scholarly journals Fully Ripe “Ataulfo” Mango (Mangifera indica L) Peel, Pulp and Isolated Fiber: Sources of Bioactive Components Against Metabolic Syndrome

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 611-611
Author(s):  
Rosabel Velez de la Rocha ◽  
Kirenia Baldenebro Ojeda ◽  
Adriana Sañudo Barajas ◽  
Marcela Vergara-Jiménez
Keyword(s):  
Metabolic Syndrome ◽  
Vitamin C ◽  
Dietary Fiber ◽  
Bioactive Components ◽  
Free Sugars ◽  
The Metabolic Syndrome ◽  
Mango Peel ◽  
Neutral Sugars ◽  
Mango Pulp ◽  
Proximal Analysis

Abstract Objectives To evaluate the proximal composition of pulp, peel and isolated fiber of fully ripe “Ataulfo” mango, as a potential sources of bioactive components against factors associated with the metabolic syndrome. Methods Fully ripe Ataulfo mangos were harvest from Sinaloa, Mexico. Pulp and peels were separated, lyophilized and grounded. Lyophilized peels were whashed using a 80% ethanol and acetone solution to obtain isolated fiber. Proximal analysis was performed using the official AOAC methodologies for protein, fat, ash and soluble and insoluble dietary fiber. Glucose, fructose and saccharose were analyzed using enzymatic method. Folin-Ciocaltieu assay was used to evaluate total phenolics, total flavonoids were measured by spectrophotometry. Vitamin C and b-carotene were determinated by UV-Vis chromatography. Neutral sugars were measured by alditol acetates method. Data analysis was done using SAS statistic software. Results Great differences in the bioactive composition between pulp, peel and isolated fiber were observed. Mango pulp had 71% and 10.1%, while isolated fiber 0.9 and 81% of free sugars and dietary fiber respectively. Mango peel exhibed a balanced free sugar (38%) and fiber quantities (41%), and also the highest amounts of phenolics and total flavonoids, b-carotene and vitamin C. Soluble and insoluble fiber ratio was around 1 in pulp, peel and isolated fiber, which is considered as good quality dietary fiber. Glucose, arabinose and galactose were major neutral sugars, and revealed probable structure type arabinogalactan, b-glucan or arabinan. Mango peel had the most abundant content of dietary fiber, total phenolic and flavonoids, vitamin C and β-carotene, and the lowest amount of free sugars compared to mango pulp. According to the reported literature, our products could have bioactive components against the metabolic syndrome related factors, and even better, mango peel had less free sugars than mango pulp. Conclusions Mango peel seems to have the major presence of bioactive compounds compared to mango pulp, After this proximal analysis, mango peel can not longer be considered as a waste product. More studies need be done in order to probe the effectiveness of the bioactive components found in mango peel associated with the control of the most important risk factors related to the metabolic syndrome. Funding Sources University of Sinaloa, CIAD.

Generalized impairment of vasodilator reactivity during hyperinsulinemia in patients with obesity-related metabolic syndrome

2010 ◽  
Vol 299 (6) ◽  
pp. E947-E952 ◽  
Author(s):  
Francesca Schinzari ◽  
Manfredi Tesauro ◽  
Valentina Rovella ◽  
Angelica Galli ◽  
Nadia Mores ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Vitamin C ◽  
Vascular Reactivity ◽  
Vascular Complications ◽  
Glucose Disposal ◽  
Vascular Abnormalities ◽  
Insulin Resistant ◽  
The Metabolic Syndrome ◽  
Before And After

Defective insulin-dependent vasodilation might contribute importantly to metabolic and vascular abnormalities of the metabolic syndrome (MetS). However, despite extensive investigation, the precise mechanisms involved in insulin's vasoactive effects have not been fully elucidated. Therefore, this study sought to better characterize insulin's physiological actions on vascular reactivity and their potential derangement in the MetS. Forearm blood flow responses to graded doses of acetylcholine, sodium nitroprusside, and verapamil were assessed by strain-gauge plethysmography in patients with obesity-related MetS ( n = 20) and in matched controls ( n = 18) before and after intra-arterial infusion of insulin (0.2 mU·kg−1·min−1). Possible involvement of increased oxidative stress in the impaired insulin-stimulated vasodilator responsiveness of patients with MetS ( n = 12) was also investigated using vitamin C (25 mg/min). In control subjects, significant potentiation of the vasodilator responses to acetylcholine, nitroprusside, and verapamil was observed after insulin infusion (all P < 0.05). However, no significant change in vasodilator reactivity to either of these drugs was observed following hyperinsulinemia in patients with MetS (all P > 0.05). Interestingly, administration of vitamin C to patients with MetS during hyperinsulinemia significantly enhanced the vasodilator responsiveness to acetylcholine, nitroprusside, and verapamil (all P < 0.05 vs. hyperinsulinemia alone). In conclusion, insulin exerts a generalized facilitatory action on vasodilator reactivity, and this effect is impaired in patients with MetS likely because of increased oxidative stress. Given the importance of vasodilator reactivity in affecting glucose disposal and vascular homeostasis, this defect may then contribute to the development of metabolic and vascular complications in insulin-resistant states.

Nutritional strategies in the prevention and treatment of metabolic syndrome

2007 ◽  
Vol 32 (1) ◽  
pp. 46-60 ◽  
Author(s):  
Sabrina E. Feldeisen ◽  
Katherine L. Tucker
Keyword(s):  
Metabolic Syndrome ◽  
Environmental Factors ◽  
Dietary Fiber ◽  
Atherosclerotic Cardiovascular Disease ◽  
Dietary Recommendations ◽  
Low Fat ◽  
The Metabolic Syndrome ◽  
Prevention And Treatment ◽  
Total Fat

The metabolic syndrome (MetS) is a clustering of metabolic abnormalities that increase the risk of developing atherosclerotic cardiovascular disease and type 2 diabetes. The exact etiology remains unclear, but it is known to be a complex interaction between genetic, metabolic, and environmental factors. Among environmental factors, dietary habits are of central importance in the prevention and treatment of this condition. However, there is currently no firm consensus on the most appropriate dietary recommendations. General recommendations include decreasing obesity, increasing physical activity, and consuming an anti-atherogenic diet, and have traditionally focused on low total fat intake. A major problem with the focus on low fat is that high-carbohydrate diets can contribute to increasing triglyceride and decreasing high-density lipoprotein (HDL) concentrations. Low-carbohydrate diets have been popular in recent years. However, such diets are typically higher in saturated fat and lower in fruits, vegetables, and whole grains than national dietary recommendations. More recently the quality of carbohydrate has been studied in relation to MetS, including a focus on dietary fiber and glycemic index. Similarly, there has been a move from limiting total fat to a focus on the quality of the fat, with evidence of beneficial effects of replacing some carbohydrate with monounsaturated fat. Other nutrients examined for possible importance include calcium, vitamin D, and magnesium. Together, the evidence suggests that the components of diet currently recommended as “healthy” are likely also protective against MetS, including low saturated and trans fat (rather than low total fat) and balanced carbohydrate intake rich in dietary fiber, as well as high fruit and vegetable intake (rather than low total carbohydrate); and the inclusion of low-fat dairy foods. Accelerating research on gene–diet interactions is likely to contribute interesting information that may lead to further individualized dietary guidance in the future.

scholarly journals Rho-kinase inhibition improves vasodilator responsiveness during hyperinsulinemia in the metabolic syndrome

2012 ◽  
Vol 303 (6) ◽  
pp. E806-E811 ◽  
Author(s):  
Francesca Schinzari ◽  
Manfredi Tesauro ◽  
Valentina Rovella ◽  
Nicola Di Daniele ◽  
Paolo Gentileschi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Vitamin C ◽  
Insulin Infusion ◽  
Rho Kinase ◽  
Facilitatory Effect ◽  
The Metabolic Syndrome ◽  
Before And After ◽  
Forearm Circulation ◽  
Rock Inhibition

In patients with the metabolic syndrome (MetS), the facilitatory effect of insulin on forearm vasodilator responsiveness to different stimuli is impaired. Whether the RhoA/Rho kinase (ROCK) pathway is involved in this abnormality is unknown. We tested the hypotheses that, in MetS patients, ROCK inhibition with fasudil restores insulin-stimulated vasodilator reactivity and that oxidative stress plays a role in this mechanism. Endothelium-dependent and -independent forearm blood flow responses to acetylcholine (ACh) and sodium nitroprusside (SNP), respectively, were assessed in MetS patients ( n = 8) and healthy controls ( n = 5) before and after the addition of fasudil (200 μg/min) to an intra-arterial infusion of insulin (0.1 mU/kg/min). In MetS patients ( n = 5), fasudil was also infused without hyperinsulinemia. The possible involvement of oxidative stress in the effect of fasudil during hyperinsulinemia was investigated in MetS patients ( n = 5) by infusing vitamin C (25 mg/min). In MetS patients, compared with saline, fasudil enhanced endothelium-dependent and -independent vasodilator responses during insulin infusion ( P < 0.001 and P = 0.008, respectively), but not in the absence of hyperinsulinemia ( P = 0.25 and P = 0.13, respectively). By contrast, fasudil did not affect vasoreactivity to ACh and SNP during hyperinsulinemia in controls ( P = 0.11 and P = 0.56, respectively). In MetS patients, fasudil added to insulin and vitamin C did not further enhance vasodilation to ACh and SNP ( P = 0.15 and P = 0.43, respectively). In the forearm circulation of patients with the MetS, ROCK inhibition by fasudil improves endothelium-dependent and -independent vasodilator responsiveness during hyperinsulinemia; increased oxidative stress seems to be involved in the pathophysiology of this phenomenon.

Dietary Fiber and Nutrient Density Are Inversely Associated with the Metabolic Syndrome in US Adolescents

2011 ◽  
Vol 111 (11) ◽  
pp. 1688-1695 ◽  
Author(s):  
Joseph J. Carlson ◽  
Joey C. Eisenmann ◽  
Gregory J. Norman ◽  
Karen A. Ortiz ◽  
Paul C. Young
Keyword(s):  
Metabolic Syndrome ◽  
Dietary Fiber ◽  
The Metabolic Syndrome ◽  
Nutrient Density

scholarly journals Testosterone and Its Bioactive Components Are Associated with Libido and the Metabolic Syndrome in Men

2017 ◽  
Vol 07 (02) ◽  
pp. 105-119 ◽  
Author(s):  
H. Alidu ◽  
N. Amidu ◽  
W. K. B. A. Owiredu ◽  
C. K. Gyasi-Sarpong ◽  
A. T. Bawah ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Bioactive Components ◽  
The Metabolic Syndrome

scholarly journals Bioactive components, antioxidative properties and inhibition of Fe2+-induced lipid peroxidation of mango peel as affected by the storage of mango fruit

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Adetuyi O. Foluso ◽  
Akinlerye Makinde ◽  
Ifedayo Adeyemi ◽  
Victoria Timothy
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin C ◽  
Room Temperature ◽  
Total Phenolics ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Total Phenolic ◽  
Bioactive Components ◽  
Mango Fruit ◽  
Mango Peel

This study sought to evaluate the bioactive components (total phenolics, vitamin C and flavonoid), antioxidant properties (FRAP, and hydroxyl, DPPH and ABTS radical scavenging abilities) and inhibition of Fe2+-induced lipid peroxidation of the peel of mango fruit stored at refrigeration temperature and room temperature. The peel of mango fruit stored at room temperature had significantly (P ≤ 0.05) higher contents of total phenolic (13.61 mg GAE/g), vitamin C (12.98 mg AAE/g), total flavonoid (4.49 mg QE/g) and non-flavonoid (9.12 mg Qe/g) than the peel of freshly harvested mango fruit and the peel of mango fruit stored at refrigeration temperature. In consonance with the bioactive components, the peel of mango fruit stored at room temperature had a higher FRAP, and hydroxyl, DPPH and ABTS radical scavenging abilities than the others. The peel of mango fruit stored at room temperature showed stronger inhibition of Fe2+ induced lipid peroxidation by exhibiting the least IC50 (1.44 mg/ml in brain), (1.43 mg/ml in pancreas) and (1.88 mg/ml in kidney). Thus freshly harvested, matured, edible and just ripe mango fruit (Sheri Mango) could be stored at room temperature and be consumed with the peel.

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