Effects of Obesity and Low and High Isoflavones in Soy Protein Concentrate Diet on Liver Steatosis

Abstract Objectives To examine the role of isoflavones levels in soy protein diets on protection against Non-Alcoholic Fatty Liver Disease (NAFLD) in obese rat model (8 weeks of feeding). Methods 42 six-week old lean (n = 21) and obese (n = 21) Zucker rats were randomly assigned to one of 3 dietary groups: casein diet (C = control), soy protein with low isoflavones (LIF), or soy protein with high isoflavones (HIF) for 8 weeks (n = 7 rats/group). Rats were weighed twice weekly. After 8 weeks, all rats were sacrificed and livers taken for histopathological analysis. Results Obese rats gained significantly more weight (P < 0.0001) than lean rats for all three diet groups, with no significant difference between obese (O) LIF vs. OHIF groups (P = 0.19). Body weight was higher in OHIF (717 g) than in OLIF and OC (694 and 620, respectively). No significant difference between LC, LLIF and LHIF (P between 0.3 and 0.6) was found. Liver steatosis scores were significantly higher in obese rats compared to lean rats (P < 0.001). In addition, differences in the steatosis scores between OC vs. OHIF (P < 0.0001) were more significant than differences between OC vs. OLIF (P = 0.01), and OLIF vs. OHIF (P = 0.01) groups, showing the protective effect against liver steatosis exerted by soy protein concentrate with higher isoflavones. Conclusions We found that soy protein concentrate protects against liver steatosis and protection is more significant with higher concentration of isoflavones. Funding Sources USDA.

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Iron Requirement of Chicks Fed a Semipurified Diet Based on Casein and Soy Protein Concentrate

Poultry Science ◽

10.3382/ps.0740412 ◽

1995 ◽

Vol 74 (2) ◽

pp. 412-415 ◽

Cited By ~ 17

Author(s):

SEIJI AOYAGI ◽

DAVID H. BAKER

Keyword(s):

Soy Protein ◽

Soy Protein Concentrate ◽

Protein Concentrate ◽

Iron Requirement

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A Very Low CP Level Reduced Diarrhoea and Productivity in Weaner Pigs, but No Differences between Post-Weaning Diets Including Soybean Meal or Soy Protein Concentrate Were Found

Animals ◽

10.3390/ani11030678 ◽

2021 ◽

Vol 11 (3) ◽

pp. 678

Author(s):

Julie C. Lynegaard ◽

Niels J. Kjeldsen ◽

Julie K. Bache ◽

Nicolai R. Weber ◽

Christian F. Hansen ◽

...

Keyword(s):

Growth Performance ◽

Soy Protein ◽

Soybean Meal ◽

Nutrient Utilization ◽

Positive Control ◽

Negative Control ◽

Soy Protein Concentrate ◽

Protein Concentrate ◽

Feed Conversion ◽

And Performance

Soy protein concentrate improves nutrient utilization and growth performance compared to soybean meal, and diets with a low crude protein (CP) level decreases diarrhoea. The objectives were to (1) test a low CP diet based on different soy products, and (2) to test a very-low CP diet (15.1%) with amino acids (AA) on diarrhoea and productivity. A total of 5,635 weaned pigs (~28 days), were assigned to five dietary treatments; PC (positive control): Standard CP levels (192, 189, 191 g/kg CP) with 2500 ppm ZnO; NC (negative control): Same as PC without ZnO; SP (Soy protein concentrate): Low CP levels (176, 174, 191 g/kg CP); SB (Soybean meal): Low CP levels (177, 176, 191 g/kg CP); and XLA (X-low CP + AA): Very low CP levels (154, 151, 191 g/kg CP) with AA. The PC and XLA diets reduced diarrhoea by 41 and 61%, respectively, compared to the NC group, while no difference between SB and SP were observed. The XLA diet reduced feed intake and daily gain compared with PC and NC, where SP, SB, and XLA had a poorer feed conversion compared with PC. Conclusively, the SP and SB low-protein diets did not reduce diarrhoea or growth performance, whereas the XLA diet decreased both diarrhoea and performance.

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