG) was significantly increased over the past two decades. Surgery remians the only way to cure. Indeed, there are currently few studies on Chinese AEG patients. The purpose of this study was to retrospectively analyze the survival and prognostic factors of AEG patients in our center. METHODS Between January 2008 and September 2014, 249 AEG patients who underwent radical resection were enrolled in this retrospective study, including 196 males and 53 females, with a median age of 64 (range 31–82). Prognostic factors were assessed with Log-rank test, Cox univariate and multivariate analysis. RESULTS The 5-year survival rate of all patients was 49%. The median survival time of all enrolled patients was 70.1 months. Pathology type, intraoperative blood transfusion, tumor size, adjuvant chemotherapy, hospital stay days, serum CA199, CA125, CA242 and CEA, pTNM stage, lymphovascular or perineuronal invasion, and the ratio of positive to negative lymph nodes (PNLNR) were significant associated with overall survival when analyzed with univariate analysis. CONCLUSIONS Our study found that intraoperative blood transfusion, tumor size, adjuvant chemotherapy, serum CEA and PNLNR, postoperative hospital stays were independent risk factors.

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Radiation Therapy without Surgery for Spinal Metastases: Clinical Outcome and Prognostic Factors Analysis for Pain Control

Global Spine Journal ◽

10.1055/s-0032-1326948 ◽

2012 ◽

Vol 2 (3) ◽

pp. 137-141

Author(s):

Akira Matsumura ◽

Manabu Hoshi ◽

Masatsugu Takami ◽

Takahiko Tashiro ◽

Hiroaki Nakamura

Keyword(s):

Radiation Therapy ◽

Prognostic Factors ◽

Clinical Outcome ◽

Pain Control ◽

Spinal Metastases ◽

Factors Analysis

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Multicentric French study on adult intracranial ependymomas: prognostic factors analysis and therapeutic considerations from a cohort of 152 patients

Brain ◽

10.1093/brain/awm046 ◽

2007 ◽

Vol 130 (5) ◽

pp. 1338-1349 ◽

Cited By ~ 82

Author(s):

P. Metellus ◽

M. Barrie ◽

D. Figarella-Branger ◽

O. Chinot ◽

R. Giorgi ◽

...

Keyword(s):

Prognostic Factors ◽

Factors Analysis ◽

French Study ◽

Therapeutic Considerations

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A 22 years survival and prognostic factors analysis in a homogeneous series of 64 patients with advanced cancer of the tongue and the floor of the mouth

Journal of Cranio-Maxillofacial Surgery ◽

10.1016/j.jcms.2015.01.007 ◽

2015 ◽

Vol 43 (3) ◽

pp. 376-381 ◽

Cited By ~ 4

Author(s):

Jose L. López-Cedrún ◽

Jesús Andrés de Llano

Keyword(s):

Prognostic Factors ◽

Advanced Cancer ◽

Floor Of The Mouth ◽

Factors Analysis

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A prospective appraisal of preoperative body mass index in D2-resected patients with non-metastatic gastric carcinoma and Siewert type II/III adenocarcinoma of esophagogastric junction: results from a large-scale cohort

Oncotarget ◽

10.18632/oncotarget.19251 ◽

2017 ◽

Vol 8 (40) ◽

pp. 68165-68179 ◽

Cited By ~ 4

Author(s):

Lei Huang ◽

Zhi-Jian Wei ◽

Tuan-Jie Li ◽

Yu-Ming Jiang ◽

A-Man Xu

Keyword(s):

Body Mass Index ◽

Gastric Carcinoma ◽

Body Mass ◽

Esophagogastric Junction ◽

Large Scale ◽

Type Ii ◽

Siewert Type ◽

Siewert Type Ii ◽

Preoperative Body Mass Index ◽

Adenocarcinoma Of Esophagogastric Junction

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Prognostic Impact of Pathological Adverse Features in Surgically Resected Adenocarcinoma of Esophagogastric Junction

10.21203/rs.3.rs-626858/v1 ◽

2021 ◽

Author(s):

Qianchao Liao ◽

Jiabin Zheng ◽

Wenjun Xiong ◽

Junjiang Wang ◽

Xu Hu ◽

...

Keyword(s):

Risk Factor ◽

Esophagogastric Junction ◽

Independent Risk Factor ◽

Univariate Analysis ◽

Stage Ii ◽

Prognostic Impact ◽

Provincial Hospital ◽

Adenocarcinoma Of Esophagogastric Junction ◽

The Status ◽

Poor Differentiation

Abstract Objective The prognostic value of lymphovascular invasion (LVI), perineural invasion (PNI), and poor differentiation (PD) has been widely studied in different solid tumors. However, it was still controversial in adenocarcinoma of esophagogastric junction (AEG). We investigated the prognostic impact of combining LVI, PNI and PD for predicting the survival in patients with AEG.Methods We retrospectively investigated the data of patients who performed surgical resection of AEG on Guangdong Provincial Hospital and Guangdong Provincial Hospital of Chinese Medicine from Jan. 2004 to Dec. 2018. According to the status of LVI, PNI and differentiation, pathological adverse features were divided into three groups: 0, 1 or 2 and 3 adverse features, their impact on prognosis was evaluated. Results Univariate analysis indicated pT, pN, LVI , PNI , PD and pathological adverse features were risk factors for both overall survival (OS) and disease-specific survival (DSS), and multivariate analysis indicated that pathological adverse feature was independent risk factor for both OS and DSS. In subgroup analyses, adverse features were independent risk factor for DSS of stage II AEG but not for stage I or III.Conclusions The pathological adverse features were independent prognostic factors for AEG patients and they can help for further risk stratification in stage II patients.

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Long-term outcomes and prognostic factor analysis of resected Siewert type II adenocarcinoma of esophagogastric junction in China: a seven-year study

BMC Surgery ◽

10.1186/s12893-020-00926-1 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Yiding Feng ◽

Youhua Jiang ◽

Qiang Zhao ◽

Jinshi Liu ◽

Hangyu Zhang ◽

...

Keyword(s):

Prognostic Factors ◽

Adjuvant Chemotherapy ◽

Blood Transfusion ◽

Hospital Stay ◽

Tumor Size ◽

Esophagogastric Junction ◽

Perineural Invasion ◽

Univariate Analysis ◽

Rank Test ◽

Duration Of Hospital Stay

Abstract Background The incidence rate of adenocarcinoma of the esophagogastric junction (AEG) has significantly increased over the past two decades. Surgery remains the only curative treatment. However, there are currently few studies on Chinese AEG patients. The purpose of this study was to retrospectively analyze the survival and prognostic factors of AEG patients in our center. Methods Between January 2008 and September 2014, 249 AEG patients who underwent radical resection were enrolled in this retrospective study, including 196 males and 53 females, with a median age of 64 (range 31–82). Prognostic factors were assessed with the log-rank test and Cox univariate and multivariate analyses. Results The 5-year survival rate of all patients was 49%. The median survival time of all enrolled patients was 70.1 months. Pathological type, intraoperative blood transfusion, tumor size, adjuvant chemotherapy, duration of hospital stay, serum CA199, CA125, CA242 and CEA, pTNM stage, lymphovascular or perineural invasion, and the ratio of positive to negative lymph nodes (PNLNR) were significantly associated with overall survival when analyzed in univariate analysis. Conclusions Our study found that adjuvant chemotherapy, PNLNR, intraoperative blood transfusion, tumor size, perineural invasion, serum CEA, and duration of hospital stay after surgery had significance in multivariate analysis and were independent risk factors for survival.

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