scholarly journals ADVERSE EFFECTS OF EXTRADURAL AND INTRATHECAL OPIATES: REPORT OF A NATIONWIDE SURVEY IN SWEDEN

1982 ◽  
Vol 54 (5) ◽  
pp. 479-486 ◽  
Author(s):  
L.L. GUSTAFSSON ◽  
B. SCHILDT ◽  
K. JACOBSEN
Keyword(s):  
Adverse Effects ◽  
Nationwide Survey

scholarly journals Overview of lithium's use: a nationwide survey

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Xabier Pérez de Mendiola ◽  
Diego Hidalgo-Mazzei ◽  
Eduard Vieta ◽  
Ana González-Pinto
Keyword(s):  
Adverse Effects ◽  
Clinical Guidelines ◽  
Lithium Treatment ◽  
Scientific Evidence ◽  
Plasma Concentrations ◽  
Maintenance Phase ◽  
Nationwide Survey ◽  
Developed Countries ◽  
Lithium Salts ◽  
National Society

Abstract Background Lithium is considered the gold standard treatment for bipolar disorder (BD). Current clinical guidelines and scientific evidence support its use as a first-line treatment in BD. However, over the last two decades, there has been a downward tendency in lithium's use in several developed countries. Based on a nationwide survey, this study's objective is to analyze in a large sample of psychiatrists relevant issues of the use of lithium salts in BD. Methods Data were collected through an anonymous survey sent by email among 500 psychiatrists who belong to a National Society of Psychiatry (Spanish Society of Biological Psychiatry). The survey is a self-administered questionnaire consisting of 21 items on the most key aspects of lithium's use (indication, dosage, monitoring, and information for patients). Results 212 psychiatrists completed the survey. 70% of psychiatrists prescribe lithium to more than 50% of patients diagnosed with BD. Adverse effects are the main reason not to use lithium salts. Over 75% of the participants consider lithium salts the treatment of choice for the maintenance phase of BD, both in women and men. Most of the participants (> 50%) start lithium after the first affective episode, use conservative plasma concentrations (0.6–0.8 mmol/L), and generally prescribe it twice a day. 57% of psychiatrists who treat patients under 18 do not use lithium in this population. About 70% of the survey respondents use official protocols to inform and monitor patients on lithium treatment. Conclusions From the results of the present study, it can be concluded that the use of lithium in Spain is in line with the recommendations of the main international clinical guidelines and current scientific literature. The first reason not to prescribe lithium in our country is the perception of its adverse effects and not the aspects related to its practical use or its effectiveness. Considering that BD is a chronic disease with a typical onset in adolescence, the low rate of prescription of lithium salts in patients under 18 must be thoroughly studied.

scholarly journals Internists’ Perceptions of Proton Pump Inhibitor Adverse Effects and Impact on Prescribing Practices: Results of a Nationwide Survey

2018 ◽  
Vol 11 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Jacob E. Kurlander ◽  
Mark Kolbe ◽  
Joel H. Rubenstein ◽  
Caroline R. Richardson ◽  
Michele Heisler ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Adverse Effects ◽  
Proton Pump ◽  
Nationwide Survey ◽  
Prescribing Practices

scholarly journals The Yellow Knight Fights Back: Toxicological, Epidemiological, and Survey Studies Defend Edibility of Tricholoma equestre

Toxins ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 468 ◽  
Author(s):  
Piotr Klimaszyk ◽  
Piotr Rzymski
Keyword(s):  
Adverse Effects ◽  
Adverse Events ◽  
Healthy Subjects ◽  
Biochemical Parameters ◽  
Single Case ◽  
Nationwide Survey ◽  
Biochemical Alterations ◽  
Epidemiological Database ◽  
Study Support ◽  
Hematological And Biochemical Parameters

Rhabdomyolysis, a condition associated with the consumption of Yellow Knight mushrooms (Tricholoma equestre), was first reported in 2001. In response, some countries began to consider the mushroom as poisonous, whereas in others it is still consumed. In the present study, a nationwide survey of Polish mushroom foragers (n = 1545) was conducted to estimate the frequency of T. equestre consumption. The epidemiological database on mushroom poisonings in Poland was analyzed from the year 2008. Hematological and biochemical parameters were followed for a week in 10 volunteers consuming 300 g of molecularly identified T. equestre. More than half the foragers had consumed T. equestre at least once in their lifetime and a quarter had consumed it consecutively. The frequency of adverse events was low and no rhabdomyolysis was reported. The toxicological database indicated that mushrooms from the Tricholoma genus caused poisonings less frequently than mushrooms with well-established edibility and not a single case of rhabdomyolysis has been reported within the last decade. The volunteers consuming T. equestre revealed no hematological or biochemical alterations and no adverse effects were observed. The findings of this study support the view that T. equestre is edible if consumed in rational amounts by healthy subjects.

scholarly journals Nationwide Survey of Patients’ Perspectives Regarding Their Radiation and Multidisciplinary Cancer Treatment Experiences

2019 ◽  
Vol 15 (12) ◽  
pp. e1010-e1017 ◽  
Author(s):  
Narek Shaverdian ◽  
Debra N. Yeboa ◽  
Liz Gardner ◽  
Paul M. Harari ◽  
Kaiping Liao ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Odds Ratio ◽  
Nationwide Survey ◽  
Informed Decision Making ◽  
Web Based ◽  
Patients With Cancer ◽  
The Past ◽  
Physician Patient Communication ◽  
Physician Patient ◽  
Better Than

PURPOSE: The perspectives of patients with cancer about their treatment can inform interventions to improve the approaches of treating oncologists and experiences of future patients. We sought to identify areas where current toxicity management, informed consent processes, and physician-patient communication merit improvement. METHODS: In a Web-based survey administered from March to May 2018 using quota-based sampling to draw a nationwide sample of US patients with cancer treated with radiotherapy within the past 5 years, we evaluated patient perceptions of adequacy of information about adverse effects, severity of actual adverse effects experienced, and experiences divergent from expectations. RESULTS: Among 403 respondents, 18% felt inadequately informed about what adverse effects to expect from radiotherapy, and 37% experienced radiation adverse effects that they wished they had known more about. Similar proportions of patients treated with chemotherapy (36%) and surgery (34%) experienced toxicities related to those treatments that they wished they had known more about. Patients who noted their adverse effects to be minimal versus severe were significantly more likely to feel informed about radiotherapy adverse effects (odds ratio, 13.05; 95% CI, 5.6 to 30.38; P < .001). Across all evaluated measures, a majority of patients indicated that they did not experience the potentially anticipated radiotherapy adverse effect or that it was the same as or better than expected. CONCLUSION: This study suggests that experiences with radiation adverse effects generally are congruent with expectations. Nevertheless, improvement of pretreatment counseling across all cancer therapy modalities seems warranted to improve informed decision making and treatment experiences.

scholarly journals Are dietary supplements dangerous? Assessing how society perceives the usage of dietary supplements – results of the preliminary analysis of nationwide survey data

2018 ◽  
Vol 12 (2) ◽  
pp. 13-17
Author(s):  
Przemysław Kardas ◽  
Jakub Dorożyński ◽  
Paula Zdanowicz ◽  
Dawid Tyrna ◽  
Paulina Lis ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Dietary Supplements ◽  
Online Survey ◽  
Nationwide Survey ◽  
Normal Diet ◽  
Pharmacovigilance System ◽  
Negative Effects ◽  
Patterns Of Use ◽  
Other Substances ◽  
Mixed Feelings

Background: Dietary supplements (DSs) are concentrated sources of nutrients and/or other substances, whose purpose is to supplement the normal diet. Their consumption in Poland has been on the rise, leading to numerous concerns. However, current legislation does not provide any background for a relevant pharmacovigilance system. Therefore, little is known about their adverse effects (AEs) or patterns of use in Poland. To shed some light on this, we conducted a nationwide survey. Aim of the study: To assess the prevalence of, and the reasons for, the use of dietary supplements in Poland via national survey with a collection and an analyse of supposed adverse effects of dietary supplements. Material and methods: The study was conducted using an online survey based on the original questionnaire. In this report, we present the results of the analysis of the first 200 responses. Results: As many as 55.5% (111) of respondents were ‘definitely sure’ or ‘rather sure’ about DSs safety. However, 70.5% (141) believed that they could have negative effects. Over 3/4 (153) of respondents used DSs themselves, and 61.0% (122) used them within last 12 months. Of those using DSs, 11.1% (17) reported diverse AEs, with GI tract irritation and mental disturbances being the most common (experienced by 35.3% (6), and 17.6% (3) of those reporting AE s, respectively). Conclusions: Respondents had mixed feelings about DS safety. Despite that, they used these products frequently. Of a note is high incidence of adverse effects experienced by DS users. This undoubtedly points to the need for a relevant pharmacovigilance system.

scholarly journals Adverse effects of extradural and intrathecal opiates: report of a nationwide survey in Sweden

Pain ◽  
1982 ◽  
Vol 14 (2) ◽  
pp. 199
Author(s):  
L. L. Gustafsson ◽  
B. Schildt ◽  
K. Jacobsen
Keyword(s):  
Adverse Effects ◽  
Nationwide Survey

scholarly journals Overview of Lithium´s Use: A Nationwide Survey

2020 ◽  
Author(s):  
Xabier Pérez de Mendiola ◽  
Diego Hidalgo-Mazzei ◽  
Eduard Vieta ◽  
Ana González-Pinto
Keyword(s):  
Adverse Effects ◽  
Clinical Guidelines ◽  
Lithium Treatment ◽  
Scientific Evidence ◽  
Plasma Concentrations ◽  
Maintenance Phase ◽  
Nationwide Survey ◽  
Developed Countries ◽  
Lithium Salts ◽  
National Society

Abstract Background: Lithium is considered the gold standard treatment for bipolar disorder (BD). Its use as a first-line treatment in BD is supported by current clinical guidelines and scientific evidence. However, over the last two decades it has been observed a downward tendency in lithium´s use in several developed countries. Based on a nationwide survey, the objective of this study is to analyze in a large sample of psychiatrists relevant issues of the use of lithium salts in BD.Methods: Data were collected through an anonymous survey sent by email among 500 psychiatrists who belong to a National Society of Psychiatry (Spanish Society of Biological Psychiatry). The survey is a self-administered questionnaire consisting of 21 items on the most key aspects of the use of lithium (indication, dosage, monitoring and information for patients).Results: 212 psychiatrists completed the survey. 70% of psychiatrists prescribe lithium to more than 50% of patients diagnosed with BD. Adverse effects are the main reason not to use lithium salts. Over 75% of the participants consider lithium salts the treatment of choice for the maintenance phase of BD, both in women and men. Most of the participants (> 50%) start lithium after the first affective episode, use conservative plasma concentrations (0.6-0.8 mmol/L) and generally prescribe it twice a day. 57% of psychiatrists who treat patients under 18 do not use lithium in this population. About 70% of the survey respondents use official protocols to inform and monitor patients who are on lithium treatment.Conclusions: From the results of the present study it can be concluded that the use of lithium in Spain is in line with the recommendations of the main international clinical guidelines and current scientific literature. The first reason not to prescribe lithium in our country is the perception of its adverse effects and not the aspects related to its practical use or its effectiveness. Considering that BD is a chronic disease that has a typical onset in adolescence, the reasons for the low rate of prescription of lithium salts in patients under 18 must be thoroughly studied.

The Influence of Specimen Thickness in Quantitative Electron Energy Loss Spectroscopy

1980 ◽  
Vol 38 ◽  
pp. 112-113
Author(s):  
Nestor J. Zaluzec
Keyword(s):  
Quantitative Analysis ◽  
Adverse Effects ◽  
Energy Loss ◽  
Electron Energy ◽  
Electron Energy Loss Spectroscopy ◽  
Materials Science ◽  
Light Element ◽  
Specimen Thickness ◽  
Element Analysis ◽  
Electron Energy Loss

The application of electron energy loss spectroscopy (EELS) to light element analysis is rapidly becoming an important aspect of the microcharacterization of solids in materials science, however relatively stringent requirements exist on the specimen thickness under which one can obtain EELS data due to the adverse effects of multiple inelastic scattering.1,2 This study was initiated to determine the limitations on quantitative analysis of EELS data due to specimen thickness.

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