scholarly journals EasyModel: user-friendly tool for building and analysis of simple mathematical models in systems biology

2019 ◽  
Author(s):  
Jordi Bartolome ◽  
Rui Alves ◽  
Francesc Solsona ◽  
Ivan Teixido

Abstract Summary EasyModel is a new user-friendly web application that contains ready-for-simulation versions of the BioModels Database, and allows for the intuitive creation of new models. Its main target audience is the experimental biologist and students of bioinformatics or systems biology without programming skills. Expert users can also benefit from it by implementing basic models quickly and downloading the code for further tailoring. Availability and implementation Freely available on the web at https://easymodel.udl.cat. Implementation is described in its own section.

2018 ◽  
pp. 82-101
Author(s):  
Bruce Rogers

This chapter aims to build better models of web traffic. It shows how web traffic is roughly power law distributed, in which a highly concentrated “head” of the Web is coupled with a long, diffuse “tail” of tiny sites. These power law-like patterns have provoked vigorous debate about whether the Web is dominated by new or old elites. To address these issues, this chapter builds new models that scale seamlessly from the largest websites down to hundreds of smaller ones. It builds and tests these models with a rich dataset from Hitwise, a web measurement firm. As this chapter shows, digital audience growth follows predictable patterns. These patterns look much like the growth of cities over time, or the fluctuations of stocks on an equity market (more on that shortly), or even the growth and decline of biological species. This chapter borrows mathematical models and techniques from other disciplines to demonstrate these patterns, focus with a focus on understanding the principles and intuition behind the models.


2019 ◽  
Vol 2 ◽  
pp. 1-4
Author(s):  
Petra Jílková ◽  
Jiri Cajthaml

<p><strong>Abstract.</strong> Within the currently solved project of Czech Historical Atlas, an extensive analytic research of existing historical atlases was conducted with the aim of creating a large database of Czech (Czechoslovak) and foreign historical atlases released after 1950. During the analysis, the team collected information about more than 400 items. Beside the standard bibliographic description (title, author, country of origin, language, availability in the library, etc.), the database contains additional detail information on the content of the atlases, such as a chronological or spatial determination of the maps or applied methods of thematic cartography, that cannot be found in any library catalogue. The database is published as a complementary web application to Czech Historical Atlas web portal. Besides the large amount of collected information, the database of historical atlases in the form of an interactive web application provides a user-friendly visual analytic platform that enables the user to analyse information about historical atlases easily and effectively across fully interactive dashboards. The database can be used not only by academics in the field of historical and atlas cartography but also by broad public interested in this topic. The web application exists in Czech and English version to meet both, Czech and international public.</p>


PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5650 ◽  
Author(s):  
Yannan Fan ◽  
Maria Habib ◽  
Jianguo Xia

Xeno-miRNAs are microRNAs originating from exogenous species detected in host biofluids. A growing number of studies have suggested that many of these xeno-miRNAs may be involved in cross-species interactions and manipulations. To date, hundreds of xeno-miRNAs have been reported in different hosts at various abundance levels. Based on computational predictions, many more miRNAs could be potentially transferred to human circulation system. There is a clear need for bioinformatics resources and tools dedicated to xeno-miRNA annotations and their potential functions. To address this need, we have systematically curated xeno-miRNAs from multiple sources, performed target predictions using well-established algorithms, and developed a user-friendly web-based tool—Xeno-miRNet—to allow researchers to search and explore xeno-miRNAs and their potential targets within different host species. Xeno-miRNet currently contains 1,702 (including both detected and predicted) xeno-miRNAs from 54 species and 98,053 potential gene targets in six hosts. The web application is freely available at http://xeno.mirnet.ca.


In India, most of the populace is subordinate to cultivating for survival. Numerous farmers are not mindful of the exterior world and the specialized progressions around cultivating. They confront a parcel of issues in their day-to-day life such as they need to keep track of their trim stock, their tractors, and devices. Most of the farmers do not have any thought almost the rates of the crops and their items and they offer their items at any fetched price. In today's world, farmers get news through daily papers and television. Farmers don’t get the data or news around the closest showcase that's displayed in their locale or indeed offer and track their crops. So, because of this they more often do not get any thought about the current news regarding the farming plans. In conclusion, they have to sell their products at a very low cost to a local supplier. We are looking forward to protecting these anticipating farmers from being cheated from their reasonable share of their income. These days versatile applications and web administrations are making things less difficult by satisfying our day by day needs for data, communication, amusement, or relaxation. Web applications have brought an unused insurgency. In this paper, we offer one such web application called “Genesis - Farmers Digital Assistant” which is as of now beneath advancement by us. This web benefit can offer assistance to farmers, customers, and suppliers have a less difficult, easy-to-use, and less time-consuming solution. Farmers Digital Assistant could be a web application that's built on keeping the farmers, providers, and customers in intellect. It keeps a farmer overhauled with all the data related to crops, pesticides, bug sprays, money related segment, etc. It gives nitty gritty data about which crop to cultivate in which season and which crop is appropriate for that specific region where the farmer is situated in. The government of India is investing a lot to form the utilization of the web accommodation for agribusiness purposes but the hindrance is the literacy of farmers with their access to the advanced world presently. So, with this web application, we make it a point to create our project user-friendly for the farmers in specific.


Author(s):  
JUNXIA GUO ◽  
HAO HAN

The technology that integrates various types of Web contents to build a new Web application through end-user programming is widely used nowadays. However, the Web contents do not have a uniform interface for accessing the data and computation. Most of the general Web users access information on the Web through applications until now. Hence, designing a uniform and flexible programmatic interface for integration of different Web contents is unavoidable. In this paper, we propose an approach that can be used to analyze Web applications automatically and reuse the information of Web applications through the programmatic interface we designed. Our approach can support the flexible integration of Web applications, Web services and Web feeds. In our experiments, we use a large number of Web pages from different types of Web applications and achieve the integration by the proposed programmatic interfaces. The experimental results show that our approach brings to the end-users a flexible and user-friendly programming environment.


2018 ◽  
Author(s):  
Yannan Fan ◽  
Maria Habib ◽  
Jianguo Xia

Xeno-miRNAs are microRNAs originating from exogenous species detected in host biofluids. A growing number of studies have suggested that many of these xeno-miRNAs may be involved in cross-species interactions by targeting host mRNAs. To date, hundreds of xeno-miRNAs have been reported in different hosts at various abundance levels. Many more miRNAs could be potentially transferred to human circulation system based on computational predictions. There is a clear need for bioinformatics resources and tools dedicated to xeno-miRNA annotations and their potential functions. To address this need, we have systematically curated xeno-miRNAs from multiple sources, performed target predictions using well-established algorithms, and developed a user-friendly web-based tool - Xeno-miRNet to allow researchers to search and explore xeno-miRNAs and their potential targets within different host species. Xeno-miRNet currently contains 1,702 (including both detected and predicted) xeno-miRNAs from 54 species and 98,053 potential gene targets in six hosts. The web application is freely available at http://xeno.mirnet.ca .


2017 ◽  
Vol 2 (3) ◽  
pp. 172-177 ◽  
Author(s):  
Karzan Wakil ◽  
Dayang N.A. Jawawi

Web engineering is a systematic approach to develop web applications, and numerous web engineering methods have been proposed. These methods were extended through defining new models by using different mechanisms to capture the web application concepts. Due to the complexity rising of web applications, the web engineering methods cannot provide web solutions anymore. Even though Interaction Flow Modeling Language (IFML) is recently proposed as a new method for developing web applications, it has limitations. Therefore these methods need to be improved. In this paper, we present the ability of IFML extensibility to support new concerns from web applications. Moreover, we extend IFML through UML mechanisms to support new concerns from the context to the user interface. The new IFML solves the lack of context web application through defining a new model and becomes a new direction to develop concerns modern web applications.


In India, most of the populace is subordinate to cultivating for survival. Numerous farmers are not mindful of the exterior world and the specialized progressions around cultivating. They confront a parcel of issues in their day-to-day life such as they need to keep track of their trim stock, their tractors, and devices. Most of the farmers do not have any thought almost the rates of the crops and their items and they offer their items at any fetched price. In today's world, farmers get news through daily papers and television. Farmers don’t get the data or news around the closest showcase that's displayed in their locale or indeed offer and track their crops. So, because of this they more often do not get any thought about the current news regarding the farming plans. In conclusion, they have to sell their products at a very low cost to a local supplier. We are looking forward to protecting these anticipating farmers from being cheated from their reasonable share of their income. These days versatile applications and web administrations are making things less difficult by satisfying our day by day needs for data, communication, amusement, or relaxation. Web applications have brought an unused insurgency. In this paper, we offer one such web application called “Genesis - Farmers Digital Assistant” which is as of now beneath advancement by us. This web benefit can offer assistance to farmers, customers, and suppliers have a less difficult, easy-to-use, and less time-consuming solution. Farmers Digital Assistant could be a web application that's built on keeping the farmers, providers, and customers in intellect. It keeps a farmer overhauled with all the data related to crops, pesticides, bug sprays, money related segment, etc. It gives nitty gritty data about which crop to cultivate in which season and which crop is appropriate for that specific region where the farmer is situated in. The government of India is investing a lot to form the utilization of the web accommodation for agribusiness purposes but the hindrance is the literacy of farmers with their access to the advanced world presently. So, with this web application, we make it a point to create our project user-friendly for the farmers in specific.


2018 ◽  
Author(s):  
Yannan Fan ◽  
Maria Habib ◽  
Jianguo Xia

Xeno-miRNAs are microRNAs originating from exogenous species detected in host biofluids. A growing number of studies have suggested that many of these xeno-miRNAs may be involved in cross-species interactions by targeting host mRNAs. To date, hundreds of xeno-miRNAs have been reported in different hosts at various abundance levels. Many more miRNAs could be potentially transferred to human circulation system based on computational predictions. There is a clear need for bioinformatics resources and tools dedicated to xeno-miRNA annotations and their potential functions. To address this need, we have systematically curated xeno-miRNAs from multiple sources, performed target predictions using well-established algorithms, and developed a user-friendly web-based tool - Xeno-miRNet to allow researchers to search and explore xeno-miRNAs and their potential targets within different host species. Xeno-miRNet currently contains 1,702 (including both detected and predicted) xeno-miRNAs from 54 species and 98,053 potential gene targets in six hosts. The web application is freely available at http://xeno.mirnet.ca .


2018 ◽  
Vol 48 (3) ◽  
pp. 84-90 ◽  
Author(s):  
E. A. Lapchenko ◽  
S. P. Isakova ◽  
T. N. Bobrova ◽  
L. A. Kolpakova

It is shown that the application of the Internet technologies is relevant in the selection of crop production technologies and the formation of a rational composition of the machine-and-tractor fl eet taking into account the conditions and production resources of a particular agricultural enterprise. The work gives a short description of the web applications, namely “ExactFarming”, “Agrivi” and “AgCommand” that provide a possibility to select technologies and technical means of soil treatment, and their functions. “ExactFarming” allows to collect and store information about temperature, precipitation and weather forecast in certain areas, keep records of information about crops and make technological maps using expert templates. “Agrivi” allows to store and provide access to weather information in the fi elds with certain crops. It has algorithms to detect and make warnings about risks related to diseases and pests, as well as provides economic calculations of crop profi tability and crop planning. “AgCommand” allows to track the position of machinery and equipment in the fi elds and provides data on the weather situation in order to plan the use of agricultural machinery in the fi elds. The web applications presented hereabove do not show relation between the technologies applied and agro-climatic features of the farm location zone. They do not take into account the phytosanitary conditions in the previous years, or the relief and contour of the fi elds while drawing up technological maps or selecting the machine-and-tractor fl eet. Siberian Physical-Technical Institute of Agrarian Problems of Siberian Federal Scientifi c Center of AgroBioTechnologies of the Russian Academy of Sciences developed a software complex PIKAT for supporting machine agrotechnologies for production of spring wheat grain at an agricultural enterprise, on the basis of which there is a plan to develop a web application that will consider all the main factors limiting the yield of cultivated crops.


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