Development and validation of a new assay for O6-alkylguanine-DNA-alkyltransferase based on the use of an oligonucleotide substrate, and its application to the measurement of DNA repair activity in extracts of biopsy samples of human urinary bladder mucosa

1989 ◽  
Vol 10 (7) ◽  
pp. 1203-1208 ◽  
Author(s):  
Vassilis L. Souliotis ◽  
Aris Giannopoulos ◽  
Ioannis Koufakis ◽  
Stella Kaila ◽  
Costas Dimopoulos ◽  
...  
1987 ◽  
Vol 59 (1) ◽  
pp. 36-39 ◽  
Author(s):  
J. Y. JEREMY ◽  
V. TSANG ◽  
D. P. MIKHAILIDIS ◽  
H. ROGERS ◽  
R. J. MORGAN ◽  
...  

2008 ◽  
Vol 27 (5) ◽  
pp. 421-428 ◽  
Author(s):  
Nicola Arrighi ◽  
Serena Bodei ◽  
Angelo Peroni ◽  
Giuseppe Mirabella ◽  
Danilo Zani ◽  
...  

2020 ◽  
Vol 401 (12) ◽  
pp. 1487-1493
Author(s):  
Stephan Kiontke ◽  
Tanja Göbel ◽  
Annika Brych ◽  
Alfred Batschauer

AbstractDrosophila, Arabidopsis, Synechocystis, human (DASH)-type cryptochromes (cry-DASHs) form one subclade of the cryptochrome/photolyase family (CPF). CPF members are flavoproteins that act as DNA-repair enzymes (DNA-photolyases), or as ultraviolet(UV)-A/blue light photoreceptors (cryptochromes). In mammals, cryptochromes are essential components of the circadian clock feed-back loop. Cry-DASHs are present in almost all major taxa and were initially considered as photoreceptors. Later studies demonstrated DNA-repair activity that was, however, restricted to UV-lesions in single-stranded DNA. Very recent studies, particularly on microbial organisms, substantiated photoreceptor functions of cry-DASHs suggesting that they could be transitions between photolyases and cryptochromes.


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